Genetic Tracing of Clonal Expansion and Progression of Pancreatic Ductal Adenocarcinoma: A Case Report and Multi-Region Sequencing Analysis.
KRAS
clonal evolution
multi-region sequencing
pancreatic cancer
premalignant field defect
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2020
2020
Historique:
received:
29
11
2019
accepted:
16
04
2020
entrez:
26
6
2020
pubmed:
26
6
2020
medline:
26
6
2020
Statut:
epublish
Résumé
Pancreatobiliary tumors frequently contain multiple malignant and precancerous lesions; however, the origin of the driver mutations and the mechanisms that underlie the generation of distinct clones within an organ field remain unclear. Herein, we describe a 76-year-old male suffering from moderately differentiated adenocarcinomas of the pancreas that primarily involved the distal bile duct and multiple "dispersing" invasive lesions in the pancreatic head. The patient underwent pylorus-preserving pancreaticoduodenectomy with superior mesenteric vein resection, and targeted sequencing of 18 genes associated with pancreatic tumorigenesis and immunohistochemical analysis of RNF43 and ARID1A were performed on each tumor compartment, including the invasive and non-invasive areas. Multi-region sequencing revealed shared
Identifiants
pubmed: 32582528
doi: 10.3389/fonc.2020.00728
pmc: PMC7280449
doi:
Types de publication
Case Reports
Langues
eng
Pagination
728Informations de copyright
Copyright © 2020 Tachibana, Mizukami, Ono, Sugiyama, Okada, Kitazaki, Sasajima, Tominaga, Sakamoto, Kimura, Omori, Furukawa, Kimura, Tanaka, Nagashima, Karasaki, Ohta and Okumura.
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