Early Puberty and Telomere Length in Preadolescent Girls and Mothers.
Journal
The Journal of pediatrics
ISSN: 1097-6833
Titre abrégé: J Pediatr
Pays: United States
ID NLM: 0375410
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
06
09
2019
revised:
30
01
2020
accepted:
27
02
2020
entrez:
27
6
2020
pubmed:
27
6
2020
medline:
26
11
2020
Statut:
ppublish
Résumé
To test the association between early puberty and telomere length in preadolescent girls and mothers from a large representative sample of US females. We analyzed data from 1194 preadolescent girls and 2421 mothers from the Fragile Families and Child Wellbeing Study. Participants were from a population-based birth cohort (1998-2000) born in large US cities. Telomere length was assessed by quantitative polymerase chain reaction from saliva samples provided by preadolescent girls and mothers of preadolescent youth. Mothers completed a questionnaire about their child's pubertal development to determine concurrent Tanner stages and provided self-reports of her own age at menarche. Linear regression models were used to estimate the association between pubertal development (status and timing) and telomere length. Early pubertal timing but not pubertal status was associated with shorter telomere length in preadolescent girls (P < .01). Early age at menarche was associated with shorter telomere length in a sample of mothers of preadolescent youth (P < .05). Results provide evidence for the association between early puberty and shorter telomeres evidenced by associations in both preadolescent girls and mothers. Future research should address the limitations of this study by using longitudinal measurements of pubertal development assessed through medical examinations and repeated assessments of telomere length to capture telomere attrition.
Identifiants
pubmed: 32586523
pii: S0022-3476(20)30290-0
doi: 10.1016/j.jpeds.2020.02.075
pmc: PMC7405936
mid: NIHMS1600588
pii:
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
193-199.e5Subventions
Organisme : NICHD NIH HHS
ID : R01 HD036916
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD076592
Pays : United States
Organisme : NIMHD NIH HHS
ID : R01 MD011716
Pays : United States
Organisme : NICHD NIH HHS
ID : R25 HD074544
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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