Purifying Selection in Human Immunodeficiency Virus-1

Adolescents Children HIV-1 pol gene Immunovirological dissociation Nonsynonymous mutations Purifying selection Synonymous mutations Virological failure

Journal

Journal of clinical medicine research
ISSN: 1918-3003
Titre abrégé: J Clin Med Res
Pays: Canada
ID NLM: 101538301

Informations de publication

Date de publication:
Jun 2020
Historique:
received: 07 04 2020
accepted: 23 04 2020
entrez: 27 6 2020
pubmed: 27 6 2020
medline: 27 6 2020
Statut: ppublish

Résumé

Biological monitoring of antiretroviral treatment (ART) in human immunodeficiency virus (HIV)-infected pediatric population remains challenging. The aim of the present study was to assess the long-term HIV-1 genetic diversity in HIV-1 diversity in The immunological responses to ART basically corresponded to: 1) Full therapeutic failure with immunological (I Children and adolescents in immunovirological therapeutic failure harbor positive selection of HIV-1 strains favoring diversifying in

Sections du résumé

BACKGROUND BACKGROUND
Biological monitoring of antiretroviral treatment (ART) in human immunodeficiency virus (HIV)-infected pediatric population remains challenging. The aim of the present study was to assess the long-term HIV-1 genetic diversity in
METHODS METHODS
HIV-1 diversity in
RESULTS RESULTS
The immunological responses to ART basically corresponded to: 1) Full therapeutic failure with immunological (I
CONCLUSIONS CONCLUSIONS
Children and adolescents in immunovirological therapeutic failure harbor positive selection of HIV-1 strains favoring diversifying in

Identifiants

DOI: 10.14740/jocmr4157 PMID: 32587653 PMC: PMC7295550
pubmed: 32587653
doi: 10.14740/jocmr4157
pmc: PMC7295550
doi:

Types de publication

Journal Article

Langues

eng

Pagination

369-376

Informations de copyright

Copyright 2020, Mboumba Bouassa et al.

Déclaration de conflit d'intérêts

The authors declare that there is no conflict of interest regarding the publication of this paper.

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Auteurs

Ralph-Sydney Mboumba Bouassa (RS)

Laboratoire de Virologie, Hopital Europeen Georges Pompidou, Assistance Publique-Hopitaux de Paris (AP-HP) and Universite de Paris, Paris Sorbonne Cite, Paris, France.
Ecole Doctorale Regionale en Infectiologie Tropicale, Franceville, Gabon.

Helene Pere (H)

Laboratoire de Virologie, Hopital Europeen Georges Pompidou, Assistance Publique-Hopitaux de Paris (AP-HP) and Universite de Paris, Paris Sorbonne Cite, Paris, France.
Universite de Paris, Paris Sorbonne Cite, Paris, France.

Christian Diamant Mossoro-Kpinde (CD)

Faculte des Sciences de la Sante, Universite de Bangui, Bangui, Central African Republic.
Laboratoire National de Biologie Clinique et de Sante Publique, Bangui, Central African Republic.

Pierre Roques (P)

Commissariat a l'Energie Atomique (CEA)-Universite Paris-Saclay; INSERM U1184, Immunology of Viral Infections and Autoimmune Diseases (IMVA), IDMIT Department, Institut de Biologie Francois-Jacob (IBJF), Fontenay-aux-Roses, France.

Jean Chrysostome Gody (JC)

Faculte des Sciences de la Sante, Universite de Bangui, Bangui, Central African Republic.
Complexe Pediatrique, Bangui, Central African Republic.

Sandrine Moussa (S)

Institut Pasteur de Bangui, Bangui, Central African Republic.

David Veyer (D)

Laboratoire de Virologie, Hopital Europeen Georges Pompidou, Assistance Publique-Hopitaux de Paris (AP-HP) and Universite de Paris, Paris Sorbonne Cite, Paris, France.

Gerard Gresenguet (G)

Faculte des Sciences de la Sante, Universite de Bangui, Bangui, Central African Republic.
Unite de Recherches et d'Intervention sur les Maladies Sexuellement Transmissibles et le SIDA, Departement de Sante Publique, Faculte des Sciences de la Sante de Bangui, Central African Republic.

Charlotte Charpentier (C)

IAME, UMR 1137, INSERM, Universite Paris Diderot, Sorbonne Paris Cite, AP-HP, Laboratoire de Virologie, Hopital Bichat, AP-HP, Paris, France.

Mohammad-Ali Jenabian (MA)

Departement des Sciences Biologiques et Centre de Recherche BioMed, Universite du Quebec a Montreal (UQAM), Montreal, QC, Canada.

Joel Fleury Djoba Siawaya (JF)

Ecole Doctorale Regionale en Infectiologie Tropicale, Franceville, Gabon.
Laboratory Medicine, Mother and Child University Hospital Jeanne Ebori, Libreville, Gabon.

Laurent Belec (L)

Laboratoire de Virologie, Hopital Europeen Georges Pompidou, Assistance Publique-Hopitaux de Paris (AP-HP) and Universite de Paris, Paris Sorbonne Cite, Paris, France.
Ecole Doctorale Regionale en Infectiologie Tropicale, Franceville, Gabon.
Universite de Paris, Paris Sorbonne Cite, Paris, France.

Classifications MeSH