Exoenzyme Y induces extracellular active caspase-7 accumulation independent from apoptosis: modulation of transmissible cytotoxicity.
Animals
Apoptosis
/ physiology
Bacterial Proteins
/ metabolism
Caspase 3
/ metabolism
Caspase 7
/ metabolism
Cell Death
/ physiology
Cells, Cultured
Endothelial Cells
/ metabolism
Glucosyltransferases
/ metabolism
Lung
/ metabolism
Male
Microvessels
/ metabolism
Pseudomonas Infections
/ metabolism
Pseudomonas aeruginosa
/ pathogenicity
Rats
Rats, Sprague-Dawley
tau
Pseudomonas aeruginosa
amyloid
caspase-3
transmissible cytotoxicity
Journal
American journal of physiology. Lung cellular and molecular physiology
ISSN: 1522-1504
Titre abrégé: Am J Physiol Lung Cell Mol Physiol
Pays: United States
ID NLM: 100901229
Informations de publication
Date de publication:
01 08 2020
01 08 2020
Historique:
pubmed:
25
6
2020
medline:
21
11
2020
entrez:
25
6
2020
Statut:
ppublish
Résumé
Caspase-3 and -7 are executioner caspases whose enzymatic activity is necessary to complete apoptotic cell death. Here, we questioned whether endothelial cell infection leads to caspase-3/7-mediated cell death. Pulmonary microvascular endothelial cells (PMVECs) were infected with
Identifiants
pubmed: 32579398
doi: 10.1152/ajplung.00508.2019
pmc: PMC7473935
doi:
Substances chimiques
Bacterial Proteins
0
ExoY protein, bacteria
EC 2.4.-
Glucosyltransferases
EC 2.4.1.-
Caspase 3
EC 3.4.22.-
Caspase 7
EC 3.4.22.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
L380-L390Subventions
Organisme : NIAID NIH HHS
ID : R01 AI104922
Pays : United States
Organisme : HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI)
ID : HL60024
Pays : International
Organisme : NHLBI NIH HHS
ID : R01 HL148069
Pays : United States
Organisme : HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI)
ID : HL66299
Pays : International
Organisme : NHLBI NIH HHS
ID : R37 HL060024
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL060024
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL066299
Pays : United States
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