Circumscribed choroidal haemangioma: Indocyanine green angiography features on scanning laser ophthalmoscopy versus traditional digital fundus photography.
Journal
Eye (London, England)
ISSN: 1476-5454
Titre abrégé: Eye (Lond)
Pays: England
ID NLM: 8703986
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
21
01
2020
accepted:
12
06
2020
revised:
11
06
2020
pubmed:
27
6
2020
medline:
6
7
2021
entrez:
27
6
2020
Statut:
ppublish
Résumé
Circumscribed choroidal haemangioma (CCH) has several characteristic clinical and angiographic features. We aimed to compare indocyanine green angiography (ICG) findings of CCH captured on a traditional digital camera system (DCS) to newer scanning laser ophthalmoscopy (SLO) platforms. A total of 35 patients over a 10-year period diagnosed with CCH using ICG were included (18 imaged with DCS and 17 with SLO). On early ICG frames, intrinsic vessels were apparent in two-thirds (12/18; 67%) of the DCS group compared with all of eyes in the SLO group (p = 0.020). In addition, at maximal hyperfluorescence, most eyes imaged with DCS had a feathery appearance (16/18; 89%) compared with those in the SLO group which all (17/17; 100%) displayed a granular appearance (p < 0.001). The presence of hot spots at maximal hyperfluorescence was also more common in the SLO group (12/17; 71%) versus the DCS group (0/18; 0%) (p < 0.001). Finally, intrinsic vessels and vascular loops could be identified throughout the entire duration of the ICG in 100% of the SLO cases (17/17) versus only 11% (2/18) of DCS cases (p < 0.001). The visualization of intrinsic vessels, vascular loops, and "hot spots" in CCH is significantly enhanced with SLO compared with DCS. Many characteristic mid-late angiographic findings of CCH are more optimally visualized on SLO which may negate the need for late frames (>30 min) without compromising diagnostic accuracy.
Sections du résumé
BACKGROUND AND OBJECTIVE
OBJECTIVE
Circumscribed choroidal haemangioma (CCH) has several characteristic clinical and angiographic features. We aimed to compare indocyanine green angiography (ICG) findings of CCH captured on a traditional digital camera system (DCS) to newer scanning laser ophthalmoscopy (SLO) platforms.
STUDY DESIGN/MATERIALS AND METHODS
METHODS
A total of 35 patients over a 10-year period diagnosed with CCH using ICG were included (18 imaged with DCS and 17 with SLO).
RESULTS
RESULTS
On early ICG frames, intrinsic vessels were apparent in two-thirds (12/18; 67%) of the DCS group compared with all of eyes in the SLO group (p = 0.020). In addition, at maximal hyperfluorescence, most eyes imaged with DCS had a feathery appearance (16/18; 89%) compared with those in the SLO group which all (17/17; 100%) displayed a granular appearance (p < 0.001). The presence of hot spots at maximal hyperfluorescence was also more common in the SLO group (12/17; 71%) versus the DCS group (0/18; 0%) (p < 0.001). Finally, intrinsic vessels and vascular loops could be identified throughout the entire duration of the ICG in 100% of the SLO cases (17/17) versus only 11% (2/18) of DCS cases (p < 0.001).
CONCLUSIONS
CONCLUSIONS
The visualization of intrinsic vessels, vascular loops, and "hot spots" in CCH is significantly enhanced with SLO compared with DCS. Many characteristic mid-late angiographic findings of CCH are more optimally visualized on SLO which may negate the need for late frames (>30 min) without compromising diagnostic accuracy.
Identifiants
pubmed: 32587385
doi: 10.1038/s41433-020-1044-4
pii: 10.1038/s41433-020-1044-4
pmc: PMC8115271
doi:
Substances chimiques
Indocyanine Green
IX6J1063HV
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1178-1186Références
Shields CL, Honavar SG, Shields JA, Cater J, Demirci H. Circumscribed choroidal hemangioma: clinical manifestations and factors predictive of visual outcome in 200 consecutive cases. Ophthalmology. 2001;108:2237–48.
doi: 10.1016/S0161-6420(01)00812-0
Krohn J, Rishi P, Froystein T, Singh AD. Circumscribed choroidal haemangioma: clinical and topographical features. Br J Ophthalmol. 2019;103:1448–52.
doi: 10.1136/bjophthalmol-2018-313388
Singh ADDB, Pe’er J. Clinical ophthalmic oncology. Philadelphia, PA: Saunders Elsevier; 2007.
Kim RS, Jain RR, Brown DM, Bretana ME, Kegley EN, Singer MA, et al. Elevated choroidal thickness and central serous chorioretinopathy in the fellow eyes of patients with circumscribed choroidal hemangioma. Ocul Oncol Pathol 2018;4:375–80.
doi: 10.1159/000486864
Sobol EK, Francis JH, Abramson DH, Freund KB, Spaide RF, Barbazetto I. Subfoveal choroidal thickness and vascular architecture in fellow eyes of patients with circumscribed choroidal hemangioma. Retina. 2020;40:758–64.
doi: 10.1097/IAE.0000000000002438
Verbeek AM, Koutentakis P, Deutman AF. Circumscribed choroidal hemangioma diagnosed by ultrasonography. A retrospective analysis of 40 cases. Int Ophthalmol. 1995;19:185–9.
doi: 10.1007/BF00133736
Rojanaporn D, Kaliki S, Ferenczy SR, Shields CL. Enhanced depth imaging optical coherence tomography of circumscribed choroidal hemangioma in 10 consecutive cases. Middle East Afr J Ophthalmol. 2015;22:192–7.
doi: 10.4103/0974-9233.150629
Shah SU, Kaliki S, Shields CL, Ferenczy SR, Harmon SA, Shields JA. Enhanced depth imaging optical coherence tomography of choroidal nevus in 104 cases. Ophthalmology. 2012;119:1066–72.
doi: 10.1016/j.ophtha.2011.11.001
Shields CL, Kaliki S, Rojanaporn D, Ferenczy SR, Shields JA. Enhanced depth imaging optical coherence tomography of small choroidal melanoma: comparison with choroidal nevus. Arch Ophthalmol. 2012;130:850–6.
doi: 10.1001/archophthalmol.2012.1135
Witkin AJ, Fischer DH, Shields CL, Reichstein D, Shields JA. Enhanced depth imaging spectral-domain optical coherence tomography of a subtle choroidal metastasis. Eye. 2012;26:1598–9.
doi: 10.1038/eye.2012.201
Arevalo JF, Shields CL, Shields JA, Hykin PG, De Potter P. Circumscribed choroidal hemangioma: characteristic features with indocyanine green videoangiography. Ophthalmology. 2000;107:344–50.
doi: 10.1016/S0161-6420(99)00051-2
Hassenstein A, Meyer CH. Clinical use and research applications of Heidelberg retinal angiography and spectral-domain optical coherence tomography - a review. Clin Exp Ophthalmol. 2009;37:130–43.
doi: 10.1111/j.1442-9071.2009.02017.x
Yannuzzi LA, Slakter JS, Sorenson JA, Guyer DR, Orlock DA. Digital indocyanine green videoangiography and choroidal neovascularization. Retina. 1992;12:191–223.
doi: 10.1097/00006982-199212030-00003
Yannuzzi LA. Indocyanine green angiography: a perspective on use in the clinical setting. Am J Ophthalmol. 2011;151:745–51, e741.
doi: 10.1016/j.ajo.2011.01.043
Yannuzzi LA, Wong DW, Sforzolini BS, Goldbaum M, Tang KC, Spaide RF, et al. Polypoidal choroidal vasculopathy and neovascularized age-related macular degeneration. Arch Ophthalmol. 1999;117:1503–10.
doi: 10.1001/archopht.117.11.1503
Rouvas AA, Papakostas TD, Ntouraki A, Douvali M, Vergados I, Ladas ID. Angiographic and OCT features of retinal angiomatous proliferation. Eye. 2010;24:1633–42.
doi: 10.1038/eye.2010.134
Inoue R, Sawa M, Tsujikawa M, Gomi F. Association between the efficacy of photodynamic therapy and indocyanine green angiography findings for central serous chorioretinopathy. Am J Ophthalmol. 2010;149:441–6, e441–2.
doi: 10.1016/j.ajo.2009.10.011
Yannuzzi LA, Slakter JS, Gross NE, Spaide RF, Costa D, Huang SJ, et al. Indocyanine green angiography-guided photodynamic therapy for treatment of chronic central serous chorioretinopathy: a pilot study. Retina. 2003;23:288–98.
doi: 10.1097/00006982-200306000-00002
Bouchenaki N, Cimino L, Auer C, Tao Tran V, Herbort CP. Assessment and classification of choroidal vasculitis in posterior uveitis using indocyanine green angiography. Klin Monbl Augenheilkd. 2002;219:243–9.
doi: 10.1055/s-2002-30661
Balasubramaniam SC, Pellegrini M, Staurenghi G, Pulido JS. Infrared imaging of circumscribed choroidal hemangiomas. Retina. 2017;37:1134–9.
doi: 10.1097/IAE.0000000000001317
Schalenbourg A, Piguet B, Zografos L. Indocyanine green angiographic findings in choroidal hemangiomas: a study of 75 cases. Ophthalmologica. 2000;214:246–52.
doi: 10.1159/000027499
Shields JA, Mashayekhi A, Ra S, Shields CL. Pseudomelanomas of the posterior uveal tract: the 2006 Taylor R. Smith Lecture. Retina. 2005;25:767–71.
doi: 10.1097/00006982-200509000-00013
Shields CL, Shields JA, De Potter P. Patterns of indocyanine green videoangiography of choroidal tumours. Br J Ophthalmol. 1995;79:237–45.
doi: 10.1136/bjo.79.3.237
Shiraki K, Moriwaki M, Yanagihara N, Kohno T, Miki T. Indocyanine green angiograms of choroidal nevi. comparison between confocal and nonconfocal scanning laser ophthalmoscope and fundus video camera. Jpn J Ophthalmol. 2001;45:368–74.
doi: 10.1016/S0021-5155(01)00362-8
Tan CS, Ting DS, Lim LW. Multicolor fundus imaging of polypoidal choroidal vasculopathy. Ophthalmol Retin. 2019;3:400–9.
doi: 10.1016/j.oret.2019.01.009
Campagnoli TR, Medina CA, Singh AD. Choroidal melanoma initially treated as hemangioma: diagnostic and therapeutic considerations. Retin Cases Brief Rep. 2016;10:175–82.
doi: 10.1097/ICB.0000000000000220
Al-Dahmash SA, Shields CL, Kaliki S, Johnson T, Shields JA. Enhanced depth imaging optical coherence tomography of choroidal metastasis in 14 eyes. Retina. 2014;34:1588–93.
doi: 10.1097/IAE.0000000000000131
Aronow ME, Portell CA, Sweetenham JW, Singh AD. Uveal lymphoma: clinical features, diagnostic studies, treatment selection, and outcomes. Ophthalmology. 2014;121:334–41.
doi: 10.1016/j.ophtha.2013.09.004
Shields CL, Manalac J, Das C, Saktanasate J, Shields JA. Review of spectral domain enhanced depth imaging optical coherence tomography of tumors of the choroid. Indian J Ophthalmol. 2015;63:117–21.
doi: 10.4103/0301-4738.154377
Witschel H, Font RL. Hemangioma of the choroid. A clinicopathologic study of 71 cases and a review of the literature. Surv Ophthalmol. 1976;20:415–31.
doi: 10.1016/0039-6257(76)90067-9
Slakter JS, Yannuzzi LA, Sorenson JA, Guyer DR, Ho AC, Orlock DA. A pilot study of indocyanine green videoangiography-guided laser photocoagulation of occult choroidal neovascularization in age-related macular degeneration. Arch Ophthalmol. 1994;112:465–72.
doi: 10.1001/archopht.1994.01090160041020
Shields CL, Dalvin LA, Lim LS, Chang M, Udyaver S, Mazloumi M, et al. Circumscribed choroidal hemangioma: visual outcome in the pre-photodynamic therapy era versus photodynamic therapy era in 458 cases. Ophthalmol Retina. 2019;4:100–10.
doi: 10.1016/j.oret.2019.08.004
Papastefanou VP, Plowman PN, Reich E, Pavlidou E, Restori M, Hungerford JL, et al. Analysis of long-term outcomes of radiotherapy and verteporfin photodynamic therapy for circumscribed choroidal hemangioma. Ophthalmol Retin. 2018;2:842–57.
doi: 10.1016/j.oret.2017.12.002