Metabolism of Soy Isoflavones by Intestinal Bacteria: Genome Analysis of an
Adlercreutzia equolifaciens
daidzein
equol
fecal microbiota
genistein
intestinal microorganisms
soy isoflavones
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
23 06 2020
23 06 2020
Historique:
received:
17
04
2020
revised:
05
06
2020
accepted:
20
06
2020
entrez:
27
6
2020
pubmed:
27
6
2020
medline:
13
4
2021
Statut:
epublish
Résumé
Isoflavones are transformed in the gut into more estrogen-like compounds or into inactive molecules. However, neither the intestinal microbes nor the pathways leading to the synthesis of isoflavone-derived metabolites are fully known. In the present work, 73 fecal isolates from three women with an equol-producing phenotype were considered to harbor equol-related genes by qPCR. After typing, 57 different strains of different taxa were tested for their ability to act on the isoflavones daidzein and genistein. Strains producing small to moderate amounts of dihydrodaidzein and/or
Identifiants
pubmed: 32586036
pii: biom10060950
doi: 10.3390/biom10060950
pmc: PMC7355428
pii:
doi:
Substances chimiques
Isoflavones
0
Equol
531-95-3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : AGL2014-57820-R
Pays : International
Organisme : Gobierno del Principado de Asturias
ID : IDI/2018/000114
Pays : International
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
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