ROR1 Is Expressed in Diffuse Large B-Cell Lymphoma (DLBCL) and a Small Molecule Inhibitor of ROR1 (KAN0441571C) Induced Apoptosis of Lymphoma Cells.
DLBCL
ROR1
small molecules
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
23 Jun 2020
23 Jun 2020
Historique:
received:
14
05
2020
revised:
10
06
2020
accepted:
19
06
2020
entrez:
27
6
2020
pubmed:
27
6
2020
medline:
27
6
2020
Statut:
epublish
Résumé
The receptor tyrosine kinase ROR1 is absent in most normal adult tissues, but overexpressed in several malignancies. In this study, we explored clinical and functional inhibitory aspects of ROR1 in diffuse large B-cell lymphoma (DLBCL). ROR1 expression in tumor cells was more often observed in primary refractory DLBCL, Richter's syndrome and transformed follicular lymphoma than in relapsed and non-relapsed DLBCL patients (
Identifiants
pubmed: 32586008
pii: biomedicines8060170
doi: 10.3390/biomedicines8060170
pmc: PMC7344684
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : THE ÅKE OLSSON FOUNDATION
ID : 2017-00436; 2019-00396
Organisme : THE CANCER AND ALLERGY FOUNDATION
ID : 2016/5, 2017/63, 2018/63, 2019/189, 2020/258 (AÖ); 2017/64, 2018/140, 2019/194, 2020/260 (HM)
Organisme : THE CANCER SOCIETY IN STOCKHOLM
ID : 151313, 184203 (AÖ); 144142, 164122 (HM)
Organisme : THE SWEDISH CANCER SOCIETY
ID : CAN 2015/408, CAN 2018/499 (AÖ)
Organisme : AFA INSURANCE
ID : 130054 (AÖ)
Organisme : THE STOCKHOLM COUNTY COUNCIL
ID : 20150070, 20180030 (AÖ)
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