Reassessing the role of high dose cytarabine and mitoxantrone in relapsed/refractory acute myeloid leukemia.
FLT3-ITD
acute myeloid leukemia
next-generation sequencing
Journal
Oncotarget
ISSN: 1949-2553
Titre abrégé: Oncotarget
Pays: United States
ID NLM: 101532965
Informations de publication
Date de publication:
09 Jun 2020
09 Jun 2020
Historique:
received:
30
01
2020
accepted:
14
05
2020
entrez:
25
6
2020
pubmed:
25
6
2020
medline:
25
6
2020
Statut:
epublish
Résumé
A substantial segment of patients with acute myeloid leukemia (AML) will relapse following an initial response to induction therapy or will prove to be primary refractory. High-dose cytarabine and mitoxantrone (HiDAC/MITO) is an established salvage therapy for these patients. We studied all adult patients with relapsed/refractory (R/R) AML who were treated with HiDAC/MITO in our center between the years 2008-2017. To determine whether responding patients harbored a unique molecular signature, we performed targeted next-generation sequencing (NGS) on a subset of patients. The study cohort consisted of 172 patients with a median age of 54 years (range 18-77). The composite complete remission rate was 58%; 11 patients (6%) died during salvage therapy. Median survival was 11.4 months with a 1-year survival rate of 48%. In multivariate analysis favorable risk cytogenetics [Odds ratio (OR)=0.34, confidence interval (CI) 95%, 0.17-0.68;
Identifiants
pubmed: 32577167
doi: 10.18632/oncotarget.27618
pii: 27618
pmc: PMC7289527
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2233-2245Informations de copyright
Copyright: © 2020 Canaani et al.
Déclaration de conflit d'intérêts
CONFLICTS OF INTEREST None.
Références
Cancer Discov. 2019 Aug;9(8):1050-1063
pubmed: 31088841
Leukemia. 2017 Jun;31(6):1306-1313
pubmed: 28138160
Am J Hematol. 2013 Jul;88(7):601-5
pubmed: 23619977
Leukemia. 2017 May;31(5):1217-1220
pubmed: 28096533
Nature. 2018 Oct;562(7728):526-531
pubmed: 30333627
Blood. 2019 Feb 14;133(7):676-687
pubmed: 30510081
Br J Haematol. 2016 Sep;174(5):700-10
pubmed: 27118319
Blood. 2017 Jan 26;129(4):424-447
pubmed: 27895058
Leukemia. 1993 Apr;7(4):549-52
pubmed: 8464233
Nature. 2018 Jul;559(7712):125-129
pubmed: 29950729
Blood. 2010 Dec 23;116(26):5818-23; quiz 6153
pubmed: 20923968
Nature. 2012 Jan 11;481(7382):506-10
pubmed: 22237025
Blood. 2000 Sep 15;96(6):2055-61
pubmed: 10979947
Nat Commun. 2019 Jan 16;10(1):244
pubmed: 30651561
Leuk Lymphoma. 1993 Mar;9(4-5):343-50
pubmed: 8394169
N Engl J Med. 2018 Mar 29;378(13):1189-1199
pubmed: 29601269
J Clin Oncol. 2013 Apr 1;31(10):1293-301
pubmed: 23439754
N Engl J Med. 2007 Jan 25;356(4):348-59
pubmed: 17251531
Leukemia. 2011 Jun;25(6):939-44
pubmed: 21331073
Leuk Res. 1999 Sep;23(9):787-94
pubmed: 10475617
Leukemia. 1994 Jan;8(1):6-10
pubmed: 8289499
Blood. 2009 Apr 16;113(16):3666-72
pubmed: 19020306
J Clin Oncol. 1985 Jul;3(7):992-7
pubmed: 3894588
Lancet Oncol. 2015 Sep;16(9):1025-1036
pubmed: 26234174
Haematologica. 2016 Jul;101(7):839-45
pubmed: 27036160
Blood. 2009 Nov 5;114(19):4027-33
pubmed: 19710500
Leukemia. 2015 Feb;29(2):312-20
pubmed: 25113226
Am J Hematol. 2018 Jun 15;:
pubmed: 29905379
J Clin Oncol. 2012 Jul 10;30(20):2492-9
pubmed: 22585697
Leukemia. 2007 Jan;21(1):66-71
pubmed: 17051246
Genes Chromosomes Cancer. 2019 Dec;58(12):875-888
pubmed: 31393631
Blood. 2015 May 21;125(21):3359-60
pubmed: 25999448
N Engl J Med. 2019 Oct 31;381(18):1728-1740
pubmed: 31665578
J Clin Oncol. 2014 Jun 20;32(18):1919-26
pubmed: 24841975
J Clin Oncol. 2005 Mar 20;23(9):1969-78
pubmed: 15632409
Ann Hematol. 2018 Jul;97(7):1115-1153
pubmed: 29680875
Leuk Res. 1999 Aug;23(8):695-700
pubmed: 10456666
Haematologica. 2010 Nov;95(11):1857-64
pubmed: 20634493
N Engl J Med. 2012 Mar 22;366(12):1079-89
pubmed: 22417203
Blood. 2015 Jul 16;126(3):319-27
pubmed: 25852056
Leukemia. 1993 Oct;7(10):1496-9
pubmed: 8412309
J Intern Med. 2019 Apr;285(4):407-418
pubmed: 30372796
N Engl J Med. 2013 May 30;368(22):2059-74
pubmed: 23634996
Haematologica. 2016 Nov;101(11):1351-1358
pubmed: 27540133
Clin Cancer Res. 2018 May 1;24(9):2060-2073
pubmed: 29437791
N Engl J Med. 2016 Jun 9;374(23):2209-2221
pubmed: 27276561
J Clin Oncol. 2003 Dec 15;21(24):4642-9
pubmed: 14673054
Blood. 2016 Jan 7;127(1):53-61
pubmed: 26660429
Ann Hematol. 1999 Sep;78(9):418-25
pubmed: 10525830
Blood. 2010 Jul 22;116(3):354-65
pubmed: 20385793
Br J Haematol. 2001 Jan;112(1):127-37
pubmed: 11167793
Leukemia. 1994 Nov;8(11):1847-53
pubmed: 7967730
Br J Haematol. 2011 Oct;155(2):182-9
pubmed: 21848522
Br J Haematol. 2011 Nov;155(4):413-9
pubmed: 21910721
N Engl J Med. 2018 Jun 21;378(25):2386-2398
pubmed: 29860938