Shelterin Complex at Telomeres: Implications in Ageing.

Aging / genetics DNA Replication Humans Oxidative Stress Telomerase / metabolism Telomere / metabolism Telomere-Binding Proteins / genetics
ageing sheltering complex telomeres

Journal

Clinical interventions in aging
ISSN: 1178-1998
Titre abrégé: Clin Interv Aging
Pays: New Zealand
ID NLM: 101273480

Informations de publication

Date de publication:
2020
Historique:
received: 01 04 2020
accepted: 18 05 2020
entrez: 26 6 2020
pubmed: 26 6 2020
medline: 18 11 2020
Statut: epublish

Résumé

Different factors influence the development‎ and control of ageing. It is well known that progressive telomere shorting is one of the molecular mechanisms underlying ageing. The shelterin complex consists of six telomere-specific proteins which are involved in the protection of chromosome ends. More particularly, this vital complex protects the telomeres from degradation, prevents from activation of unwanted repair systems, regulates the activity of telomerase, and has a crucial role in cellular senescent and ageing-related pathologies. This review explores the organization and function of telomeric DNA along with the mechanism of telomeres during ageing, followed by a discussion of the critical role of shelterin components and their changes during ageing.

Identifiants

DOI: 10.2147/CIA.S256425 PMID: 32581523 PMC: PMC7276337
pubmed: 32581523
doi: 10.2147/CIA.S256425
pii: 256425
pmc: PMC7276337
doi:

Substances chimiques

Telomere-Binding Proteins 0
Telomerase EC 2.7.7.49

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

827-839

Informations de copyright

© 2020 Mir et al.

Déclaration de conflit d'intérêts

The authors report that there are no conflicts of interest in this work.

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Auteurs

Seyed Mostafa Mir (SM)

Trauma Research Center, AJA University of Medical Sciences, Tehran, Iran.
Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.

Sadra Samavarchi Tehrani (S)

Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Student Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
ORCID: 0000-0002-1043-2443

Golnaz Goodarzi (G)

Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Student Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Zahra Jamalpoor (Z)

Trauma Research Center, AJA University of Medical Sciences, Tehran, Iran.

Jahanbakhsh Asadi (J)

Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran.

Nafiseh Khelghati (N)

Department of Clinical Biochemistry, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.

Durdi Qujeq (D)

Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
ORCID: 0000-0003-1344-9344

Mahmood Maniati (M)

School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Shelterin Complex at Telomeres: Implications in Ageing.
questionsmedicales.fr › Phénomènes génétiques › Réplication de l'ADN › Shelterin Complex at Telomeres: Implications in Ageing.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Shelterin Complex at Telomeres: Implications in Ageing.
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Shelterin Complex at Telomeres: Implications in Ageing.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Ribonucléoprotéines › Telomerase › Shelterin Complex at Telomeres: Implications in Ageing.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Télomère › Shelterin Complex at Telomeres: Implications in Ageing.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéines télomériques › Shelterin Complex at Telomeres: Implications in Ageing.