Carotid Disease and Ageing: A Literature Review on the Pathogenesis of Vascular Senescence in Older Subjects.
Journal
Current gerontology and geriatrics research
ISSN: 1687-7063
Titre abrégé: Curr Gerontol Geriatr Res
Pays: United States
ID NLM: 101484307
Informations de publication
Date de publication:
2020
2020
Historique:
received:
04
12
2019
revised:
11
05
2020
accepted:
16
05
2020
entrez:
26
6
2020
pubmed:
26
6
2020
medline:
26
6
2020
Statut:
epublish
Résumé
Aging is a natural process that affects all systems of the human organism, leading to its inability to adapt to environmental changes. Advancing age has been correlated with various pathological conditions, especially cardiovascular and cerebrovascular diseases. Carotid artery (CA) is mainly affected by age-induced functional and morphological alterations causing atheromatous disease. The evolvement of biomedical sciences has allowed the elucidation of many aspects of this condition. Symptomatic carotid disease (CD) derives from critical luminar stenosis or eruption of an atheromatous plaque due to structural modifications of the vessels, such as carotid intima-media thickening. At a histologic level, the aforementioned changes are mediated by elastin fragmentation, collagen deposition, immune cell infiltration, and accumulation of cytokines and vasoconstrictors. Underlying mechanisms include chronic inflammation and oxidative stress, dysregulation of cellular homeostatic systems, and senescence. Thus, there is an imbalance in components of the vessel wall, which fails to counteract exterior stress stimuli. Consequently, arterial relaxation is impaired and atherosclerotic lesions progress. This is a review of current evidence regarding the relationship of aging with vascular senescence and CD. A deeper understanding of these mechanisms can contribute to the production of efficient prevention methods and targeted therapeutic strategies.
Identifiants
pubmed: 32582337
doi: 10.1155/2020/8601762
pmc: PMC7306882
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
8601762Informations de copyright
Copyright © 2020 Eleni Sertedaki et al.
Déclaration de conflit d'intérêts
The authors declare that no conflicts of interest exist.
Références
Free Radic Biol Med. 2013 Dec;65:380-401
pubmed: 23851032
Am J Pathol. 2007 Jan;170(1):388-98
pubmed: 17200210
Nature. 2012 Feb 22;483(7388):218-21
pubmed: 22367546
J Nutr Biochem. 2012 Nov;23(11):1410-6
pubmed: 22284404
J Gerontol A Biol Sci Med Sci. 2008 Feb;63(2):200-3
pubmed: 18314458
Am J Physiol Heart Circ Physiol. 2014 Aug 15;307(4):H533-41
pubmed: 24973384
FASEB J. 2003 Jun;17(9):1183-5
pubmed: 12709402
Oncogene. 2005 Jun 30;24(28):4486-95
pubmed: 15856023
Nucleic Acids Res. 2012 Sep;40(16):8048-58
pubmed: 22684508
JAMA. 2004 Apr 14;291(14):1730-7
pubmed: 15082700
Pharmacol Ther. 2012 Feb;133(2):159-76
pubmed: 22079549
Atherosclerosis. 2008 Jan;196(1):298-305
pubmed: 17118371
Circulation. 2012 Dec 18;126(25):2951-61
pubmed: 23159554
Antioxid Redox Signal. 2015 Dec 20;23(18):1389-409
pubmed: 26054376
Int J Mol Sci. 2015 Jul 13;16(7):15918-53
pubmed: 26184181
J Gerontol A Biol Sci Med Sci. 2010 Oct;65(10):1028-41
pubmed: 20576649
J Intern Med. 2000 Jun;247(6):679-88
pubmed: 10886490
J Nucl Med. 2011 Apr;52(4):497-500
pubmed: 21421716
J Physiol. 2007 Feb 15;579(Pt 1):227-36
pubmed: 17138603
Cell Death Dis. 2010;1:e10
pubmed: 21364612
Hypertension. 2007 Jul;50(1):219-27
pubmed: 17452499
Cell Res. 2013 Feb;23(2):274-89
pubmed: 23247627
Cell. 2013 Jun 6;153(6):1194-217
pubmed: 23746838
J Intern Med. 2017 May;281(5):471-482
pubmed: 28345303
Exp Gerontol. 2014 Apr;52:9-17
pubmed: 24463049
Br J Pharmacol. 2000 Sep;131(2):303-11
pubmed: 10991924
J Gerontol A Biol Sci Med Sci. 2006 Mar;61(3):211-7
pubmed: 16567369
Nat Rev Immunol. 2008 Oct;8(10):802-15
pubmed: 18825131
Trends Cell Biol. 2018 Jun;28(6):436-453
pubmed: 29477613
Circ Res. 2000 Mar 17;86(5):494-501
pubmed: 10720409
EMBO J. 2004 Jun 16;23(12):2369-80
pubmed: 15152190
Nat Rev Mol Cell Biol. 2013 Aug;14(8):475-88
pubmed: 23800994
Exp Gerontol. 2013 Nov;48(11):1329-37
pubmed: 23948180
Acta Pharmacol Sin. 2008 Feb;29(2):185-92
pubmed: 18215347
Cardiovasc Res. 2005 May 1;66(2):286-94
pubmed: 15820197
J Gerontol A Biol Sci Med Sci. 2015 May;70(5):554-65
pubmed: 24821105
J Physiol. 2010 Oct 15;588(Pt 20):3971-82
pubmed: 20807791
Atherosclerosis. 2015 Jan;238(1):147-52
pubmed: 25485738
Physiology (Bethesda). 2014 Jul;29(4):250-64
pubmed: 24985329
Invest Ophthalmol Vis Sci. 2014 May 27;55(6):3986-94
pubmed: 24867582
Kidney Int. 2015 Oct;88(4):711-21
pubmed: 26061549
Nutr Metab Cardiovasc Dis. 2008 Jun;18(5):349-56
pubmed: 17935958
Toxicol Pathol. 2007 Jun;35(4):495-516
pubmed: 17562483
FEBS Lett. 2008 Mar 5;582(5):543-8
pubmed: 18242175
J Am Med Dir Assoc. 2013 Dec;14(12):877-82
pubmed: 23792036
Acta Pharmacol Sin. 2010 Oct;31(10):1324-8
pubmed: 20835265
Hypertension. 2016 Jan;67(1):14-9
pubmed: 26553230
Ageing Res Rev. 2014 Sep;17:68-78
pubmed: 24681293
J Physiol. 2011 Sep 15;589(Pt 18):4545-54
pubmed: 21746786
Aging Cell. 2016 Oct;15(5):973-7
pubmed: 26864908
J Am Coll Cardiol. 2005 Nov 1;46(9):1753-60
pubmed: 16256881
Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H1025-32
pubmed: 21622824
J Hypertens. 2005 Sep;23(9):1717-24
pubmed: 16093917
J Physiol Biochem. 2007 Sep;63(3):239-47
pubmed: 18309780
Hypertens Res. 2018 Sep;41(9):748-755
pubmed: 29968848
J Cell Physiol. 2006 Jul;208(1):229-37
pubmed: 16575906
Endocr Metab Immune Disord Drug Targets. 2012 Dec;12(4):351-60
pubmed: 23061409
Cancer Res. 2017 Aug 15;77(16):4434-4447
pubmed: 28655790
Pharm Res. 2004 Apr;21(4):661-70
pubmed: 15139523
Age (Dordr). 2013 Aug;35(4):1157-72
pubmed: 22692818
PLoS One. 2010 May 20;5(5):e10724
pubmed: 20505758
J Exp Med. 2000 Dec 18;192(12):1731-44
pubmed: 11120770
J Gerontol A Biol Sci Med Sci. 2011 Aug;66(8):866-75
pubmed: 21622983
Aging (Albany NY). 2009 Apr;1(4):402-11
pubmed: 20148189
Am J Physiol Heart Circ Physiol. 2013 Nov 15;305(10):H1428-39
pubmed: 23997094
J Physiol. 2008 Nov 15;586(22):5295-304
pubmed: 18818246
Biomed Res Int. 2014;2014:615312
pubmed: 25143940
Sci Signal. 2014 Nov 11;7(351):ra106
pubmed: 25389371
J Hypertens. 2011 Oct;29(10):1847-53
pubmed: 21799443
Clin Sci (Lond). 2015 Jan;128(2):69-79
pubmed: 25236971
J Physiol. 2016 Apr 15;594(8):2125-46
pubmed: 26435167
Ageing Res Rev. 2010 Nov;9 Suppl 1:S59-66
pubmed: 20708718
Microcirculation. 2019 Feb;26(2):e12487
pubmed: 29924435
J Gerontol A Biol Sci Med Sci. 2015 Nov;70(11):1304-11
pubmed: 25352462
Aging Cell. 2008 Dec;7(6):805-12
pubmed: 18782346
Biochem Biophys Res Commun. 2012 Mar 9;419(2):381-7
pubmed: 22349511
Trends Endocrinol Metab. 2014 Mar;25(3):138-45
pubmed: 24388149
Drugs Aging. 2003;20(7):527-50
pubmed: 12749750
Physiol Rep. 2013 Nov;1(6):e00149
pubmed: 24400151
J Physiol. 2012 Jul 15;590(14):3305-16
pubmed: 22570377
J Appl Physiol (1985). 2008 Oct;105(4):1333-41
pubmed: 18599677
Lab Invest. 2005 Apr;85(4):502-11
pubmed: 15711569
Cardiovasc Pathol. 2005 May-Jun;14(3):126-34
pubmed: 15914297
Circ Res. 2000 Nov 10;87(10):840-4
pubmed: 11073878
Circ Res. 2011 Oct 28;109(10):1115-9
pubmed: 21903938
Circ Res. 2009 Feb 27;104(4):496-505
pubmed: 19131647
Front Genet. 2013 Jun 26;4:121
pubmed: 23805154
Circulation. 2007 Mar 13;115(10):1285-95
pubmed: 17353456
J Clin Invest. 2012 Jul;122(7):2601-12
pubmed: 22706308
Circulation. 2012 Jul 24;126(4):468-78
pubmed: 22705887
Mech Ageing Dev. 2005 Apr;126(4):467-73
pubmed: 15722105
Int J Mol Sci. 2014 Jun 25;15(7):11324-49
pubmed: 24968272
Hypertension. 2002 Apr;39(4):865-73
pubmed: 11967241
PLoS One. 2008 Mar 12;3(3):e1759
pubmed: 18335035
Curr Top Dev Biol. 2007;79:99-155
pubmed: 17498549
Aging (Albany NY). 2016 May;8(5):1064-82
pubmed: 27249230
Cardiovasc Res. 2018 Mar 15;114(4):513-528
pubmed: 29514201
Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3722-7
pubmed: 25775529
Antioxid Redox Signal. 2010 Dec 1;13(11):1649-63
pubmed: 20367496
Cardiovasc Res. 2013 Mar 1;97(3):571-9
pubmed: 23201774
Antioxid Redox Signal. 2014 Jul 1;21(1):86-102
pubmed: 24359220
Methods Mol Biol. 2013;965:165-73
pubmed: 23296657
Pol Arch Med Wewn. 2011 Oct;121(10):361-6
pubmed: 21946298
Ann Med. 2016 Nov;48(7):541-551
pubmed: 27595161
Atherosclerosis. 2016 Aug;251:63-69
pubmed: 27266823
Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):e108-e114
pubmed: 28835487
Am J Physiol Heart Circ Physiol. 2009 Jun;296(6):H1920-5
pubmed: 19376805
Atherosclerosis. 2011 May;216(1):212-6
pubmed: 21316055
Biochem Biophys Res Commun. 1993 Nov 15;196(3):1330-4
pubmed: 7504476
Cell Commun Signal. 2011 May 08;9:11
pubmed: 21549004
J Vasc Surg. 2015 Dec;62(6):1521-8
pubmed: 25499709
J Stroke Cerebrovasc Dis. 2018 Apr;27(4):865-870
pubmed: 29273464
Br J Pharmacol. 2011 Oct;164(3):894-912
pubmed: 21323907
J Nutr. 2015 Mar;145(3):532-40
pubmed: 25733469
Circulation. 2003 Jan 7;107(1):139-46
pubmed: 12515756
Int J Biol Sci. 2013 Jul 07;9(7):656-65
pubmed: 23904790
J Appl Physiol (1985). 2009 Oct;107(4):1249-57
pubmed: 19661445
Blood. 2005 Mar 15;105(6):2294-9
pubmed: 15572589
J Atheroscler Thromb. 2018 Jan 1;25(1):55-64
pubmed: 28179606
Atherosclerosis. 2014 Nov;237(1):177-82
pubmed: 25240113
Curr Opin Clin Nutr Metab Care. 2013 Jan;16(1):14-20
pubmed: 23132168
Circ Res. 2007 Sep 28;101(7):640-1
pubmed: 17901365
Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):623-32
pubmed: 22247254
Exp Clin Cardiol. 2002 Spring;7(1):40-53
pubmed: 19644578
Clin Cardiol. 2018 May;41(5):698-704
pubmed: 29752816
Clin Sci (Lond). 2009 Feb;116(3):219-30
pubmed: 19118493
Sci Transl Med. 2011 Dec 7;3(112):112ra122
pubmed: 22158860
J Clin Invest. 2001 Feb;107(3):255-64
pubmed: 11160146
Hypertension. 2008 Jun;51(6):1651-7
pubmed: 18426996
J Neurochem. 2012 Sep;122(6):1211-8
pubmed: 22784235
Mech Ageing Dev. 2013 Jul-Aug;134(7-8):314-20
pubmed: 23612189
PLoS One. 2016 Jan 25;11(1):e0147615
pubmed: 26808574
Nat Rev Endocrinol. 2018 Oct;14(10):576-590
pubmed: 30046148
Integr Comp Biol. 2010 Nov;50(5):829-43
pubmed: 21031035
Front Genet. 2014 Dec 10;5:422
pubmed: 25540650
Br J Pharmacol. 2005 Dec;146(8):1130-8
pubmed: 16231003
J Gerontol A Biol Sci Med Sci. 2006 Mar;61(3):232-44
pubmed: 16567371
Clin Sci (Lond). 2014 Dec;127(11):645-54
pubmed: 24947434
Ageing Res Rev. 2014 Nov;18:132-47
pubmed: 25311590
EMBO J. 2011 May 17;30(13):2520-31
pubmed: 21587205
Biomed Res Int. 2014;2014:902842
pubmed: 25162034
Maturitas. 2010 Sep;67(1):20-4
pubmed: 20452737
Nature. 2016 Feb 11;530(7589):184-9
pubmed: 26840489
Acta Cir Bras. 2016 Aug;31(8):564-8
pubmed: 27579885
Biochem Pharmacol. 2013 May 1;85(9):1288-96
pubmed: 23422569
Mech Ageing Dev. 2012 May;133(5):368-71
pubmed: 22484146
Cell. 2006 Jan 27;124(2):315-29
pubmed: 16439206
Recent Pat Cardiovasc Drug Discov. 2008 Nov;3(3):156-64
pubmed: 18991791
Geriatr Gerontol Int. 2015 Aug;15(8):1023-30
pubmed: 25312290
Ageing Res Rev. 2008 Apr;7(2):83-105
pubmed: 17964225
Herz. 2004 Dec;29(8):733-40
pubmed: 15599669
Circulation. 2006 Aug 15;114(7):623-9
pubmed: 16894037
J Intern Med. 2008 Feb;263(2):128-41
pubmed: 18226091
Am J Physiol Heart Circ Physiol. 2014 Dec 15;307(12):H1754-63
pubmed: 25326534