LRRK2-Related Parkinson's Disease Due to Altered Endolysosomal Biology With Variable Lewy Body Pathology: A Hypothesis.
LRRK2
Parkinson’s disease
Rab protein
glucocerebrosidase
lysosomal storage disorder
lysosome
phosphorylation
α-synuclein
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2020
2020
Historique:
received:
30
03
2020
accepted:
06
05
2020
entrez:
26
6
2020
pubmed:
26
6
2020
medline:
26
6
2020
Statut:
epublish
Résumé
Mutations in the gene encoding for leucine-rich repeat kinase 2 (LRRK2) are associated with both familial and sporadic Parkinson's disease (PD). LRRK2 encodes a large protein comprised of a GTPase and a kinase domain. All pathogenic variants converge on enhancing LRRK2 kinase substrate phosphorylation, and distinct LRRK2 kinase inhibitors are currently in various stages of clinical trials. Although the precise pathophysiological functions of LRRK2 remain largely unknown, PD-associated mutants have been shown to alter various intracellular vesicular trafficking pathways, especially those related to endolysosomal protein degradation events. In addition, biochemical studies have identified a subset of Rab proteins, small GTPases required for all vesicular trafficking steps, as substrate proteins for the LRRK2 kinase activity
Identifiants
pubmed: 32581693
doi: 10.3389/fnins.2020.00556
pmc: PMC7287096
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
556Informations de copyright
Copyright © 2020 Rivero-Ríos, Romo-Lozano, Fasiczka, Naaldijk and Hilfiker.
Références
Mov Disord. 2014 Apr;29(4):454-62
pubmed: 24619848
Philos Trans R Soc Lond B Biol Sci. 2003 May 29;358(1433):885-91
pubmed: 12803922
Ann Clin Transl Neurol. 2019 May 09;6(6):1024-1032
pubmed: 31211166
Hum Mol Genet. 2019 Aug 15;28(16):2696-2710
pubmed: 31039583
Cold Spring Harb Perspect Biol. 2014 Oct 23;6(11):a022616
pubmed: 25341920
Mol Neurodegener. 2012 Aug 24;7:42
pubmed: 22920859
NPJ Parkinsons Dis. 2017 Apr 10;3:14
pubmed: 28649614
Science. 2004 Aug 27;305(5688):1292-5
pubmed: 15333840
J Lipid Res. 2015 May;56(5):1006-13
pubmed: 25795792
J Cell Sci. 2012 Nov 1;125(Pt 21):5026-39
pubmed: 22854040
Brain. 2005 Dec;128(Pt 12):2760-2
pubmed: 16311269
Autophagy. 2016 Nov;12(11):1984-1999
pubmed: 27487474
J Parkinsons Dis. 2015;5(2):209-15
pubmed: 25624421
Cytoskeleton (Hoboken). 2011 Oct;68(10):527-39
pubmed: 21850707
J Cell Sci. 2015 Apr 1;128(7):1386-99
pubmed: 25673874
Neuron. 2018 Jan 3;97(1):92-107.e10
pubmed: 29290548
J Neurochem. 2009 Oct;111(1):192-203
pubmed: 19686384
J Lipid Res. 2013 Jun;54(6):1691-7
pubmed: 23564732
Redox Biol. 2014 Jun 12;2:749-54
pubmed: 25009776
J Biol Chem. 2009 May 1;284(18):12110-24
pubmed: 19265192
Mov Disord. 2020 May;35(5):760-773
pubmed: 32034799
Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9115-E9124
pubmed: 30209220
Am J Pathol. 2009 Aug;175(2):736-47
pubmed: 19628769
Biochem Soc Trans. 2017 Feb 8;45(1):155-162
pubmed: 28202669
Biochem Soc Trans. 2017 Feb 8;45(1):163-172
pubmed: 28202670
Mov Disord. 2017 Nov;32(11):1504-1523
pubmed: 29124790
Lancet. 2005 Jan 29-Feb 4;365(9457):415-6
pubmed: 15680457
Neurology. 2010 Nov 16;75(20):1766-72
pubmed: 20962290
Mol Biol Cell. 2004 Oct;15(10):4500-11
pubmed: 15292453
J Cell Biol. 2010 Oct 18;191(2):367-81
pubmed: 20937701
Biochem Biophys Res Commun. 2005 Sep 16;335(1):154-61
pubmed: 16055087
Hum Mol Genet. 2018 Sep 15;27(18):3257-3271
pubmed: 29917075
Am J Hum Genet. 2003 Mar;72(3):722-7
pubmed: 12545426
Biosci Rep. 2011 Jun;31(3):159-68
pubmed: 21250943
Toxicology. 2014 Oct 3;324:1-9
pubmed: 25017139
Front Neurosci. 2018 Feb 19;12:80
pubmed: 29515354
J Neurosci. 2012 Nov 14;32(46):16503-9
pubmed: 23152632
Mol Biol Cell. 2007 Jan;18(1):47-56
pubmed: 17050734
Curr Biol. 2010 Sep 28;20(18):1654-9
pubmed: 20797862
Eur J Hum Genet. 2006 Mar;14(3):322-31
pubmed: 16333314
Cell Rep. 2017 Feb 21;18(8):1831-1839
pubmed: 28228250
N Engl J Med. 2006 Jan 26;354(4):422-3
pubmed: 16436781
Neuron. 2013 Feb 6;77(3):425-39
pubmed: 23395371
Hum Mol Genet. 2007 Sep 1;16(17):2031-9
pubmed: 17584768
J Pathol. 2014 Apr;232(5):509-21
pubmed: 24415155
Nat Neurosci. 2006 Oct;9(10):1231-3
pubmed: 16980962
Curr Opin Cell Biol. 2020 Apr;63:102-113
pubmed: 32036294
Expert Rev Neurother. 2012 Jun;12(6):673-86
pubmed: 22650170
Neuron. 2006 Nov 22;52(4):587-93
pubmed: 17114044
Neurology. 2013 Apr 23;80(17):1606-10
pubmed: 23535491
J Neurochem. 2020 Feb;152(3):273-283
pubmed: 31693760
Parkinsonism Relat Disord. 2020 May;74:76-77
pubmed: 31734038
Hum Mol Genet. 2009 Nov 1;18(21):4022-34
pubmed: 19640926
J Neurosci. 2004 Jul 28;24(30):6715-23
pubmed: 15282274
Neurobiol Aging. 2003 Mar-Apr;24(2):197-211
pubmed: 12498954
Elife. 2017 Nov 10;6:
pubmed: 29125462
Mol Neurodegener. 2018 Jan 23;13(1):3
pubmed: 29357897
Elife. 2013 Dec 10;2:e01064
pubmed: 24327558
Mol Neurodegener. 2019 Aug 29;14(1):36
pubmed: 31464647
Elife. 2016 Jan 29;5:
pubmed: 26824392
Hum Mol Genet. 2014 Dec 20;23(25):6779-96
pubmed: 25080504
J Cell Sci. 2006 Dec 1;119(Pt 23):4866-77
pubmed: 17105768
Mol Neurodegener. 2019 Jun 11;14(1):23
pubmed: 31186026
J Lipid Res. 2010 Jul;51(7):1643-75
pubmed: 20211931
Front Neurosci. 2016 Sep 05;10:408
pubmed: 27656123
J Neurochem. 2008 May;105(3):1048-56
pubmed: 18182054
Neurobiol Dis. 2018 Mar;111:26-35
pubmed: 29246723
J Mol Cell Biol. 2011 Aug;3(4):239-49
pubmed: 21733982
Acta Neuropathol Commun. 2019 Nov 16;7(1):183
pubmed: 31733655
Science. 2000 Nov 3;290(5493):985-9
pubmed: 11062131
J Cell Sci. 2015 Jan 15;128(2):232-8
pubmed: 25416817
Neurology. 2007 Apr 3;68(14):1141-3
pubmed: 17215492
Mol Neurodegener. 2015 Jul 11;10:26
pubmed: 26159606
Dev Cell. 2011 Jan 18;20(1):131-9
pubmed: 21238931
Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15573-8
pubmed: 25316793
Biochem Biophys Res Commun. 2009 Jan 16;378(3):473-7
pubmed: 19027715
J Cell Biol. 2019 Dec 2;218(12):4157-4170
pubmed: 31624137
Nat Commun. 2019 Dec 5;10(1):5570
pubmed: 31804465
Front Neurol. 2018 Dec 11;9:1021
pubmed: 30619023
Lancet. 2015 Aug 29;386(9996):896-912
pubmed: 25904081
Neurobiol Dis. 2018 Jan;109(Pt B):209-218
pubmed: 28751258
Acta Neuropathol Commun. 2014 Feb 14;2:20
pubmed: 24529306
Hum Mol Genet. 2012 Mar 15;21(6):1350-63
pubmed: 22171073
J Clin Invest. 2008 Feb;118(2):777-88
pubmed: 18172548
Alzheimers Res Ther. 2014 Oct 27;6(5):73
pubmed: 25580161
Nat Med. 2008 May;14(5):501-3
pubmed: 18391963
Parkinsonism Relat Disord. 2020 May;74:78-79
pubmed: 31727562
Science. 2010 Sep 24;329(5999):1663-7
pubmed: 20798282
Mov Disord. 2011 Aug 1;26(9):1593-604
pubmed: 21618611
J Biol Chem. 2019 Mar 29;294(13):4738-4758
pubmed: 30709905
Biochem Biophys Res Commun. 2007 Jun 22;358(1):111-6
pubmed: 17482562
J Cell Sci. 2004 Sep 15;117(Pt 20):4837-48
pubmed: 15340014
Brain. 2015 Jun;138(Pt 6):1642-57
pubmed: 25732184
Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2626-31
pubmed: 24510904
Nature. 2010 Jun 17;465(7300):942-6
pubmed: 20526321
Hum Mol Genet. 2006 Jan 15;15(2):223-32
pubmed: 16321986
Hum Mol Genet. 2007 Jun 1;16(11):1319-26
pubmed: 17409193
J Neurosci. 2000 May 1;20(9):3214-20
pubmed: 10777786
J Clin Invest. 2002 Jun;109(12):1541-50
pubmed: 12070301
Cell Stem Cell. 2016 Dec 1;19(6):709-724
pubmed: 27618216
FEBS J. 2009 Jan;276(2):466-78
pubmed: 19076219
Front Hum Neurosci. 2019 Sep 04;13:306
pubmed: 31551736
Nat Neurosci. 2019 Jul;22(7):1099-1109
pubmed: 31235907
Trends Endocrinol Metab. 2010 Mar;21(3):142-50
pubmed: 19857975
J Neurosci. 2017 Nov 15;37(46):11151-11165
pubmed: 29038245
J Cell Biol. 2008 Nov 3;183(3):513-26
pubmed: 18981234
Biochim Biophys Acta. 2009 Apr;1793(4):726-36
pubmed: 19111580
J Biol Chem. 2001 Jul 27;276(30):28212-8
pubmed: 11337491
EMBO J. 2008 Sep 17;27(18):2432-43
pubmed: 18701920
Cell Mol Life Sci. 2013 Jan;70(1):121-36
pubmed: 22773119
J Clin Neurol. 2011 Dec;7(4):215-22
pubmed: 22259618
Cell Tissue Res. 2018 Jul;373(1):9-20
pubmed: 29536161
Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):571-6
pubmed: 10639120
Hum Mol Genet. 2019 May 15;28(10):1645-1660
pubmed: 30629163
Ageing Res Rev. 2014 Mar;14:19-30
pubmed: 24503004
Hum Mol Genet. 2017 Feb 15;26(4):729-741
pubmed: 28115417
J Biol Chem. 2010 May 28;285(22):16814-21
pubmed: 20363736
J Cell Sci. 2016 Jan 15;129(2):329-40
pubmed: 26627821
JAMA Neurol. 2015 Jan;72(1):100-5
pubmed: 25401511
Neurobiol Aging. 2018 Jul;67:189-200
pubmed: 29735433
Acta Neuropathol. 2007 Nov;114(5):481-9
pubmed: 17653558
EMBO Mol Med. 2012 May;4(5):380-95
pubmed: 22407749
Exp Neurol. 2003 Jan;179(1):9-16
pubmed: 12504863
J Neurochem. 2007 Jul;102(1):93-102
pubmed: 17394548
Hum Mol Genet. 2007 Jan 15;16(2):223-32
pubmed: 17200152
Ann Clin Transl Neurol. 2015 Apr;2(4):433-8
pubmed: 25909088
J Neurosci. 2004 Feb 25;24(8):1888-96
pubmed: 14985429
Brain. 2017 Dec 1;140(12):3191-3203
pubmed: 29140481
J Cell Sci. 2019 Jun 3;132(11):
pubmed: 31085713
J Neurochem. 2019 Sep;150(5):577-590
pubmed: 31069800
Biochem Soc Trans. 2012 Dec 1;40(6):1368-72
pubmed: 23176482
Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16842-7
pubmed: 16269541
Exp Neurol. 2017 Dec;298(Pt B):236-245
pubmed: 28764903
Curr Biol. 2001 Oct 30;11(21):1680-5
pubmed: 11696325
Nat Med. 2008 May;14(5):504-6
pubmed: 18391962
Exp Cell Res. 2007 Oct 1;313(16):3658-70
pubmed: 17706965
J Biol Chem. 2015 Nov 13;290(46):27660-79
pubmed: 26381411
EMBO J. 2013 Feb 6;32(3):324-39
pubmed: 23258225
ASN Neuro. 2009 Apr 14;1(1):
pubmed: 19570025
J Neurosci. 2009 Oct 28;29(43):13578-88
pubmed: 19864570
Nat Genet. 2014 Sep;46(9):989-93
pubmed: 25064009
Mol Biol Cell. 2002 Sep;13(9):3268-80
pubmed: 12221131
EMBO J. 1994 Dec 1;13(23):5547-58
pubmed: 7988552
Hum Mol Genet. 2015 Nov 1;24(21):6013-28
pubmed: 26251043
J Neurosci. 2013 Feb 6;33(6):2605-15
pubmed: 23392688
J Biol Chem. 2006 Jan 13;281(2):1099-106
pubmed: 16282324
Ann Neurol. 2004 Oct;56(4):586-90
pubmed: 15455439
Hum Mol Genet. 2019 Oct 1;28(19):3232-3243
pubmed: 31261377
Mov Disord. 2020 Jan;35(1):134-141
pubmed: 31505072
J Biol Chem. 1998 Apr 17;273(16):9443-9
pubmed: 9545270
Front Neurol. 2018 Oct 02;9:809
pubmed: 30333786
J Neurochem. 2003 Mar;84(5):1051-65
pubmed: 12603829
Elife. 2017 Apr 10;6:
pubmed: 28394250
Neurobiol Dis. 2006 Aug;23(2):329-41
pubmed: 16750377
EMBO J. 2002 Mar 15;21(6):1289-300
pubmed: 11889035
Mol Biol Cell. 2003 Jan;14(1):129-41
pubmed: 12529432
Mol Biol Cell. 2000 Feb;11(2):467-80
pubmed: 10679007
Cell Res. 2014 Jan;24(1):92-104
pubmed: 24281265
Biochem Biophys Res Commun. 2007 Jun 8;357(3):668-71
pubmed: 17442267
Stem Cell Reports. 2019 May 14;12(5):878-889
pubmed: 30982740
Neurobiol Aging. 2013 Dec;34(12):2890.e13-5
pubmed: 23871123
Sci Rep. 2017 Aug 31;7(1):10300
pubmed: 28860483
J Biol Chem. 2002 Feb 22;277(8):6344-52
pubmed: 11744721
J Neurosci. 2017 Oct 11;37(41):9799-9807
pubmed: 29021297
J Biol Chem. 2003 Jul 4;278(27):25009-13
pubmed: 12719433
J Biol Chem. 2008 Aug 29;283(35):23542-56
pubmed: 18566453
FASEB J. 2005 Apr;19(6):533-42
pubmed: 15791003
Mol Neurodegener. 2018 Feb 13;13(1):8
pubmed: 29439717
J Biol Chem. 2018 Apr 13;293(15):5414-5424
pubmed: 29247007
Biochim Biophys Acta. 1983 Jan 7;750(1):178-84
pubmed: 6824712
EMBO J. 2018 Jan 17;37(2):235-254
pubmed: 29158324
N Engl J Med. 2006 Jan 26;354(4):424-5
pubmed: 16436782
Am J Pathol. 2013 Feb;182(2):474-84
pubmed: 23231918
J Neuropathol Exp Neurol. 2004 Apr;63(4):323-8
pubmed: 15099022
J Neuropathol Exp Neurol. 2009 Jul;68(7):816-22
pubmed: 19535990
Biochem Biophys Res Commun. 2013 Nov 29;441(4):862-6
pubmed: 24211199
Hum Mol Genet. 2012 Feb 1;21(3):511-25
pubmed: 22012985
Neurology. 2006 Oct 24;67(8):1476-8
pubmed: 17060578
Elife. 2017 Jun 07;6:
pubmed: 28590904
Aging Cell. 2018 Feb;17(1):
pubmed: 29024336
Neurobiol Dis. 2019 Apr;124:230-239
pubmed: 30448284
Genes Cells. 2006 Sep;11(9):1023-37
pubmed: 16923123
J Biol Chem. 2006 Oct 6;281(40):29739-52
pubmed: 16847063
Biochem J. 2007 Jul 15;405(2):307-17
pubmed: 17447891
Mov Disord. 2012 Jun;27(7):831-42
pubmed: 22451330
J Lipid Res. 1992 Feb;33(2):141-66
pubmed: 1569369