Randomized, double-blind, placebo-controlled clinical trial studying the effects of Turmeric in combination with mefenamic acid in patients with primary dysmenorrhoea.
Anti-Inflammatory Agents, Non-Steroidal
/ therapeutic use
Curcuma
/ chemistry
Curcumin
/ therapeutic use
Double-Blind Method
Drug Therapy, Combination
/ methods
Dysmenorrhea
/ drug therapy
Female
Humans
Mefenamic Acid
/ therapeutic use
Phytotherapy
/ methods
Placebos
/ therapeutic use
Students
Young Adult
Mefenamic acid
Menstrual pain
Primary dysmenorrhea
Turmeric
Journal
Journal of gynecology obstetrics and human reproduction
ISSN: 2468-7847
Titre abrégé: J Gynecol Obstet Hum Reprod
Pays: France
ID NLM: 101701588
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
23
05
2019
revised:
07
06
2020
accepted:
12
06
2020
pubmed:
26
6
2020
medline:
29
10
2021
entrez:
26
6
2020
Statut:
ppublish
Résumé
Primary dysmenorrhea (PDM) is one of the common complaints in women. This study aimed to assess the effects of turmeric and mefenamic acid and a combination compared with placebo on PDM. This clinical trial was conducted on dormitory students with PDM. Subjects completed the visual analog scale (VAS) before randomization. One hundred twenty-eight patients, randomly assigned to one of following groups: Turmeric group (n=32), mefenamic acid group (n=32), turmeric and mefenamic acid group (n=32), and placebo group (n=32). Turmeric and mefenamic acid were administrated in 500mg and 250mg, respectively. Pain severity was assessed in the baseline and the end line by VAS. Statistical analysis was performed using SPSS software. The combination of turmeric and mefenamic acid, dramatically, alleviated pain in comparison to other groups. Our results illustrated that combination of turmeric and mefenamic acid would be better in pain alleviation in PDM.
Identifiants
pubmed: 32585392
pii: S2468-7847(20)30184-7
doi: 10.1016/j.jogoh.2020.101840
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents, Non-Steroidal
0
Placebos
0
Mefenamic Acid
367589PJ2C
Curcumin
IT942ZTH98
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
101840Informations de copyright
Copyright © 2020 Elsevier Masson SAS. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no conflict of interest.