A highly potent lymphatic system-targeting nanoparticle cyclosporine prevents glomerulonephritis in mouse model of lupus.

Animals Cyclosporine / pharmacology Disease Models, Animal Glomerulonephritis / drug therapy Lupus Erythematosus, Systemic / drug therapy Lymphatic System Mice Mice, Inbred MRL lpr Nanoparticles

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
06 2020
Historique:
received: 20 02 2020
accepted: 29 04 2020
entrez: 26 6 2020
pubmed: 26 6 2020
medline: 12 4 2022
Statut: epublish

Résumé

Cyclosporine A (CsA) is a powerful immunosuppressant, but it is an ineffective stand-alone treatment for systemic lupus erythematosus (SLE) due to poor target tissue distribution and renal toxicity. We hypothesized that CD71 (transferrin receptor 1)-directed delivery of CsA to the lymphatic system would improve SLE outcomes in a murine model. We synthesized biodegradable, ligand-conjugated nanoparticles [P2Ns-gambogic acid (GA)] targeting CD71. GA conjugation substantially increased nanoparticle association with CD3

Identifiants

DOI: 10.1126/sciadv.abb3900 PMID: 32582860 PMC: PMC7292630
pubmed: 32582860
doi: 10.1126/sciadv.abb3900
pii: abb3900
pmc: PMC7292630
doi:

Substances chimiques

Cyclosporine 83HN0GTJ6D

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabb3900

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).

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Auteurs

Raghu Ganugula (R)

Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M University, College Station, TX, USA.
ORCID: 0000-0003-0262-5170

Meenakshi Arora (M)

Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M University, College Station, TX, USA.
ORCID: 0000-0003-3809-3153

Dianxiong Zou (D)

Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M University, College Station, TX, USA.
ORCID: 0000-0003-2534-1357

Sandeep K Agarwal (SK)

Section of Immunology, Allergy and Rheumatology, Department of Medicine, Biology of Inflammation Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA.

Chandra Mohan (C)

Department of Biomedical Engineering, University of Houston, Houston, TX, USA.
ORCID: 0000-0001-7896-5740

M N V Ravi Kumar (MNVR)

Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M University, College Station, TX, USA.
Section of Immunology, Allergy and Rheumatology, Department of Medicine, Biology of Inflammation Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA.
Department of Biomedical Engineering, University of Houston, Houston, TX, USA.
ORCID: 0000-0001-5606-401X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › A highly potent lymphatic system-targeting...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Peptides cycliques › Cyclosporines › Ciclosporine › A highly potent lymphatic system-targeting...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › A highly potent lymphatic system-targeting...
questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Maladies du rein › Néphrite › Glomérulonéphrite › A highly potent lymphatic system-targeting...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Lupus érythémateux disséminé › A highly potent lymphatic system-targeting...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › A highly potent lymphatic system-targeting...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A highly potent lymphatic system-targeting...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée MRL lpr › A highly potent lymphatic system-targeting...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › A highly potent lymphatic system-targeting...