Laboratory and clinical management of leukocytospermia and hematospermia: a review.
cryopreservation
hematospermia
leukocytospermia
management
sperm separation
testicular biopsy
Journal
Therapeutic advances in reproductive health
ISSN: 2633-4941
Titre abrégé: Ther Adv Reprod Health
Pays: England
ID NLM: 101765379
Informations de publication
Date de publication:
Historique:
received:
30
01
2020
accepted:
08
04
2020
entrez:
25
6
2020
pubmed:
25
6
2020
medline:
25
6
2020
Statut:
epublish
Résumé
Leukocytospermia and hematospermia are defined as the presence of abnormally high white blood cell and red blood cell concentration in the semen, respectively. Numerous etiologies and various implications on fertility have been identified. In a small proportion of men, the presence of white blood cells or red blood cells can adversely affect sperm quality by the production of reactive oxygen species. Several methods have been used to assess the presence of white blood cells and red blood cells in samples, such as identification of round cells, immunohistochemical staining using monoclonal antibodies, the Endtz test, the peroxidase test, and flow cytometry or microscopy. In addition, techniques have been identified to separate sperm samples from white blood cells and red blood cells for cryopreservation to improve outcomes in assisted reproductive technology. In this review, laboratory and clinical management of leukocytospermia and hematospermia are discussed. Currently available diagnostic methods and treatment options are outlined, and available optimal cryopreservation techniques for samples with white blood cells or red blood cells are summarized.
Identifiants
pubmed: 32577619
doi: 10.1177/2633494120922511
pii: 10.1177_2633494120922511
pmc: PMC7290265
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
2633494120922511Informations de copyright
© The Author(s), 2020.
Déclaration de conflit d'intérêts
Conflict of interest statement: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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