SERT interacting proteins
SERT regulation
autism spectrum disorder (ASD)
quantitative proteomic analysis
serotonin transporter
Journal
Frontiers in molecular neuroscience
ISSN: 1662-5099
Titre abrégé: Front Mol Neurosci
Pays: Switzerland
ID NLM: 101477914
Informations de publication
Date de publication:
2020
2020
Historique:
received:
04
02
2020
accepted:
28
04
2020
entrez:
26
6
2020
pubmed:
26
6
2020
medline:
26
6
2020
Statut:
epublish
Résumé
Altered serotonin (5-HT) signaling is associated with multiple brain disorders, including major depressive disorder (MDD), obsessive-compulsive disorder (OCD), and autism spectrum disorder (ASD). The presynaptic, high-affinity 5-HT transporter (SERT) tightly regulates 5-HT clearance after release from serotonergic neurons in the brain and enteric nervous systems, among other sites. Accumulating evidence suggests that SERT is dynamically regulated in distinct activity states as a result of environmental and intracellular stimuli, with regulation perturbed by disease-associated coding variants. Our lab identified a rare, hypermorphic SERT coding substitution, Gly56Ala, in subjects with ASD, finding that the Ala56 variant stabilizes a high-affinity outward-facing conformation (SERT
Identifiants
pubmed: 32581705
doi: 10.3389/fnmol.2020.00089
pmc: PMC7295033
doi:
Types de publication
Journal Article
Langues
eng
Pagination
89Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK058404
Pays : United States
Organisme : NIMH NIH HHS
ID : P50 MH096972
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH094527
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007628
Pays : United States
Informations de copyright
Copyright © 2020 Quinlan, Robson, Ye, Rose, Schey and Blakely.
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