IFNγ Production Profile in Turkeys of Different Immunological Status after TRT Vaccination.
avian metapneumovirus
maternally derived antibodies
turkeys
vaccination
Journal
Journal of veterinary research
ISSN: 2450-7393
Titre abrégé: J Vet Res
Pays: Poland
ID NLM: 101696630
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
03
03
2020
accepted:
18
05
2020
entrez:
27
6
2020
pubmed:
27
6
2020
medline:
27
6
2020
Statut:
epublish
Résumé
Despite vaccination against avian metapneumoviruses (aMPV), cases of turkey rhinotracheitis (TRT) caused by aMPV field strains are frequently reported. Differences have been shown in the level of immune system stimulation after aMPV vaccination between turkeys that do and do not possess specific anti-aMPV maternally derived antibodies (MDA). The article describes the influence of MDA on the production of IFNγ in the spleen of aMPV-vaccinated turkeys. MDA+ or MDA- turkeys were vaccinated against TRT after hatching or on the 14 Increased IFNγ gene expression was noticed after vaccination only in birds that did not possess MDA or possessed MDA at relatively low level (MDA+ birds vaccinated at 14 DOL). In all birds, an increased percentage of T lymphocytes producing IFNγ was recorded. The proportion of anti-aMPV IFNγ-secreting cells was increased only in MDA- birds. Besides having a protective role, MDA are known to interfere with vaccination efficacy. The analysis of our results confirms that MDA can decrease the level of immune system stimulation after aMPV vaccination of turkeys.
Identifiants
pubmed: 32587910
doi: 10.2478/jvetres-2020-0040
pii: jvetres-2020-0040
pmc: PMC7305653
doi:
Types de publication
Journal Article
Langues
eng
Pagination
239-245Informations de copyright
© 2020 M. Śmiałek et al. published by Sciendo.
Déclaration de conflit d'intérêts
Conflict of Interest Conflict of Interests Statement: The authors declare that there is no conflict of interests regarding the publication of this article.
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