Synergistic Evaluation of Ginger and Licorice Extracts in a Mouse Model of Colorectal Cancer.
Journal
Nutrition and cancer
ISSN: 1532-7914
Titre abrégé: Nutr Cancer
Pays: United States
ID NLM: 7905040
Informations de publication
Date de publication:
2021
2021
Historique:
pubmed:
27
6
2020
medline:
19
8
2021
entrez:
27
6
2020
Statut:
ppublish
Résumé
Herbal medicine can be used to overcome the side effects of conventional treatments. This study aimed to evaluate the anticancer activities of ginger and licorice extracts, as well as the synergistic effects of their combination. Ginger ethanolic extract (GEE) and licorice methanolic extract (LME) were isolated by a Soxhlet extractor. Next, the anti-proliferative activity of the extracts, apoptosis induction, tumor growth inhibition, and tumor-infiltrating T lymphocytes were investigated. The MTT (3-[4, 5-dimethylthiazol-2-yl]-2, five diphenyl tetrazolium bromide) assay showed that GEE and LME decreased the CT26 cell viability in a dose-dependent manner; however, the GEE + LME combination was more effective (
Identifiants
pubmed: 32586136
doi: 10.1080/01635581.2020.1784440
doi:
Substances chimiques
Plant Extracts
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM