Challenges in Abdominal Organ Transplantation During the COVID-19 Pandemic.

coronavirus immunosuppression kidney transplantation liver transplantation super-spreading events

Journal

Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047

Informations de publication

Date de publication:
2020
Historique:
received: 31 03 2020
accepted: 22 05 2020
entrez: 26 6 2020
pubmed: 26 6 2020
medline: 26 6 2020
Statut: epublish

Résumé

As the coronavirus disease 2019 (COVID-19) outbreak has rapidly evolved into a global pandemic, abdominal organ transplantation programs are currently facing multiple challenges. Transplant candidates and recipients are considered high-risk populations for severe disease and death due to COVID-19 as a result of their numerous underlying comorbidities, advanced age and impaired immune function. Emerging reports of atypical and delayed clinical presentations in these patients generate further concerns for widespread disease transmission to medical personnel and the community. The striking similarities between COVID-19 and other outbreaks that took place over the past two decades, like Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome, highlight the severity of the situation and dictate that extra measures should be taken by the transplant programs to avoid adverse outcomes. Transplant organizations are currently calling for strict screening and isolation protocols to be established in all transplant programs, for both organ donors and recipients. As the situation escalates, more radical measures might be necessary, including a temporary hold on non-urgent transplantations, resulting in serious ethical dilemmas between the survival of these patients and the safety of the community. Further data about these special populations could result in more individualized guidelines for abdominal organ transplantation in the era of COVID-19.

Identifiants

pubmed: 32582741
doi: 10.3389/fmed.2020.00287
pmc: PMC7287204
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

287

Informations de copyright

Copyright © 2020 Esagian, Ziogas, Giannis, Hayat, Elias and Tsoulfas.

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Auteurs

Stepan M Esagian (SM)

Surgery Working Group, Society of Junior Doctors, Athens, Greece.

Ioannis A Ziogas (IA)

Surgery Working Group, Society of Junior Doctors, Athens, Greece.
Department of Surgery, Division of Hepatobiliary Surgery and Liver Transplantation, Vanderbilt University Medical Center, Nashville, TN, United States.

Dimitrios Giannis (D)

Surgery Working Group, Society of Junior Doctors, Athens, Greece.
Institute of Health Innovations and Outcomes Research, The Feinstein Institute for Medical Research, Manhasset, NY, United States.

Muhammad H Hayat (MH)

Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, TN, United States.

Nahel Elias (N)

Department of Surgery, Transplantation Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.

Georgios Tsoulfas (G)

First Department of Surgery, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Classifications MeSH