Microbial Products and Metabolites Contributing to Alcohol-Related Liver Disease.
alcoholic liver disease
microbiome
mycobiome
Journal
Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
17
03
2020
revised:
01
06
2020
pubmed:
26
6
2020
medline:
30
10
2021
entrez:
26
6
2020
Statut:
ppublish
Résumé
As a serious public health concern, alcohol-related liver disease is associated with dysregulations in the intestinal barrier function and the gut microbiota. The liver and gut communicate via the gut-liver axis, through which microbial products and metabolites translocate to the liver. Here, the current knowledge of various microbial products and metabolites which contribute to the alcohol-related liver diseases, including bile acids, indole-3-acetic acid, butyrate, long-chain fatty acids, endotoxin, cytolysin, β-glucan, and candidalysin is reviewed. Some of these might serve as therapeutic targets for alcohol-related liver disease.
Identifiants
pubmed: 32583604
doi: 10.1002/mnfr.202000023
pmc: PMC7758187
mid: NIHMS1652738
doi:
Substances chimiques
Bile Acids and Salts
0
Butyrates
0
ECE1 protein, Candida albicans
0
Endotoxins
0
Fungal Proteins
0
Indoleacetic Acids
0
beta-Glucans
0
indoleacetic acid
6U1S09C61L
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2000023Subventions
Organisme : NIAAA NIH HHS
ID : R01 AA020703
Pays : United States
Organisme : BLRD VA
ID : I01 BX004594
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK120515
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA024726
Pays : United States
Organisme : NIAAA NIH HHS
ID : R37 AA020703
Pays : United States
Organisme : NIAAA NIH HHS
ID : U01 AA026939
Pays : United States
Informations de copyright
© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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