Differential expression of Bax-Bcl-2 and PARP-1 confirms apoptosis of EAC cells in Swiss albino mice by Morus laevigata.
Morus
Bax-Bcl-2
DNA fragmentation
anticancer
antioxidant
apoptosis
Journal
Journal of food biochemistry
ISSN: 1745-4514
Titre abrégé: J Food Biochem
Pays: United States
ID NLM: 7706045
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
24
03
2020
revised:
27
05
2020
accepted:
28
05
2020
pubmed:
25
6
2020
medline:
22
6
2021
entrez:
25
6
2020
Statut:
ppublish
Résumé
A safer natural alternative to treat neoplastic cells by inducing apoptosis is a prime requisite. Therefore, the current study was to evaluate the antiproliferative activity of Morus laevigata, a wild-type Mulberry species. Antioxidant and cytotoxic activity of aqueous extracts of M. laevigata leaf (MLL) and M. laevigata bark (MLB) were evaluated. The in vivo cell growth inhibition was assessed on Ehrlich's ascites carcinoma (EAC) bearing mice model. Fluorescent microscopy and expression of PARP-1, Bax, and Bcl-2 through qPCR were performed to evaluate apoptosis. MLL and MLB extracts show promising antioxidant property with an IC
Substances chimiques
Bax protein, mouse
0
Plant Extracts
0
Poly(ADP-ribose) Polymerase Inhibitors
0
Proto-Oncogene Proteins c-bcl-2
0
bcl-2-Associated X Protein
0
Bcl2 protein, mouse
114100-40-2
Parp1 protein, mouse
EC 2.4.2.30
Poly (ADP-Ribose) Polymerase-1
EC 2.4.2.30
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13342Informations de copyright
© 2020 Wiley Periodicals LLC.
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