Identification of RT-PCR-Negative Asymptomatic COVID-19 Patients via Serological Testing.
COVID-19
SARS-CoV-2
asymptomatic
reverse transcription polymerase chain reaction
serological test
Journal
Frontiers in public health
ISSN: 2296-2565
Titre abrégé: Front Public Health
Pays: Switzerland
ID NLM: 101616579
Informations de publication
Date de publication:
2020
2020
Historique:
received:
25
03
2020
accepted:
25
05
2020
entrez:
26
6
2020
pubmed:
26
6
2020
medline:
26
6
2020
Statut:
epublish
Résumé
Asymptomatic individuals with coronavirus disease (COVID-19) have been identified via nucleic acid testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); however, the epidemiologic characteristics and viral shedding pattern of asymptomatic patients remain largely unknown. In this study, serological testing was applied when identifying nine asymptomatic cases of COVID-19 who showed persistent negative RT-PCR test results for SARS-CoV-2 nucleic acid and no symptoms of COVID-19. Two asymptomatic cases were presumed to be index patients who had cleared the virus when their close contacts developed symptoms of COVID-19. Three of the asymptomatic cases were local individuals who spontaneously recovered before their presumed index patients developed symptoms of COVID-19. This report presents the epidemiologic and clinical characteristics of asymptomatic individuals with SARS-CoV-2 infection that were undetected on RT-PCR tests in previous epidemiologic investigations probably due to the transient viral shedding duration.
Identifiants
pubmed: 32582617
doi: 10.3389/fpubh.2020.00267
pmc: PMC7294962
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
267Informations de copyright
Copyright © 2020 Wu, Liu, Zhou, Qiu, Dai, Yang, Pan, Zhou and Wu.
Références
Lancet. 2020 Feb 15;395(10223):514-523
pubmed: 31986261
Int J Infect Dis. 2020 May;94:154-155
pubmed: 32179137
JAMA Intern Med. 2020 May 1;:
pubmed: 32356867
Nature. 2020 Mar 20;:
pubmed: 32203376
Sci China Life Sci. 2020 May;63(5):706-711
pubmed: 32146694
Zhonghua Liu Xing Bing Xue Za Zhi. 2020 Feb 10;41(2):145-151
pubmed: 32064853
J Microbiol Immunol Infect. 2020 Jun;53(3):404-412
pubmed: 32173241
Euro Surveill. 2020 Mar;25(10):
pubmed: 32183930
N Engl J Med. 2020 Mar 19;382(12):1177-1179
pubmed: 32074444
BMJ. 2020 Apr 2;369:m1375
pubmed: 32241884
J Autoimmun. 2020 May;109:102433
pubmed: 32113704
Clin Imaging. 2020 Jul;63:7-9
pubmed: 32120312
Nat Med. 2020 May;26(5):672-675
pubmed: 32296168
JAMA. 2020 Feb 21;:
pubmed: 32083643
Am J Obstet Gynecol MFM. 2020 Apr 9;:100118
pubmed: 32292903