Regulatory T Cells as a Novel Candidate for Cell-Based Therapy in Kidney Disease.
M2c macrophage
Treg
cell-based therapy
kidney injury
regulatory T cell
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2020
2020
Historique:
received:
07
04
2020
accepted:
18
05
2020
entrez:
26
6
2020
pubmed:
26
6
2020
medline:
26
6
2020
Statut:
epublish
Résumé
Kidney disease is a significant health concern worldwide. Ineffective treatment can lead to disastrous consequences, such as organ failure and death. Research has turned to cell-based therapy, but has yet to produce an effective and reliable treatment for kidney disease. To address this problem, we examined four datasets of gene expression profiles from diseased and healthy kidney tissue in humans, mice, and rats. Differentially expressed genes (DEGs) were screened and subjected to enrichment analyses. Up-regulated genes in diseased kidney tissue were significantly enriched in pathways associated with regulatory T cells (Tregs). Analysis with the xCell tool showed that Tregs were generally increased in diseased kidney tissue in all species. To validate these results
Identifiants
pubmed: 32581852
doi: 10.3389/fphys.2020.00621
pmc: PMC7296170
doi:
Types de publication
Journal Article
Langues
eng
Pagination
621Informations de copyright
Copyright © 2020 Lu, Zhang, Chen, Chen, Li and Liao.
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