Time Course of Immune Response and Immunomodulation During Normal and Delayed Healing of Musculoskeletal Wounds.
Animals
Bone Regeneration
/ immunology
Bony Callus
/ immunology
Fracture Healing
/ immunology
Hematoma
/ immunology
Humans
Immunomodulation
Inflammation
/ immunology
Multiple Trauma
/ immunology
Muscle, Skeletal
/ immunology
Musculoskeletal System
/ immunology
Regeneration
/ immunology
Time Factors
Wound Healing
/ immunology
delayed fracture healing
dysregulated inflammatory response
fracture healing
osteoimmunology
wound healing
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
28
01
2020
accepted:
01
05
2020
entrez:
26
6
2020
pubmed:
26
6
2020
medline:
30
3
2021
Statut:
epublish
Résumé
Single trauma injuries or isolated fractures are often manageable and generally heal without complications. In contrast, high-energy trauma results in multi/poly-trauma injury patterns presenting imbalanced pro- and anti- inflammatory responses often leading to immune dysfunction. These injuries often exhibit delayed healing, leading to fibrosis of injury sites and delayed healing of fractures depending on the intensity of the compounding traumas. Immune dysfunction is accompanied by a temporal shift in the innate and adaptive immune cells distribution, triggered by the overwhelming release of an arsenal of inflammatory mediators such as complements, cytokines and damage associated molecular patterns (DAMPs) from necrotic cells. Recent studies have implicated this dysregulated inflammation in the poor prognosis of polytraumatic injuries, however, interventions focusing on immunomodulating inflammatory cellular composition and activation, if administered incorrectly, can result in immune suppression and unintended outcomes. Immunomodulation therapy is promising but should be conducted with consideration for the spatial and temporal distribution of the immune cells during impaired healing. This review describes the current state of knowledge in the spatiotemporal distribution patterns of immune cells at various stages during musculoskeletal wound healing, with a focus on recent advances in the field of Osteoimmunology, a study of the interface between the immune and skeletal systems, in long bone fractures. The goals of this review are to (1) discuss wound and fracture healing processes of normal and delayed healing in skeletal muscles and long bones; (2) provide a balanced perspective on temporal distributions of immune cells and skeletal cells during healing; and (3) highlight recent therapeutic interventions used to improve fracture healing. This review is intended to promote an understanding of the importance of inflammation during normal and delayed wound and fracture healing. Knowledge gained will be instrumental in developing novel immunomodulatory approaches for impaired healing.
Identifiants
pubmed: 32582170
doi: 10.3389/fimmu.2020.01056
pmc: PMC7287024
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1056Informations de copyright
Copyright © 2020 Muire, Mangum and Wenke.
Références
J Inflamm Res. 2016 May 18;9:69-78
pubmed: 27274302
BMC Musculoskelet Disord. 2016 Sep 05;17(1):383
pubmed: 27596101
Burns. 2002 Nov;28(7):665-9
pubmed: 12417162
J Bone Miner Res. 2017 Sep;32(9):1870-1883
pubmed: 28556967
J Orthop Res. 2011 May;29(5):734-9
pubmed: 21437953
J Bone Miner Res. 2016 Nov;31(11):1997-2000
pubmed: 27207251
Tissue Eng Part B Rev. 2010 Aug;16(4):427-34
pubmed: 20196645
J Bone Miner Res. 2012 Nov;27(11):2231-7
pubmed: 23023946
Curr Mol Med. 2012 Jun;12(5):519-27
pubmed: 22292445
Nihon Seikeigeka Gakkai Zasshi. 1990 Oct;64(10):949-57
pubmed: 2266303
Bone. 2016 Jan;82:2-8
pubmed: 26027505
J Periodontol. 2003 Oct;74(10):1454-9
pubmed: 14653391
Int J Mol Sci. 2017 Mar 08;18(3):
pubmed: 28282868
Immunol Today. 1988 Mar;9(3):73-6
pubmed: 2978457
PLoS One. 2017 Mar 28;12(3):e0174396
pubmed: 28350850
Immunol Res. 2016 Dec;64(5-6):1195-1206
pubmed: 27629117
J Orthop Surg Res. 2019 Feb 19;14(1):58
pubmed: 30782193
J Immunol. 2012 Oct 1;189(7):3669-80
pubmed: 22933625
Histol Histopathol. 2003 Oct;18(4):1243-56
pubmed: 12973691
Biosci Trends. 2008 Dec;2(6):218-30
pubmed: 20103932
Am J Sports Med. 2005 May;33(5):745-64
pubmed: 15851777
Muscle Nerve. 1997 Feb;20(2):158-66
pubmed: 9040653
Front Immunol. 2019 Aug 16;10:1954
pubmed: 31475013
J Bone Miner Res. 2014 Feb;29(2):304-15
pubmed: 23857747
J Leukoc Biol. 2011 May;89(5):669-73
pubmed: 21208896
Biochem Soc Trans. 2017 Oct 15;45(5):1105-1115
pubmed: 28900017
Front Pharmacol. 2015 Apr 21;6:87
pubmed: 25954202
Clin Orthop Relat Res. 1998 Aug;(353):231-7
pubmed: 9728179
Front Immunol. 2020 Feb 07;11:163
pubmed: 32117297
BMC Musculoskelet Disord. 2017 Jun 12;18(1):253
pubmed: 28606129
Osteoporos Int. 2017 Jul;28(7):2207-2220
pubmed: 28341898
Injury. 2007 Sep;38 Suppl 4:S3-6
pubmed: 18224731
Ann Surg. 2012 Jun;255(6):1069-79
pubmed: 22566015
Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5866-71
pubmed: 8650184
Arch Surg. 2012 Apr;147(4):373-83
pubmed: 22508785
J Bone Joint Surg Am. 1998 Jul;80(7):985-96
pubmed: 9698003
Mol Ther. 2012 Nov;20(11):2168-79
pubmed: 23070116
Arch Orthop Trauma Surg. 2001 Jun;121(6):325-8
pubmed: 11482464
Sci Transl Med. 2013 Mar 20;5(177):177ra36
pubmed: 23515078
Shock. 2004 Jul;22(1):11-5
pubmed: 15201695
Nat Immunol. 2010 Jan;11(1):7-13
pubmed: 20016504
Br J Surg. 2012 Jan;99 Suppl 1:12-20
pubmed: 22441851
J Am Acad Orthop Surg. 2014 Mar;22(3):193-9
pubmed: 24603829
Eur Cell Mater. 2014 Jan 15;27:1-11; discussion 11-2
pubmed: 24425156
J Bone Miner Res. 2005 Jul;20(7):1114-24
pubmed: 15940364
J Trauma Acute Care Surg. 2013 Feb;74(2):489-98
pubmed: 23354243
J Bone Miner Res. 2017 Dec;32(12):2431-2444
pubmed: 28777474
Diabetologia. 2010 Feb;53(2):378-88
pubmed: 19902175
Chin J Traumatol. 2017 Feb;20(1):39-44
pubmed: 28202370
Acta Biomater. 2014 Nov;10(11):4730-4741
pubmed: 25058402
Blood. 2009 Jan 1;113(1):264-5; author reply 265
pubmed: 19122118
FEBS J. 2013 Sep;280(17):4118-30
pubmed: 23384231
Shock. 2010 Jun;33(6):568-75
pubmed: 19864971
Biochem Biophys Res Commun. 2005 Dec 16;338(2):872-9
pubmed: 16246307
Osteoporos Int. 2009 Jun;20(6):1013-21
pubmed: 19340505
Nat Rev Immunol. 2013 Mar;13(3):159-75
pubmed: 23435331
J Clin Invest. 1997 Jun 1;99(11):2691-700
pubmed: 9169499
Nat Commun. 2016 Mar 11;7:10928
pubmed: 26965320
J Cell Biol. 2011 Oct 17;195(2):307-22
pubmed: 21987635
J Mater Sci Mater Med. 2013 Jul;24(7):1799-807
pubmed: 23553569
Blood. 2010 Dec 2;116(23):4815-28
pubmed: 20713966
Clin Orthop Relat Res. 2006 Oct;451:212-7
pubmed: 16770284
J Exp Med. 2008 Jun 9;205(6):1381-93
pubmed: 18504307
Diabetol Metab Syndr. 2017 Oct 19;9:85
pubmed: 29075333
Eur J Immunol. 2014 Jun;44(6):1728-36
pubmed: 24700192
Nanomedicine. 2018 Oct;14(7):2271-2282
pubmed: 30076934
Acta Biomater. 2020 Jan 15;102:416-426
pubmed: 31760223
JBJS Rev. 2014 Oct 28;2(10):
pubmed: 27490295
J Orthop Res. 2009 Sep;27(9):1147-51
pubmed: 19382195
Int J Biochem Cell Biol. 2003 Aug;35(8):1151-6
pubmed: 12757751
J Immunol. 2008 Jul 15;181(2):1232-44
pubmed: 18606677
J Immunol. 2001 Mar 15;166(6):3789-96
pubmed: 11238621
Hawaii Med J. 2011 Oct;70(10):209-13
pubmed: 22162595
J Orthop Res. 2006 Jul;24(7):1472-9
pubmed: 16705735
FASEB J. 2011 Oct;25(10):3344-55
pubmed: 21697550
Eur Cell Mater. 2015 Sep 21;30:118-30; discussion 130-1
pubmed: 26388615
J Immunol. 2006 Sep 1;177(5):3314-26
pubmed: 16920972
Br J Pharmacol. 2007 Aug;151(7):915-29
pubmed: 17502850
J Cell Biol. 2007 Jun 4;177(5):769-79
pubmed: 17548510
Orthop Nurs. 1999 Jan-Feb;18(1):30-5
pubmed: 10223002
Arthritis Rheum. 2007 Dec;56(12):4104-12
pubmed: 18050211
Nanomedicine. 2015 Jul;11(5):1253-63
pubmed: 25791811
Front Biosci (Landmark Ed). 2014 Jun 01;19:1162-75
pubmed: 24896342
Physiol Rep. 2017 Jul;5(14):
pubmed: 28747511
Cell Metab. 2013 Aug 6;18(2):251-64
pubmed: 23931756
J Clin Invest. 2007 May;117(5):1219-22
pubmed: 17476353
Eur Cell Mater. 2016 Jul 25;32:152-62
pubmed: 27452963
J Bone Joint Surg Br. 1969 Feb 1;51(1):148-55
pubmed: 5766356
J Exp Med. 1992 Jan 1;175(1):131-8
pubmed: 1730913
J Trauma Acute Care Surg. 2013 Feb;74(2):531-7
pubmed: 23354247
Med Hypotheses. 2011 Mar;76(3):317-21
pubmed: 20961694
J Bone Joint Surg Am. 2006 Nov;88(11):2386-94
pubmed: 17079395
J Biomed Mater Res A. 2019 Feb;107(2):301-311
pubmed: 29673055
J Bone Miner Res. 2007 Jun;22(6):775-80
pubmed: 17352656
Dev Biol. 1999 Jun 15;210(2):440-55
pubmed: 10357902
Cell. 2013 Apr 11;153(2):376-88
pubmed: 23582327
Injury. 2007 May;38 Suppl 2:S11-8
pubmed: 17920412
APMIS. 2015 Nov;123(11):975-85
pubmed: 26303993
Liver Transpl. 2010 Apr;16(4):520-6
pubmed: 20373462
Stem Cells. 2008 Jan;26(1):223-34
pubmed: 17932420
Proc Natl Acad Sci U S A. 1990 Sep;87(18):7260-4
pubmed: 2169622
Front Immunol. 2018 Jun 12;9:1300
pubmed: 29946319
Microbes Infect. 2012 Jun;14(6):528-36
pubmed: 22273732
Skelet Muscle. 2011 May 04;1(1):21
pubmed: 21798099
J Orthop Trauma. 2014;28 Suppl 1:S10-4
pubmed: 24378434
J Orthop Trauma. 2016 Dec;30(12):e396-e403
pubmed: 27466826
PLoS One. 2010 Mar 04;5(3):e9539
pubmed: 20209061
Acta Orthop Scand. 2004 Jun;75(3):347-51
pubmed: 15260429
Ther Apher Dial. 2013 Jun;17(3):247-88
pubmed: 23735142
J Immunol. 2001 Sep 1;167(5):2625-31
pubmed: 11509604
Cells Tissues Organs. 2017;204(2):59-83
pubmed: 28647733
Proc Soc Exp Biol Med. 1993 Jun;203(2):221-35
pubmed: 7684844
Ann Chir Gynaecol. 1993;82(4):254-62
pubmed: 8122874
Adv Healthc Mater. 2019 Feb;8(4):e1801106
pubmed: 30328293
J Histochem Cytochem. 2000 Nov;48(11):1531-44
pubmed: 11036096
Mol Biol Cell. 1998 Apr;9(4):875-84
pubmed: 9529385
J Appl Physiol (1985). 1994 Jul;77(1):290-7
pubmed: 7961247
Bone. 2008 Aug;43(2):355-61
pubmed: 18538646
Eur J Trauma Emerg Surg. 2020 Feb;46(1):53-64
pubmed: 30820597
Sci Rep. 2016 Nov 11;6:36715
pubmed: 27833116
PLoS One. 2012;7(6):e40044
pubmed: 22768215
Injury. 2005 Jun;36(6):691-709
pubmed: 15910820
Nat Rev Rheumatol. 2012 Jan 31;8(3):133-43
pubmed: 22293759
J Bone Joint Surg Am. 1986 Dec;68(9):1389-95
pubmed: 3782211
Nat Rev Rheumatol. 2015 Jan;11(1):45-54
pubmed: 25266456
J Allergy Clin Immunol. 2016 Sep;138(3):654-665
pubmed: 27596706
Bone. 2014 Oct;67:23-32
pubmed: 24984278
Diabetologia. 2015 Mar;58(3):633-642
pubmed: 25563724
Curr Osteoporos Rep. 2017 Dec;15(6):601-608
pubmed: 29143915
Genes Dev. 1996 May 15;10(10):1173-83
pubmed: 8675005
Arthritis Rheum. 2009 Jun;60(6):1694-703
pubmed: 19479830
Front Immunol. 2019 Apr 05;10:713
pubmed: 31024548
Arch Surg. 1997 Dec;132(12):1326-30
pubmed: 9403538
Neurosci Lett. 1991 Oct 28;132(1):5-7
pubmed: 1724069
Mediators Inflamm. 2014;2014:975872
pubmed: 24771986
Arthritis Rheum. 2009 Mar;60(3):813-23
pubmed: 19248097
Blood. 2005 Mar 15;105(6):2294-9
pubmed: 15572589
Int Orthop. 2011 Sep;35(9):1267-70
pubmed: 21409368
Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16474-9
pubmed: 24065826
J Exp Orthop. 2017 Dec;4(1):5
pubmed: 28176273
Cell Tissue Res. 2012 Mar;347(3):567-73
pubmed: 21789579
Front Immunol. 2016 May 27;7:210
pubmed: 27303404
Nat Rev Immunol. 2013 Feb;13(2):88-100
pubmed: 23348415
Acta Cir Bras. 2018 Jan;33(1):31-39
pubmed: 29412231
Clin Exp Immunol. 1995 Feb;99(2):148-54
pubmed: 7531627
Exp Hematol. 2014 Jul;42(7):547-61.e4
pubmed: 24721610
Bone Joint Res. 2013 Jun 14;2(6):102-11
pubmed: 23836474
Bone. 2018 Jan;106:78-89
pubmed: 26529389
J Rehabil Res Dev. 2015;52(7):785-92
pubmed: 26745661
FEBS J. 2017 Feb;284(4):517-524
pubmed: 27479876
Int J Mol Sci. 2018 Mar 13;19(3):
pubmed: 29534011
Arthritis Res Ther. 2012 Aug 07;14(4):R181
pubmed: 22870988
Development. 2012 Aug;139(16):2845-56
pubmed: 22833472
Adv Drug Deliv Rev. 2015 Nov 1;94:3-12
pubmed: 26428617
Int J Pharm. 2018 Jan 30;536(1):241-250
pubmed: 29195917
J Oral Maxillofac Surg. 2012 Jul;70(7):1643-7
pubmed: 21958665
Int J Nanomedicine. 2015 Mar 31;10:2555-65
pubmed: 25848271
Nature. 2013 Jan 17;493(7432):346-55
pubmed: 23325217
Curr Drug Metab. 2007 Jun;8(5):519-25
pubmed: 17584023
Naunyn Schmiedebergs Arch Pharmacol. 2018 May;391(5):523-536
pubmed: 29497762
Ther Clin Risk Manag. 2015 Aug 27;11:1297-303
pubmed: 26345646
Eur J Immunol. 2001 Jul;31(7):2179-88
pubmed: 11449372
Bone. 2016 May;86:119-30
pubmed: 26946132
J Musculoskelet Neuronal Interact. 2008 Jul-Sep;8(3):204-16
pubmed: 18799853
Injury. 2014 Dec;45(12):1824-33
pubmed: 25106876
J Orthop Res. 2017 Nov;35(11):2378-2385
pubmed: 28248001
Acta Orthop. 2017 Aug;88(4):434-439
pubmed: 28508682
Blood. 2004 Dec 15;104(13):4029-37
pubmed: 15308576
J Bone Miner Res. 2010 Jun;25(6):1305-13
pubmed: 20200934
Am J Pathol. 1975 Jan;78(1):71-100
pubmed: 1109560
Immunol Rev. 2007 Dec;220:35-46
pubmed: 17979838
Injury. 2001 Jan;32(1):61-5
pubmed: 11164405
Bone. 2014 Jul;64:155-65
pubmed: 24721700
Cell Stem Cell. 2012 Aug 3;11(2):231-41
pubmed: 22862948
Nat Rev Immunol. 2019 Oct;19(10):626-642
pubmed: 31186549
Open Orthop J. 2012;6:143-9
pubmed: 22523525
J Orthop Trauma. 2005 Mar;19(3):151-7
pubmed: 15758667
Stem Cells Transl Med. 2016 Dec;5(12):1620-1630
pubmed: 27460850
J Orthop Res. 2012 Apr;30(4):581-6
pubmed: 21922535
Bioact Mater. 2017 Sep 18;3(1):129-138
pubmed: 29744450
BMJ. 2016 May 17;353:i2709
pubmed: 27189648
Nat Biotechnol. 2012 Jun 07;30(6):479
pubmed: 22678374
Am J Pathol. 2018 Mar;188(3):715-727
pubmed: 29294300
Clin Exp Pharmacol Physiol. 2017 Apr;44(4):455-462
pubmed: 28008635
J Bone Miner Res. 2000 Sep;15(9):1825-34
pubmed: 10977002
J Leukoc Biol. 2007 Jan;81(1):1-5
pubmed: 17032697
J Cell Biol. 2004 Jul 5;166(1):85-95
pubmed: 15226309
Front Physiol. 2016 Aug 05;7:341
pubmed: 27547189
J Altern Complement Med. 2004 Dec;10(6):915-6
pubmed: 15729747
J Exp Med. 2007 May 14;204(5):1057-69
pubmed: 17485518
Arthroscopy. 2015 Apr;31(4):715-8
pubmed: 25682328
Shock. 2015 Oct;44(4):371-80
pubmed: 26196844
Med Hypotheses. 2019 Feb;123:24-26
pubmed: 30696586
J Orthop Sci. 2000;5(1):64-70
pubmed: 10664441
J Bone Joint Surg Br. 2008 Aug;90(8):988-94
pubmed: 18669951
Nat Rev Immunol. 2017 Mar;17(3):165-178
pubmed: 28163303
J Biol Chem. 2000 Feb 18;275(7):4858-64
pubmed: 10671521
PLoS One. 2013 Apr 23;8(4):e62687
pubmed: 23626847
Curr Opin Immunol. 2010 Aug;22(4):507-13
pubmed: 20667703
Am J Pathol. 2014 Dec;184(12):3192-204
pubmed: 25285719
PLoS One. 2015 Jun 03;10(6):e0128094
pubmed: 26039259
Osteoporos Int. 2011 Jun;22(6):1955-65
pubmed: 20838768
J Musculoskelet Neuronal Interact. 2016 Jun 01;16(2):122-34
pubmed: 27282456