G Protein-Coupled Receptors in the Mammalian Blood-Brain Barrier.
G-protein coupled receptors
blood-brain barrier
drug development
neurodegenerative disease
neurovascular unit
Journal
Frontiers in cellular neuroscience
ISSN: 1662-5102
Titre abrégé: Front Cell Neurosci
Pays: Switzerland
ID NLM: 101477935
Informations de publication
Date de publication:
2020
2020
Historique:
received:
06
02
2020
accepted:
22
04
2020
entrez:
26
6
2020
pubmed:
26
6
2020
medline:
26
6
2020
Statut:
epublish
Résumé
The mammalian neurovascular unit (NVU) is comprised of neurons, glia, and vascular cells. The NVU is the nexus between the cardiovascular and central nervous system (CNS). The central component of the NVU is the blood-brain barrier (BBB) which consists of a monolayer of tightly connected endothelial cells covered by pericytes and further surrounded by astrocytic endfeet. In addition to preventing the diffusion of toxic species into the CNS, the BBB endothelium serves as a dynamic regulatory system facilitating the transport of molecules from the bloodstream to the brain and vis versa. The structural integrity and transport functions of the BBB are maintained, in part, by an orchestra of membrane receptors and transporters including members of the superfamily of G protein-coupled receptors (GPCRs). Here, we provide an overview of GPCRs known to regulate mammalian BBB structure and function and discuss how dysregulation of these pathways plays a role in various neurodegenerative diseases.
Identifiants
pubmed: 32581715
doi: 10.3389/fncel.2020.00139
pmc: PMC7283493
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
139Subventions
Organisme : NIA NIH HHS
ID : R01 AG061288
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS110687
Pays : United States
Organisme : NIA NIH HHS
ID : R03 AG063287
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG066090
Pays : United States
Informations de copyright
Copyright © 2020 Pluimer, Colt and Zhao.
Références
J Immunol. 2008 Nov 1;181(9):6406-16
pubmed: 18941231
CNS Neurosci Ther. 2015 Mar;21(3):271-9
pubmed: 25495836
Annu Rev Cell Dev Biol. 2004;20:781-810
pubmed: 15473860
Nat Neurosci. 2015 Apr;18(4):521-530
pubmed: 25730668
Nat Med. 2013 Dec;19(12):1584-96
pubmed: 24309662
Proc Natl Acad Sci U S A. 1987 May;84(10):3434-8
pubmed: 3033647
Sci Rep. 2015 Dec 09;5:17956
pubmed: 26648273
Neurosci Conscious. 2019 Apr 21;2019(1):niz003
pubmed: 31024740
Neuropharmacology. 1986 Feb;25(2):161-7
pubmed: 2939361
Nature. 2018 Feb 22;554(7693):475-480
pubmed: 29443965
Cell Rep. 2018 Jun 12;23(11):3170-3182
pubmed: 29898390
Br J Pharmacol. 2012 May;166(1):1-3
pubmed: 22489621
Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15930-5
pubmed: 22949658
Pharmacol Rev. 2016 Apr;68(2):264-355
pubmed: 26841800
Acta Pharmacol Sin. 2012 Mar;33(3):363-71
pubmed: 22367282
Dis Model Mech. 2017 May 1;10(5):499-502
pubmed: 28468935
Acta Pharmacol Sin. 2012 Mar;33(3):312-23
pubmed: 22286915
Nature. 2003 Sep 4;425(6953):93-8
pubmed: 12955148
Brain Inj. 2019;33(6):734-819
pubmed: 30938196
Biochem Soc Trans. 2013 Feb 1;41(1):154-8
pubmed: 23356276
Cell Signal. 2019 Jan;53:151-161
pubmed: 30290210
PLoS One. 2015 Mar 30;10(3):e0120074
pubmed: 25822252
Front Pharmacol. 2012 Jun 29;3:121
pubmed: 22754527
Clin Neuropharmacol. 2010 Mar-Apr;33(2):91-101
pubmed: 20061941
J Neuroinflammation. 2012 Jun 20;9:133
pubmed: 22715976
Curr Pharm Biotechnol. 2009 Apr;10(3):317-26
pubmed: 19355942
J Neuroinflammation. 2018 Jul 4;15(1):196
pubmed: 29973231
Cell. 2005 Oct 7;123(1):9-12
pubmed: 16213208
Nat Med. 2017 Apr;23(4):450-460
pubmed: 28288111
Cell. 2015 Nov 19;163(5):1064-1078
pubmed: 26590417
Biochem Biophys Res Commun. 2018 Jul 2;501(4):1048-1054
pubmed: 29778535
Neuroscience. 2017 May 14;350:146-157
pubmed: 28344073
Nature. 2014 Jun 5;510(7503):121-5
pubmed: 24847886
Invest Ophthalmol Vis Sci. 2016 May 1;57(6):2584-92
pubmed: 27163772
Mol Pharmacol. 2012 Nov;82(5):777-83
pubmed: 22821233
Nature. 2013 Feb 14;494(7436):185-94
pubmed: 23407534
Int J Biol Macromol. 2018 Jul 15;114:1325-1337
pubmed: 29604355
Cereb Cortex. 2014 Oct;24(10):2784-95
pubmed: 23696276
Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4531-4536
pubmed: 28396408
Adv Exp Med Biol. 2010;706:157-66
pubmed: 21618835
Nat Commun. 2017 May 23;8:15557
pubmed: 28534495
Mol Endocrinol. 2007 Mar;21(3):700-11
pubmed: 17170072
Br J Pharmacol. 2015 Dec;172(24):5744-869
pubmed: 26650439
Science. 2010 Nov 12;330(6006):985-9
pubmed: 21071672
Neuron. 2017 Aug 30;95(5):1056-1073.e5
pubmed: 28803732
Nat Rev Neurosci. 2011 Nov 03;12(12):723-38
pubmed: 22048062
Nat Commun. 2020 Jan 21;11(1):414
pubmed: 31964872
PLoS One. 2011;6(11):e27586
pubmed: 22110680
Neuropharmacology. 2018 Aug;138:381-392
pubmed: 29894771
J Lipid Res. 2014 Aug;55(8):1596-608
pubmed: 24459205
J Neurochem. 1997 Mar;68(3):991-1000
pubmed: 9048744
Nat Rev Drug Discov. 2014 Jul;13(7):513-32
pubmed: 24981364
Front Endocrinol (Lausanne). 2011 Oct 25;2:51
pubmed: 22654812
Circ Res. 2016 Mar 4;118(5):881-97
pubmed: 26941424
Nat Rev Drug Discov. 2019 Nov;18(11):869-884
pubmed: 31462748
Physiol Rev. 2019 Jan 1;99(1):21-78
pubmed: 30280653
J Biol Chem. 1990 Jun 5;265(16):9308-13
pubmed: 2160972
Mol Biol Evol. 2009 Jan;26(1):71-84
pubmed: 18845549
Bioorg Med Chem Lett. 2007 Jan 15;17(2):491-4
pubmed: 17070046
Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):641-6
pubmed: 19129494
Nat Rev Drug Discov. 2013 Jan;12(1):25-34
pubmed: 23237917
Gastroenterol Res Pract. 2019 Apr 09;2019:3784172
pubmed: 31093274
J Mol Neurosci. 2016 Jun;59(2):211-9
pubmed: 26659380
Cell. 2005 Oct 7;123(1):133-44
pubmed: 16213218
Cell Signal. 2007 Aug;19(8):1745-53
pubmed: 17462861
Neuromolecular Med. 2014 Sep;16(3):620-42
pubmed: 24929655
Handb Exp Pharmacol. 2016;234:15-41
pubmed: 27832482
Mediators Inflamm. 2017;2017:3454212
pubmed: 28607533
J Neurosci. 2013 Jan 23;33(4):1660-71
pubmed: 23345238
PLoS One. 2015 Sep 22;10(9):e0137949
pubmed: 26394398
Front Neurosci. 2014 Dec 16;8:414
pubmed: 25565944
Arterioscler Thromb Vasc Biol. 2008 Aug;28(8):1469-76
pubmed: 18483404
Fluids Barriers CNS. 2015 Mar 05;12:7
pubmed: 25763180
J Neurosci. 2012 Mar 21;32(12):4004-16
pubmed: 22442067
Neuron. 2013 Nov 20;80(4):844-66
pubmed: 24267647
Mol Cell Biol. 2007 Feb;27(4):1334-47
pubmed: 17145776
Tissue Barriers. 2017 Jul 3;5(3):e1339768
pubmed: 28632993
Science. 2011 Dec 23;334(6063):1727-31
pubmed: 22144466
J Cell Biol. 2011 Jan 24;192(2):307-19
pubmed: 21242289
Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2138-43
pubmed: 22308440
Nat Chem Biol. 2017 Nov;13(11):1143-1151
pubmed: 29045379
Cell Rep. 2015 Jan 13;10(2):123-30
pubmed: 25558062
Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5759-64
pubmed: 21421844