Interferon Alpha Induces Multiple Cellular Proteins That Coordinately Suppress Hepadnaviral Covalently Closed Circular DNA Transcription.
Animals
Antiviral Agents
/ metabolism
Cell Line
Chickens
Chromosomal Proteins, Non-Histone
/ chemistry
DNA, Circular
/ metabolism
DNA, Viral
/ genetics
Epigenesis, Genetic
Hepadnaviridae
/ drug effects
Hepadnaviridae Infections
/ virology
Hepatitis B Virus, Duck
/ drug effects
Hepatitis B virus
Hepatitis B, Chronic
/ virology
Hepatocytes
/ virology
Histone Code
Histones
/ metabolism
Humans
Interferon-alpha
/ genetics
Promyelocytic Leukemia Protein
/ metabolism
Protein Processing, Post-Translational
RNA, Viral
STAT1 Transcription Factor
/ metabolism
Transcription, Genetic
Virus Replication
cccDNA
hepatitis B virus
interferons
transcription
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
17 08 2020
17 08 2020
Historique:
received:
12
03
2020
accepted:
15
06
2020
pubmed:
26
6
2020
medline:
1
12
2020
entrez:
26
6
2020
Statut:
epublish
Résumé
Covalently closed circular DNA (cccDNA) of hepadnaviruses exists as an episomal minichromosome in the nucleus of an infected hepatocyte and serves as the template for the transcription of viral mRNAs. It had been demonstrated by others and us that interferon alpha (IFN-α) treatment of hepatocytes induced a prolonged suppression of human and duck hepatitis B virus cccDNA transcription, which is associated with the reduction of cccDNA-associated histone modifications specifying active transcription (H3K9
Identifiants
pubmed: 32581092
pii: JVI.00442-20
doi: 10.1128/JVI.00442-20
pmc: PMC7431811
pii:
doi:
Substances chimiques
Antiviral Agents
0
Chromosomal Proteins, Non-Histone
0
DNA, Circular
0
DNA, Viral
0
Histones
0
Interferon-alpha
0
Promyelocytic Leukemia Protein
0
RNA, Viral
0
SMCHD1 protein, human
0
STAT1 Transcription Factor
0
PML protein, human
143220-95-5
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI113267
Pays : United States
Informations de copyright
Copyright © 2020 American Society for Microbiology.
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