The Potentiality of Herbal Remedies in Primary Sclerosing Cholangitis: From
bioflavonoids
cholangiocytes
hepatic stellate cells
herbal
phytochemicals
primary sclerosing cholangitis
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2020
2020
Historique:
received:
22
01
2020
accepted:
19
05
2020
entrez:
27
6
2020
pubmed:
27
6
2020
medline:
27
6
2020
Statut:
epublish
Résumé
Primary sclerosing cholangitis is a complex pathological condition, characterized by chronic inflammation and fibrosis of the biliary epithelium. Without proper clinical management, progressive bile ducts and liver damage lead to cirrhosis and, ultimately, to liver failure. The known limited role of current drugs for treating this cholangiopathy has driven researchers to assess alternative therapeutic options. Some herbal remedies and their phytochemicals have shown anti-fibrotic properties in different experimental models of hepatic diseases and, occasionally, in clinical trials in primary sclerosing cholangitis patients; however their mechanism of action is not completely understood. This review briefly examines relevant studies focusing on the potential anti-fibrotic properties of
Identifiants
pubmed: 32587513
doi: 10.3389/fphar.2020.00813
pmc: PMC7298067
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
813Informations de copyright
Copyright © 2020 Ceccherini, Cecchettini, Morales and Rocchiccioli.
Références
Ann Gastroenterol. 2019 Mar-Apr;32(2):124-133
pubmed: 30837784
Hepatology. 2011 Nov;54(5):1842-52
pubmed: 21793028
EBioMedicine. 2015 Sep 30;2(10):1310-1
pubmed: 26629523
J Hepatol. 2017 Dec;67(6):1298-1323
pubmed: 28802875
J Hepatol. 2013 Mar;58(3):575-82
pubmed: 23085249
J Food Sci. 2018 Sep;83(9):2280-2287
pubmed: 30103275
Dig Dis Sci. 2003 Apr;48(4):824-9
pubmed: 12741479
Gastroenterology. 2013 Sep;145(3):521-36
pubmed: 23827861
Mol Med Rep. 2016 Feb;13(2):1717-24
pubmed: 26676408
Environ Toxicol Pharmacol. 2011 May;31(3):443-52
pubmed: 21787715
Clin Gastroenterol Hepatol. 2012 Apr;10(4):439-41
pubmed: 22094024
Autophagy. 2012 Jan;8(1):126-8
pubmed: 22082960
Biochem Pharmacol. 2012 Jan 1;83(1):6-15
pubmed: 21856292
Am J Physiol Gastrointest Liver Physiol. 2017 Aug 1;313(2):G102-G116
pubmed: 28526690
Dig Liver Dis. 2005 May;37(5):349-56
pubmed: 15843085
Curr Med Chem. 2012;19(28):4850-60
pubmed: 22709007
Hepatology. 2016 Apr;63(4):1381-3
pubmed: 26662111
J Sci Food Agric. 2012 May;92(7):1441-7
pubmed: 22102319
Nat Genet. 2017 Feb;49(2):269-273
pubmed: 27992413
Curr Pharm Des. 2017;23(7):1077-1097
pubmed: 27748194
Nat Rev Gastroenterol Hepatol. 2011 Feb;8(2):108-18
pubmed: 21293511
Am J Physiol Cell Physiol. 2013 Oct 15;305(8):C789-99
pubmed: 23903700
Expert Rev Gastroenterol Hepatol. 2019 Aug;13(8):723-729
pubmed: 31257956
Int J Nanomedicine. 2016 Jan 05;11:121-30
pubmed: 26792989
Expert Rev Gastroenterol Hepatol. 2018 Jun;12(6):575-584
pubmed: 29781738
Rev Physiol Biochem Pharmacol. 2018;175:71-102
pubmed: 29728869
Hepatology. 1999 Sep;30(3):761-9
pubmed: 10462383
Front Pharmacol. 2018 Jul 16;9:762
pubmed: 30061833
Comp Hepatol. 2004 Jan 14;3 Suppl 1:S7
pubmed: 14960159
J Tradit Complement Med. 2017 Nov 22;8(3):352-360
pubmed: 29992106
Gastroenterology. 2012 Apr;142(4):938-46
pubmed: 22240484
Am J Physiol Gastrointest Liver Physiol. 2003 Jul;285(1):G20-30
pubmed: 12660143
Biochim Biophys Acta. 2007 Jun;1770(6):989-96
pubmed: 17383825
J Med Food. 2016 Aug;19(8):789-97
pubmed: 27441792
Gastroenterol Hepatol (N Y). 2018 May;14(5):293-304
pubmed: 29991937
Front Immunol. 2017 Jun 01;8:635
pubmed: 28620387
Clin Res Hepatol Gastroenterol. 2015 Sep;39 Suppl 1:S24-8
pubmed: 26189984
Hepatology. 1997 Sep;26(3):643-9
pubmed: 9303494
Hepatology. 2015 Jan;61(1):382-92
pubmed: 24930574
Evid Based Complement Alternat Med. 2017;2017:5364010
pubmed: 28246540
J Gastroenterol Hepatol. 2012 Dec;27(12):1865-72
pubmed: 22989100
Lab Invest. 2008 Feb;88(2):112-23
pubmed: 18059363
Fundam Clin Pharmacol. 2017 Dec;31(6):610-624
pubmed: 28802065
Gastroenterology. 2007 May;132(5):1937-46
pubmed: 17484886
Molecules. 2013 Feb 06;18(2):2122-34
pubmed: 23389256
Hepatology. 2014 May;59(5):1932-43
pubmed: 24338559
Int Immunopharmacol. 2017 Jun;47:126-133
pubmed: 28391159
Pharmacogn Rev. 2016 Jul-Dec;10(20):84-89
pubmed: 28082789
Gastroenterology. 2004 Jul;127(1):261-74
pubmed: 15236191
Int J Mol Sci. 2019 Jun 01;20(11):
pubmed: 31159366
J Pharmacopuncture. 2018 Jun;21(2):90-97
pubmed: 30151309
Stem Cells Int. 2016;2016:2953727
pubmed: 26880950
Best Pract Res Clin Gastroenterol. 2017 Apr;31(2):187-198
pubmed: 28624107
J Clin Invest. 2015 May;125(5):1886-900
pubmed: 25822023
Free Radic Biol Med. 2012 May 1;52(9):1658-65
pubmed: 22343419
Cancers (Basel). 2019 Jul 25;11(8):
pubmed: 31349670
J Hepatol. 1998 Nov;29(5):760-71
pubmed: 9833914
Phytomedicine. 2012 Dec 15;20(1):40-6
pubmed: 23072776
Hepatology. 2011 Apr;53(4):1342-51
pubmed: 21480338
Am J Gastroenterol. 2004 Mar;99(3):523-6
pubmed: 15056096
J Hepatol. 1998 Sep;29(3):409-16
pubmed: 9764987
Gut. 2017 Nov;66(11):1873-1877
pubmed: 28733279
Sci Rep. 2020 Mar 31;10(1):5718
pubmed: 32235914
Curr Ther Res Clin Exp. 2008 Dec;69(6):488-502
pubmed: 24692823
J Clin Invest. 2008 Oct;118(10):3331-42
pubmed: 18802480
Molecules. 2017 Jan 24;22(2):
pubmed: 28125040
Altern Med Rev. 2009 Jun;14(2):141-53
pubmed: 19594223
Mol Pharmacol. 2008 Feb;73(2):399-409
pubmed: 18006644
Int J Mol Sci. 2012 Oct 22;13(10):13621-66
pubmed: 23202971
Int J Mol Sci. 2018 Oct 01;19(10):
pubmed: 30275402
Sci Rep. 2017 Mar 14;7:44544
pubmed: 28291251
Hepatology. 2001 Nov;34(5):953-63
pubmed: 11679966
Ann Transl Med. 2016 Dec;4(24):512
pubmed: 28149874
Circ Res. 2003 May 2;92(8):827-39
pubmed: 12730128
J Clin Invest. 2015 Apr;125(4):1579-90
pubmed: 25798621
Nat Rev Gastroenterol Hepatol. 2019 May;16(5):269-281
pubmed: 30850822
Hepatology. 2016 Jan;63(1):185-96
pubmed: 26044703
Hepatology. 2017 Feb;65(2):544-559
pubmed: 27639079
Arch Pharm Res. 2015 Apr;38(4):549-55
pubmed: 25005065
J Hepatol. 2009 Jun;50(6):1102-11
pubmed: 19398228
Semin Liver Dis. 2006 Feb;26(1):22-30
pubmed: 16496230
J Nutr. 2012 Oct;142(10):1821-8
pubmed: 22915297
Curr Opin Gastroenterol. 2017 Mar;33(2):71-77
pubmed: 28030370
J Med Food. 2015 Mar;18(3):290-8
pubmed: 25133972
J Clin Invest. 2003 Dec;112(12):1776-84
pubmed: 14679171
Nat Rev Immunol. 2018 May;18(5):309-324
pubmed: 29379212
Gut. 2010 Apr;59(4):521-30
pubmed: 20332524
Gastroenterology. 2004 Nov;127(5):1565-77
pubmed: 15521023
Int J Pharm. 2019 Jun 30;565:64-69
pubmed: 31071415
Scand J Gastroenterol. 2019 May;54(5):633-639
pubmed: 31131678
Am J Gastroenterol. 2015 May;110(5):646-59; quiz 660
pubmed: 25869391
Eur J Gastroenterol Hepatol. 2016 May;28(5):508-13
pubmed: 26872110
Dig Dis Sci. 2008 Jun;53(6):1716-20
pubmed: 17940903
Integr Cancer Ther. 2007 Jun;6(2):104-9
pubmed: 17548789
J Biol Chem. 2004 Mar 19;279(12):11392-401
pubmed: 14702344
Nutrients. 2016 Mar 15;8(3):167
pubmed: 26999194
Br J Pharmacol. 2008 Feb;153(3):557-67
pubmed: 17965732
Molecules. 2015 May 20;20(5):9183-213
pubmed: 26007179
World J Gastroenterol. 2005 Aug 28;11(32):4931-8
pubmed: 16124041
Front Pharmacol. 2018 Feb 09;9:72
pubmed: 29497376
J Viral Hepat. 2008 Jul;15(7):508-14
pubmed: 18397225
PLoS One. 2014 Oct 15;9(10):e109608
pubmed: 25333702
J Gastroenterol Hepatol. 1998 Sep;13(S1):S33-S38
pubmed: 28976699
Molecules. 2019 Mar 21;24(6):
pubmed: 30901869
Expert Opin Emerg Drugs. 2008 Mar;13(1):145-58
pubmed: 18321154
Biochem J. 2004 Nov 15;384(Pt 1):149-57
pubmed: 15320868
Gut. 2011 Jan;60(1):90-8
pubmed: 20660699
Sci Rep. 2017 Aug 24;7(1):9289
pubmed: 28839277
Gastroenterology. 2010 Mar;138(3):1102-11
pubmed: 19944697
Gut. 2016 Oct;65(10):1681-9
pubmed: 27207975
Dig Dis Sci. 2007 Sep;52(9):2387-95
pubmed: 17410454
Mol Aspects Med. 2000 Jun;21(3):49-98
pubmed: 10978499
World J Gastroenterol. 2011 May 14;17(18):2288-301
pubmed: 21633595
J Hepatol. 2011 Dec;55(6):1353-60
pubmed: 21803012
Oxid Med Cell Longev. 2014;2014:169216
pubmed: 24987492
J Ethnopharmacol. 2016 Jul 21;188:193-9
pubmed: 27178632
Phytother Res. 2010 Feb;24(2):198-204
pubmed: 19610045
Arch Physiol Biochem. 2008 Apr;114(2):127-49
pubmed: 18484280
BMC Complement Altern Med. 2013 Mar 05;13:56
pubmed: 23496995
Front Immunol. 2016 Jan 29;7:19
pubmed: 26858722
J Hepatol. 2014 Jun;60(6):1290-303
pubmed: 24560657
Gastroenterology. 2000 Aug;119(2):466-78
pubmed: 10930382
Biomed Pharmacother. 2017 Mar;87:223-229
pubmed: 28061405
Am J Physiol Gastrointest Liver Physiol. 2006 May;290(5):G883-93
pubmed: 16306131
Nat Genet. 2011 Jan;43(1):17-9
pubmed: 21151127
ISRN Inflamm. 2012 Oct 16;2012:954032
pubmed: 24049654