Metoprolol-Associated Central Nervous System Complications.
beta-blocker side effects
bizzare and vivid dreams
cns side effects
delirium
metoprolol side effects
metoprolol therapy
metoprolol toxicity
sleep disturbances
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
22 May 2020
22 May 2020
Historique:
entrez:
26
6
2020
pubmed:
26
6
2020
medline:
26
6
2020
Statut:
epublish
Résumé
Metoprolol is a common medication used by the elderly because it is affordable and has proven to decrease mortality in cardiovascular disease. Multiple studies have reported central nervous system (CNS) side effects associated with use of beta-blockers. The risk of beta-blocker CNS side effects is directly associated with the lipophilic property of the drug. We present the case of an 84-year-old male presented to the clinic complaining of increased confusion, fatigue, lightheadedness, nightmares, sleep disturbance, and gait problems for four weeks. The patient was evaluated for neurogenic and cardiogenic causes of his symptoms and both were ruled out. We believe that further review of his medical chart and medication reconciliation will lead us to the underlying cause of his symptoms. Despite being an effective treatment option, there are risks associated with beta-blocker therapy. The most common symptoms are psychiatric conditions, bizarre and vivid dreams, sleep disturbances, delirium, psychosis, and visual hallucinations. Elderly patients who are started on beta-blockers require close monitoring for any adverse neurological symptoms.
Identifiants
pubmed: 32582495
doi: 10.7759/cureus.8236
pmc: PMC7306637
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e8236Informations de copyright
Copyright © 2020, Shah et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Br Med J. 1978 May 6;1(6121):1182
pubmed: 638680
Psychosomatics. 2006 Nov-Dec;47(6):537-8
pubmed: 17116960
J Neuropsychiatry Clin Neurosci. 2016 Spring;28(2):143-6
pubmed: 26715033
Am J Alzheimers Dis Other Demen. 2007 Feb-Mar;22(1):57-61
pubmed: 17534003
J Med Case Rep. 2012 Feb 15;6:65
pubmed: 22336000
Pharmacol Ther. 1990;46(2):163-97
pubmed: 1969642
Int J Geriatr Psychiatry. 2010 Dec;25(12):1209-21
pubmed: 20033905
Eur J Clin Pharmacol. 1985;28 Suppl:69-72
pubmed: 4054193
Drug Des Devel Ther. 2017 Jan 25;11:305-312
pubmed: 28182127
Gen Hosp Psychiatry. 2015 Nov-Dec;37(6):620.e5-6
pubmed: 26184855