Ancient genomes reveal complex patterns of population movement, interaction, and replacement in sub-Saharan Africa.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
06
08
2019
accepted:
15
04
2020
entrez:
26
6
2020
pubmed:
26
6
2020
medline:
26
6
2020
Statut:
epublish
Résumé
Africa hosts the greatest human genetic diversity globally, but legacies of ancient population interactions and dispersals across the continent remain understudied. Here, we report genome-wide data from 20 ancient sub-Saharan African individuals, including the first reported ancient DNA from the DRC, Uganda, and Botswana. These data demonstrate the contraction of diverse, once contiguous hunter-gatherer populations, and suggest the resistance to interaction with incoming pastoralists of delayed-return foragers in aquatic environments. We refine models for the spread of food producers into eastern and southern Africa, demonstrating more complex trajectories of admixture than previously suggested. In Botswana, we show that Bantu ancestry post-dates admixture between pastoralists and foragers, suggesting an earlier spread of pastoralism than farming to southern Africa. Our findings demonstrate how processes of migration and admixture have markedly reshaped the genetic map of sub-Saharan Africa in the past few millennia and highlight the utility of combined archaeological and archaeogenetic approaches.
Identifiants
pubmed: 32582847
doi: 10.1126/sciadv.aaz0183
pii: aaz0183
pmc: PMC7292641
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
eaaz0183Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).
Références
Bioinformatics. 2009 Jul 15;25(14):1754-60
pubmed: 19451168
Curr Biol. 2013 Apr 8;23(7):553-559
pubmed: 23523248
Science. 2019 Jul 5;365(6448):
pubmed: 31147405
BMC Bioinformatics. 2014 Nov 25;15:356
pubmed: 25420514
Am J Phys Anthropol. 2002 Nov;119(3):231-9
pubmed: 12365035
PLoS One. 2018 Apr 23;13(4):e0195491
pubmed: 29684051
J Infect Dis. 2017 Jul 1;216(1):45-54
pubmed: 28541483
PLoS One. 2019 May 8;14(5):e0215573
pubmed: 31067220
Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15758-63
pubmed: 24019490
Science. 2018 May 4;360(6388):548-552
pubmed: 29545507
Nature. 2014 Sep 18;513(7518):409-13
pubmed: 25230663
Science. 2009 May 22;324(5930):1035-44
pubmed: 19407144
BMC Res Notes. 2016 Feb 12;9:88
pubmed: 26868221
Genome Biol. 2016 Mar 31;17:60
pubmed: 27036623
PLoS Genet. 2012 Jan;8(1):e1002397
pubmed: 22253600
Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6774-6779
pubmed: 29895688
PLoS One. 2015 Jun 18;10(6):e0129102
pubmed: 26086078
Am J Phys Anthropol. 2001 May;115(1):24-37
pubmed: 11309747
Genome Res. 2015 Jun;25(6):918-25
pubmed: 25883319
Curr Biol. 2014 Apr 14;24(8):875-9
pubmed: 24704073
Nature. 2015 Jun 11;522(7555):207-11
pubmed: 25731166
Nature. 2018 Sep;561(7723):387-390
pubmed: 30158702
Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10693-8
pubmed: 18678889
Am J Phys Anthropol. 2009 Feb;138(2):164-76
pubmed: 18711740
Nature. 2016 Oct 13;538(7624):201-206
pubmed: 27654912
Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2632-7
pubmed: 24550290
Nat Commun. 2018 Aug 20;9(1):3336
pubmed: 30127404
Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2682-7
pubmed: 25730861
Bioinformatics. 2012 Jun 15;28(12):1647-9
pubmed: 22543367
Genetics. 2012 Nov;192(3):1065-93
pubmed: 22960212
Science. 2017 Nov 3;358(6363):652-655
pubmed: 28971970
Electrophoresis. 2009 Nov;30(21):3657-64
pubmed: 19810027
Science. 2019 Sep 6;365(6457):
pubmed: 31488661
Genome Biol. 2019 Apr 26;20(1):82
pubmed: 31023338
Philos Trans R Soc Lond B Biol Sci. 2015 Jan 19;370(1660):20130624
pubmed: 25487342
Nucleic Acids Res. 2016 Jul 8;44(W1):W58-63
pubmed: 27084951
PLoS Genet. 2006 Dec;2(12):e190
pubmed: 17194218
Science. 2015 Nov 13;350(6262):820-2
pubmed: 26449472
Cell. 2017 Sep 21;171(1):59-71.e21
pubmed: 28938123
Genome Res. 2009 Sep;19(9):1655-64
pubmed: 19648217
Am J Phys Anthropol. 1970 Nov;33(3):313-23
pubmed: 5490179
Nat Commun. 2012;3:1143
pubmed: 23072811
Nature. 2016 Aug 25;536(7617):419-24
pubmed: 27459054
Hum Mutat. 2013 Sep;34(9):1189-94
pubmed: 23696374
Am J Phys Anthropol. 2018 Nov;167(3):656-671
pubmed: 30192370
Nature. 2015 Aug 13;524(7564):216-9
pubmed: 26098372
Curr Biol. 2014 Apr 14;24(8):852-8
pubmed: 24704072
Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):8942-8947
pubmed: 30127016
Mol Biol Evol. 2007 Oct;24(10):2180-95
pubmed: 17656633
Sci Adv. 2019 Jul 03;5(7):eaax0061
pubmed: 31281897
Genome Biol. 2015 Oct 12;16:224
pubmed: 26458810
Science. 2006 Aug 11;313(5788):803-7
pubmed: 16857900