Bmi deficiency causes oxidative stress and intervertebral disc degeneration which can be alleviated by antioxidant treatment.

Acetylcysteine / pharmacology Aggrecans / metabolism Animals Antioxidants / physiology Apoptosis / drug effects Collagen / metabolism Interleukin-1beta / metabolism Intervertebral Disc / drug effects Intervertebral Disc Degeneration / drug therapy Mice Organ Culture Techniques / methods Oxidative Stress / drug effects Polycomb Repressive Complex 1 / deficiency Proto-Oncogene Proteins / deficiency Superoxide Dismutase / metabolism Tumor Necrosis Factor-alpha / metabolism
Bmi-1 N-acetylcysteine cell apoptosis intervertebral disc degeneration oxidative stress

Journal

Journal of cellular and molecular medicine
ISSN: 1582-4934
Titre abrégé: J Cell Mol Med
Pays: England
ID NLM: 101083777

Informations de publication

Date de publication:
08 2020
Historique:
received: 13 02 2020
revised: 07 05 2020
accepted: 02 06 2020
pubmed: 26 6 2020
medline: 7 5 2021
entrez: 26 6 2020
Statut: ppublish

Résumé

The transcriptional repressor Bmi-1 is involved in cell-cycle regulation and cell senescence, the deficiency of which has been shown to cause oxidative stress. This study investigated whether Bmi-1 deficiency plays a role in promoting disc degeneration and the effect of treatment with antioxidant N-acetylcysteine (NAC) on intervertebral disc degeneration. Bmi-1

Identifiants

DOI: 10.1111/jcmm.15528 PMID: 32583517 PMC: PMC7417700
pubmed: 32583517
doi: 10.1111/jcmm.15528
pmc: PMC7417700
doi:

Substances chimiques

Aggrecans 0
Antioxidants 0
Bmi1 protein, mouse 0
Interleukin-1beta 0
Proto-Oncogene Proteins 0
Tumor Necrosis Factor-alpha 0
Collagen 9007-34-5
Superoxide Dismutase EC 1.15.1.1
superoxide dismutase 2 EC 1.15.1.1
Polycomb Repressive Complex 1 EC 2.3.2.27
Acetylcysteine WYQ7N0BPYC

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

8950-8961

Informations de copyright

© 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.

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Auteurs

Qunhu Zhang (Q)

Department of Orthopedics, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Department of Orthopaedics, Suqian First Hospital, Suqian, Jiangsu, China.

Jie Li (J)

Department of Orthopaedics, Xuzhou Central Hospital, Xuzhou Clinical College of Nanjing Medical University, The Affiliated Xuzhou Hospital of Southeast University, Xuzhou, Jiangsu, China.

You Li (Y)

Department of Orthopedics, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

Hui Che (H)

Department of Orthopedics, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

Ying Chen (Y)

Department of Orthopedics, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

Jianghui Dong (J)

Department of Hand Surgery, Department of Plastic Reconstructive Surgery, Ningbo No. 6 Hospital, Ningbo, Zhejiang, China.
UniSA Clinical and Health Sciences and UniSA Cancer Research Institute, University of South Australia, Adelaide, SA, Australia.
ORCID: 0000-0003-3961-1688

Cory J Xian (CJ)

UniSA Clinical and Health Sciences and UniSA Cancer Research Institute, University of South Australia, Adelaide, SA, Australia.
ORCID: 0000-0002-8467-2845

Dengshun Miao (D)

State Key Laboratory of Reproductive Medicine, The Research Center for Bone and Stem Cells, Department of Anatomy, Histology and Embryology, Nanjing Medical University, Nanjing, Jiangsu, China.

Liping Wang (L)

Department of Hand Surgery, Department of Plastic Reconstructive Surgery, Ningbo No. 6 Hospital, Ningbo, Zhejiang, China.
UniSA Clinical and Health Sciences and UniSA Cancer Research Institute, University of South Australia, Adelaide, SA, Australia.
ORCID: 0000-0001-9355-1167

Yongxin Ren (Y)

Department of Orthopedics, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés soufrés › Cystéine › Acétylcystéine › Bmi deficiency causes oxidative stress and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Protéines de la matrice extracellulaire › Agrécanes › Bmi deficiency causes oxidative stress and...
questionsmedicales.fr › Eucaryotes › Animaux › Bmi deficiency causes oxidative stress and...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Bmi deficiency causes oxidative stress and...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Bmi deficiency causes oxidative stress and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Protéines de la matrice extracellulaire › Collagène › Bmi deficiency causes oxidative stress and...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Monokines › Interleukine-1 › Interleukine-1 bêta › Bmi deficiency causes oxidative stress and...
questionsmedicales.fr › Tissus › Tissu conjonctif › Cartilage › Fibrocartilage › Disque intervertébral › Bmi deficiency causes oxidative stress and...
questionsmedicales.fr › Maladies ostéomusculaires › Maladies osseuses › Maladies du rachis › Dégénérescence de disque intervertébral › Bmi deficiency causes oxidative stress and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Bmi deficiency causes oxidative stress and...
questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › Techniques de culture › Techniques de culture d'organes › Bmi deficiency causes oxidative stress and...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Bmi deficiency causes oxidative stress and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines de répression › Protéines du groupe Polycomb › Complexe répresseur Polycomb-1 › Bmi deficiency causes oxidative stress and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Bmi deficiency causes oxidative stress and...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Superoxide dismutase › Bmi deficiency causes oxidative stress and...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Facteurs de nécrose tumorale › Facteur de nécrose tumorale alpha › Bmi deficiency causes oxidative stress and...