Imunofan-RDKVYR Peptide-Stimulates Skin Cell Proliferation and Promotes Tissue Repair.
Albumins
/ metabolism
Animals
Basophils
/ drug effects
Cell Death
/ drug effects
Cell Line
Cell Proliferation
/ drug effects
Chemotaxis
/ drug effects
Cytokines
/ metabolism
DNA Methylation
/ drug effects
Ear
/ pathology
Fibroblasts
/ cytology
HaCaT Cells
/ cytology
Humans
Injections, Subcutaneous
Mice, Inbred BALB C
Mice, Inbred C57BL
Oligopeptides
/ blood
Protein Stability
/ drug effects
Skin
/ pathology
Stem Cells
/ cytology
Transcription, Genetic
/ drug effects
Wound Healing
adipose-derived stem cells
cell proliferation
ear pinna model
fibroblasts
immunological safety
imunofan
keratinocytes
peptides
transcriptomics
wound healing
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
23 Jun 2020
23 Jun 2020
Historique:
received:
20
05
2020
revised:
18
06
2020
accepted:
19
06
2020
entrez:
27
6
2020
pubmed:
27
6
2020
medline:
20
2
2021
Statut:
epublish
Résumé
Regeneration and wound healing are vital to tissue homeostasis and organism survival. One of the biggest challenges of today's science and medicine is finding methods and factors to stimulate these processes in the human body. Effective solutions to promote regenerative responses will accelerate advances in tissue engineering, regenerative medicine, transplantology, and a number of other clinical specialties. In this study, we assessed the potential efficacy of a synthetic hexapeptide, RDKVYR, for the stimulation of tissue repair and wound healing. The hexapeptide is marketed under the name "Imunofan" (IM) as an immunostimulant. IM displayed stability in aqueous solutions, while in plasma it was rapidly bound by albumins. Structural analyses demonstrated the conformational flexibility of the peptide. Tests in human fibroblast and keratinocyte cell lines showed that IM exerted a statistically significant (
Identifiants
pubmed: 32585846
pii: molecules25122884
doi: 10.3390/molecules25122884
pmc: PMC7355430
pii:
doi:
Substances chimiques
Albumins
0
Cytokines
0
Oligopeptides
0
thymohexin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Narodowe Centrum Badań i Rozwoju
ID : STRATEGMED1/235077/9/NCBR/2014
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