A case of advanced gastric cancer showing HER2 positivity after chemotherapy.
Biopsy
Epidermal growth factor receptor-2
Gastric cancer
Heterogeneity
Trastuzumab
Journal
International cancer conference journal
ISSN: 2192-3183
Titre abrégé: Int Cancer Conf J
Pays: Singapore
ID NLM: 101734231
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
27
12
2019
accepted:
19
03
2020
entrez:
26
6
2020
pubmed:
26
6
2020
medline:
26
6
2020
Statut:
epublish
Résumé
A 63-year-old man had advanced poorly differentiated gastric adenocarcinoma with para-aortic lymph node metastases. No HER2 expression was observed in four endoscopic biopsies from the primary tumor. Tumors shrunk after S-1 with cisplatin treatment, and he underwent simple gastrectomy due to stenosis. Interestingly, HER2 diffusely overexpressed in the resected surgical specimen. His disease was stable with trastuzumab-containing therapy for 6.4 months. This case may suggest a selection of HER2-positive cells that were insensitive to the chemotherapy, and further study is needed for the change of intratumoral HER2 heterogeneity after chemotherapy.
Identifiants
pubmed: 32582513
doi: 10.1007/s13691-020-00412-8
pii: 412
pmc: PMC7297895
doi:
Types de publication
Case Reports
Langues
eng
Pagination
112-115Informations de copyright
© The Japan Society of Clinical Oncology 2020.
Déclaration de conflit d'intérêts
Conflict of interestIH received honorarium and research funding from Chugai and Taiho Pharma.
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