Exploring the Bacterial Impact on Cholesterol Cycle: A Numerical Study.
cholesterol metabolism
functional ecology
holobiont
mathematical model
microbiome
microbiota
system biology
whole body model
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2020
2020
Historique:
received:
10
01
2020
accepted:
05
05
2020
entrez:
27
6
2020
pubmed:
27
6
2020
medline:
27
6
2020
Statut:
epublish
Résumé
High blood cholesterol levels are often associated with cardiovascular diseases. Therapeutic strategies, targeting different functions involved in cholesterol transport or synthesis, were developed to control cholesterolemia in human. However, the gut microbiota is also involved in cholesterol regulation by direct biotransformation of luminal cholesterol or conversion of bile salts, opening the way to the design of new strategies to manage cholesterol level. In this report, we developed for the first time a whole-body human model of cholesterol metabolism including the gut microbiota in order to investigate the relative impact of host and microbial pathways. We first used an animal model to investigate the ingested cholesterol distribution
Identifiants
pubmed: 32587579
doi: 10.3389/fmicb.2020.01121
pmc: PMC7298119
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1121Informations de copyright
Copyright © 2020 Bourgin, Labarthe, Kriaa, Lhomme, Gérard, Lesnik, Laroche, Maguin and Rhimi.
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