CD2 Immunobiology.

Animals CD2 Antigens / immunology Humans Immunological Synapses / immunology Lymphocyte Activation / immunology T-Lymphocytes / immunology
Alefacept CD2 CD58 LFA-3 (lymphocyte functional antigen-3) T cell activation costimulation costimulation blockade siplizumab

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2020
Historique:
received: 06 02 2020
accepted: 05 05 2020
entrez: 26 6 2020
pubmed: 26 6 2020
medline: 7 4 2021
Statut: epublish

Résumé

The glycoprotein CD2 is a costimulatory receptor expressed mainly on T and NK cells that binds to LFA3, a cell surface protein expressed on e.g., antigen-presenting cells. CD2 has an important role in the formation and organization of the immunological synapse that is formed between T cells and antigen-presenting cells upon cell-cell conjugation and associated intracellular signaling. CD2 expression is upregulated on memory T cells as well as activated T cells and plays an important role in activation of memory T cells despite the coexistence of several other costimulatory pathways. Anti-CD2 monoclonal antibodies have been shown to induce immune modulatory effects

Identifiants

DOI: 10.3389/fimmu.2020.01090 PMID: 32582179 PMC: PMC7295915
pubmed: 32582179
doi: 10.3389/fimmu.2020.01090
pmc: PMC7295915
doi:

Substances chimiques

CD2 Antigens 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1090

Informations de copyright

Copyright © 2020 Binder, Cvetkovski, Sellberg, Berg, Paternina Visbal, Sachs, Berglund and Berglund.

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Auteurs

Christian Binder (C)

Department of Immunology, Genetics and Pathology, Section of Clinical Immunology, Uppsala University, Uppsala, Sweden.
Research and Development, ITB-Med AB, Stockholm, Sweden.

Filip Cvetkovski (F)

Research and Development, ITB-Med AB, Stockholm, Sweden.

Felix Sellberg (F)

Department of Immunology, Genetics and Pathology, Section of Clinical Immunology, Uppsala University, Uppsala, Sweden.
Research and Development, ITB-Med AB, Stockholm, Sweden.

Stefan Berg (S)

Research and Development, ITB-Med AB, Stockholm, Sweden.

Horacio Paternina Visbal (H)

Department of Immunology, Genetics and Pathology, Section of Clinical Immunology, Uppsala University, Uppsala, Sweden.
Research and Development, ITB-Med AB, Stockholm, Sweden.

David H Sachs (DH)

Research and Development, ITB-Med AB, Stockholm, Sweden.
Department of Medicine, Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, United States.

Erik Berglund (E)

Research and Development, ITB-Med AB, Stockholm, Sweden.
Division of Transplantation Surgery, CLINTEC, Karolinska Institute, and Department of Transplantation Surgery, Karolinska University Hospital, Stockholm, Sweden.

David Berglund (D)

Department of Immunology, Genetics and Pathology, Section of Clinical Immunology, Uppsala University, Uppsala, Sweden.
Research and Development, ITB-Med AB, Stockholm, Sweden.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › CD2 Immunobiology.
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Antigènes CD2 › CD2 Immunobiology.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › CD2 Immunobiology.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Synapses immunologiques › CD2 Immunobiology.
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › CD2 Immunobiology.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › CD2 Immunobiology.