Microenvironmental pH modifying films for buccal delivery of saquinavir: Effects of organic acids on pH and drug release in vitro.
Buccal film
Saquinavir
UV/Vis imaging
pH modification
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
30 Jul 2020
30 Jul 2020
Historique:
received:
07
05
2020
revised:
17
06
2020
accepted:
19
06
2020
pubmed:
26
6
2020
medline:
4
3
2021
entrez:
26
6
2020
Statut:
ppublish
Résumé
Buccal delivery of saquinavir has the advantage to bypass the gastrointestinal enzymatic degradation and the hepatic first-pass metabolism. Saquinavir has a pH-dependent solubility and is poorly soluble in human saliva at the physiological pH. Decreasing microenvironmental pH (pH
Identifiants
pubmed: 32585177
pii: S0378-5173(20)30551-2
doi: 10.1016/j.ijpharm.2020.119567
pii:
doi:
Substances chimiques
Saquinavir
L3JE09KZ2F
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
119567Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.