MicroRNA-146a Is a Wide-Reaching Neuroinflammatory Regulator and Potential Treatment Target in Neurological Diseases.
biomarker
microRNA-146a
neuroinflammation
neurological diseases
single-nucleotide polymorphisms
Journal
Frontiers in molecular neuroscience
ISSN: 1662-5099
Titre abrégé: Front Mol Neurosci
Pays: Switzerland
ID NLM: 101477914
Informations de publication
Date de publication:
2020
2020
Historique:
received:
20
02
2020
accepted:
29
04
2020
entrez:
26
6
2020
pubmed:
26
6
2020
medline:
26
6
2020
Statut:
epublish
Résumé
Progressive functional deterioration and loss of neurons underlies neurological diseases and constitutes an important cause of disability and death worldwide. The causes of various types of neurological diseases often share several critical nerve-related cellular mechanisms and pathological features, particularly the neuroinflammatory response in the nervous system. A rapidly growing body of evidence indicates that various microRNAs play pivotal roles in these processes in neurological diseases and might be viable therapeutic targets. Among these microRNAs, microRNA-146a (miR-146a) stands out due to the rapid increase in recent literature on its mechanistic involvement in neurological diseases. In this review, we summarize and highlight the critical role of miR-146a in neurological diseases. MiR-146a polymorphisms are associated with the risk of neurological disease. Alterations in miR-146a expression levels are crucial events in the pathogenesis of numerous neurological diseases that are spatially and temporally diverse. Additionally, the target genes of miR-146a are involved in the regulation of pathophysiological processes in neurological diseases, particularly the neuroinflammatory response. In summary, miR-146a mainly plays a critical role in neuroinflammation during the progression of neurological diseases and might be a prospective biomarker and therapeutic target. Understanding the mechanisms by which miR-146a affects the neuroinflammatory response in different neurological injuries, different cell types, and even different stages of certain neurological diseases will pave the way for its use as a therapeutic target in neurodegenerative diseases.
Identifiants
pubmed: 32581706
doi: 10.3389/fnmol.2020.00090
pmc: PMC7291868
doi:
Types de publication
Journal Article
Langues
eng
Pagination
90Informations de copyright
Copyright © 2020 Fan, Liang, Ou, Zou, Sun, Zhou and Cui.
Références
Biochem J. 2008 Jun 1;412(2):191-209
pubmed: 18466116
Front Cell Neurosci. 2014 Mar 13;8:73
pubmed: 24659953
Trends Neurosci. 1999 Sep;22(9):391-7
pubmed: 10441299
Adv Neurobiol. 2017;15:335-364
pubmed: 28674988
J Neurotrauma. 2019 Mar 19;36(6):845-852
pubmed: 30122113
Mol Med Rep. 2018 Apr;17(4):5356-5361
pubmed: 29363732
J Biol Chem. 2008 Nov 14;283(46):31315-22
pubmed: 18801740
Biochemistry. 2013 Jun 11;52(23):3949-62
pubmed: 23701234
Mol Med Rep. 2015 Sep;12(3):4037-4042
pubmed: 26095531
Sci Rep. 2016 May 25;6:26697
pubmed: 27221467
RNA Biol. 2011 Nov-Dec;8(6):1005-21
pubmed: 22048026
J Alzheimers Dis Parkinsonism. 2017 Apr;7(2):
pubmed: 29051843
J Neurosci. 2013 May 22;33(21):9013-20
pubmed: 23699512
Microrna. 2015;4(3):185-93
pubmed: 26634350
Nat Rev Neurol. 2011 Sep 13;7(10):573-83
pubmed: 21912405
Seizure. 2016 Aug;40:21-6
pubmed: 27310665
Neurol Sci. 2018 Feb;39(2):297-304
pubmed: 29127522
Front Aging Neurosci. 2016 Jun 14;8:140
pubmed: 27378912
Nat Rev Neurol. 2011 Jan;7(1):31-40
pubmed: 21135885
J Neuroimmunol. 2018 Oct 15;323:56-61
pubmed: 30196835
Sci Rep. 2015 Mar 31;5:9522
pubmed: 25825351
Curr Neurovasc Res. 2015;12(3):214-21
pubmed: 26044809
J Autoimmun. 2014 Aug;52:101-12
pubmed: 24439114
J Inorg Biochem. 2009 Nov;103(11):1591-5
pubmed: 19540598
Prog Neurobiol. 2019 Nov;182:101664
pubmed: 31356849
Neurosci Lett. 2009 Aug 7;459(2):100-4
pubmed: 19406203
Biol Res. 2011;44(1):89-105
pubmed: 21720686
Inflammation. 2017 Aug;40(4):1460-1473
pubmed: 28523463
J Biol Chem. 2014 Jul 11;289(28):19508-18
pubmed: 24828499
Cell Biochem Funct. 2016 Oct;34(7):511-515
pubmed: 27748571
Kaohsiung J Med Sci. 2017 Aug;33(8):369-378
pubmed: 28811005
Med Hypotheses. 2018 Aug;117:21-27
pubmed: 30077189
Exp Neurol. 2015 Mar;265:84-93
pubmed: 25562527
Curr Mol Med. 2011 Apr;11(3):246-54
pubmed: 21375489
Immunology. 2015 Jan;144(1):56-67
pubmed: 24962817
Diabetes. 2017 Dec;66(12):3111-3121
pubmed: 28899883
Mol Neurobiol. 2016 Mar;53(2):1322-1328
pubmed: 25631714
Mol Neurobiol. 2019 Sep;56(9):6156-6167
pubmed: 30734227
Acta Neuropathol. 2019 May;137(5):689-691
pubmed: 30968314
Neuroscience. 2017 Apr 21;348:252-263
pubmed: 28237816
Diabetes Care. 2017 Jan;40(1):136-154
pubmed: 27999003
Neurobiol Aging. 2014 Jan;35(1):152-8
pubmed: 23962497
PLoS One. 2014 Dec 12;9(12):e115209
pubmed: 25500583
Neuroreport. 2009 Oct 28;20(16):1500-5
pubmed: 19801956
Curr Opin Neurol. 2014 Apr;27(2):199-205
pubmed: 24553459
Brain Res. 2016 Oct 1;1648(Pt A):136-143
pubmed: 27449900
Clin Neuropharmacol. 2001 Sep-Oct;24(5):254-64
pubmed: 11586110
Neuron. 2016 May 18;90(4):724-39
pubmed: 27196974
PLoS Genet. 2015 Dec 17;11(12):e1005710
pubmed: 26681446
Sci Rep. 2015 Sep 18;5:14143
pubmed: 26382856
Curr Pharm Des. 2014;20(38):6022-7
pubmed: 24641229
Mol Cell Neurosci. 2016 Mar;71:13-24
pubmed: 26658803
PLoS One. 2011;6(8):e23837
pubmed: 21887328
Biomed Pharmacother. 2017 Dec;96:238-245
pubmed: 28987948
Pathogens. 2017 Dec 01;6(4):
pubmed: 29194372
FEBS Lett. 2011 Dec 1;585(23):3770-80
pubmed: 21550344
Neurobiol Dis. 2012 Sep;47(3):407-15
pubmed: 22579772
PLoS One. 2015 Jul 24;10(7):e0133783
pubmed: 26207814
Acta Neuropathol Commun. 2015 Dec 18;3:86
pubmed: 26682910
Acta Neuropathol. 2015 Jun;129(6):775-88
pubmed: 25792358
J Neuroinflammation. 2015 Feb 18;12:30
pubmed: 25889446
Mol Neurobiol. 2018 May;55(5):4207-4224
pubmed: 28612258
J Neurol Sci. 2017 Sep 15;380:58-63
pubmed: 28870590
Eur Rev Med Pharmacol Sci. 2018 May;22(9):2809-2816
pubmed: 29771433
Nat Rev Cancer. 2013 Jun;13(6):397-411
pubmed: 23702928
Lab Med. 2019 Jan 1;50(1):34-41
pubmed: 30060033
PLoS One. 2012;7(2):e30832
pubmed: 22363497
Cell Physiol Biochem. 2015;35(1):281-91
pubmed: 25591770
Brain Res Mol Brain Res. 2000 Feb 22;75(2):216-24
pubmed: 10686342
Herpes. 2006 Aug;13(2):53-5
pubmed: 16895657
Exp Ther Med. 2018 Oct;16(4):3703-3709
pubmed: 30233729
J Infect Dis. 2002 Apr 15;185(8):1174-8
pubmed: 11930329
FASEB J. 2010 Jul;24(7):2292-300
pubmed: 20181935
Science. 1993 May 21;260(5111):1130-2
pubmed: 8493557
Exp Cell Res. 2016 May 1;343(2):248-257
pubmed: 27038654
Mol Brain. 2013 May 24;6:26
pubmed: 23705811
J Cereb Blood Flow Metab. 2015 Mar;35(3):412-23
pubmed: 25515214
Mol Cell Biol. 2000 May;20(9):3178-86
pubmed: 10757802
Viruses. 2019 Jan 15;11(1):
pubmed: 30650564
J Trauma Acute Care Surg. 2017 Jul;83(1 Suppl 1):S145-S149
pubmed: 28452880
PLoS One. 2014 Feb 25;9(2):e89019
pubmed: 24586483
Nanomedicine. 2019 Apr;17:188-197
pubmed: 30721753
Blood Cells Mol Dis. 2005 Sep-Oct;35(2):89-93
pubmed: 15990342
Neurosci Lett. 2013 Oct 25;555:85-90
pubmed: 24036458
Biomed Res Int. 2016;2016:4013487
pubmed: 27830143
Neurology. 1984 Jul;34(7):939-44
pubmed: 6610841
Front Neurol. 2018 Mar 29;9:201
pubmed: 29651272
Mult Scler. 2017 Nov;23(13):1716-1726
pubmed: 28067602
PLoS One. 2011;6(9):e24604
pubmed: 21949733
N Engl J Med. ;376(13):e25
pubmed: 28357848
Exp Neurol. 2012 Jun;235(2):484-90
pubmed: 22138609
J Alzheimers Dis. 2016 Apr 16;52(4):1321-33
pubmed: 27104900
Neuroscience. 2016 Aug 4;329:43-53
pubmed: 27167084
Lancet Neurol. 2012 Jan;11(1):101-18
pubmed: 22172625
FEBS J. 2010 Jul;277(14):3051-67
pubmed: 20573181
CNS Neurol Disord Drug Targets. 2017;16(6):686-693
pubmed: 28474544
Seizure. 2015 Apr;27:60-5
pubmed: 25891929
Mil Med Res. 2019 Apr 30;6(1):12
pubmed: 31036067
Neurochem Int. 2017 Jul;107:156-167
pubmed: 28202285
Mediators Inflamm. 2017;2017:6512620
pubmed: 28242958
J Toxicol Environ Health A. 2011;74(22-24):1460-8
pubmed: 22043907
Biosci Rep. 2018 Jan 19;38(1):
pubmed: 29187582
Front Cell Neurosci. 2019 Aug 06;13:357
pubmed: 31447647
Mol Ther Nucleic Acids. 2019 Dec 6;18:681-695
pubmed: 31707205
Biochem Biophys Res Commun. 2010 Jun 4;396(3):742-7
pubmed: 20451497
Dis Markers. 2015;2015:625659
pubmed: 26078483
Neuroscience. 2014 Feb 14;259:155-63
pubmed: 24316060
J Neurochem. 2016 Oct;139 Suppl 1:318-324
pubmed: 27401947
Arch Virol. 2017 Jun;162(6):1495-1505
pubmed: 28190197
Neurotherapeutics. 2010 Jan;7(1):22-30
pubmed: 20129494
Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):1856-64
pubmed: 22723435
Neurosci Lett. 2011 Jul 20;499(2):109-13
pubmed: 21640790
Front Mol Neurosci. 2015 Mar 02;8:5
pubmed: 25784854
eNeurologicalSci. 2018 Sep 14;13:1-4
pubmed: 30255159
Aging Dis. 2013 Oct 01;4(5):295-310
pubmed: 24124634
Mov Disord. 2020 Mar;35(3):401-408
pubmed: 31724242
Clin Interv Aging. 2018 Sep 12;13:1709-1726
pubmed: 30254431
Front Mol Neurosci. 2016 Dec 21;9:149
pubmed: 28066176
Nucleic Acids Res. 2010 Nov;38(20):7219-35
pubmed: 20591823
FEBS Lett. 2016 Jul;590(14):2190-200
pubmed: 27241555
J Cereb Blood Flow Metab. 2006 Nov;26(11):1407-18
pubmed: 16538231
Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12481-6
pubmed: 16885212
Mol Neurobiol. 2019 Mar;56(3):2137-2158
pubmed: 29995256
Eur J Neurosci. 2010 Mar;31(6):1100-7
pubmed: 20214679
Prog Neurobiol. 2007 Nov;83(4):228-48
pubmed: 17467140
Microbes Infect. 2010 Jan;12(1):37-45
pubmed: 19786116
PLoS One. 2017 Jan 3;12(1):e0169081
pubmed: 28045967
Semin Cancer Biol. 2008 Apr;18(2):131-40
pubmed: 18291670
Front Biosci. 2006 Jan 01;11:718-32
pubmed: 16146764
Dis Model Mech. 2018 Mar 23;11(3):
pubmed: 29590637