The Basal Forebrain Modulates Neuronal Response in an Active Olfactory Discrimination Task.
acetylcholine
anticipation
attention
discrimination
go/no–go
in vivo
Journal
Frontiers in cellular neuroscience
ISSN: 1662-5102
Titre abrégé: Front Cell Neurosci
Pays: Switzerland
ID NLM: 101477935
Informations de publication
Date de publication:
2020
2020
Historique:
received:
04
03
2020
accepted:
27
04
2020
entrez:
26
6
2020
pubmed:
26
6
2020
medline:
26
6
2020
Statut:
epublish
Résumé
Successful completion of sensory decision-making requires focusing on relevant stimuli, adequate signal/noise ratio for stimulus discrimination, and stimulus valence evaluation. Different brain regions are postulated to play a role in these computations; however, evidence suggests that sensory and decision-making circuits are required to interact through a common neuronal pathway to elicit a context-adequate behavioral response. Recently, the basal forebrain (BF) region has emerged as a good candidate, since its heterogeneous projecting neurons innervate most of the cortical mantle and sensory processing circuits modulating different aspects of the sensory decision-making process. Moreover, evidence indicates that the BF plays an important role in attention and in fast modulation of neuronal activity that enhance visual and olfactory sensory perception. Here, we study in awake mice the involvement of BF in initiation and completion of trials in a reward-driven olfactory detection task. Using tetrode recordings, we find that BF neurons (including cholinergics) are recruited during sensory discrimination, reward, and interestingly slightly before trial initiation in successful discrimination trials. The precue neuronal activity was correlated with animal performance, indicating that this circuit could play an important role in adaptive context-dependent behavioral responses.
Identifiants
pubmed: 32581716
doi: 10.3389/fncel.2020.00141
pmc: PMC7289987
doi:
Types de publication
Journal Article
Langues
eng
Pagination
141Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC008855
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS095311
Pays : United States
Organisme : NINDS NIH HHS
ID : P30 NS048154
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS086839
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC000566
Pays : United States
Informations de copyright
Copyright © 2020 Nunez-Parra, Cea-Del Rio, Huntsman and Restrepo.
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