Recurrent Amplification of the Osmotic Stress Transcription Factor
Adrenocortical carcinoma
NFAT5
Osmotic Stress
and SLC5A3
Journal
Journal of the Endocrine Society
ISSN: 2472-1972
Titre abrégé: J Endocr Soc
Pays: United States
ID NLM: 101697997
Informations de publication
Date de publication:
01 Jul 2020
01 Jul 2020
Historique:
received:
31
03
2020
accepted:
20
05
2020
entrez:
27
6
2020
pubmed:
27
6
2020
medline:
27
6
2020
Statut:
epublish
Résumé
Tumorigenesis requires mitigation of osmotic stress and the transcription factor nuclear factor of activated T cells 5 (NFAT5) coordinates this response by inducing transcellular transport of ions and osmolytes. NFAT5 modulates in vitro behavior in several cancer types, but a potential role of NFAT5 in adrenocortical carcinoma (ACC) has not been studied. A discovery cohort of 28 ACCs was selected for analysis. Coverage depth analysis of whole-exome sequencing reads assessed
Identifiants
pubmed: 32587934
doi: 10.1210/jendso/bvaa060
pii: bvaa060
pmc: PMC7304660
doi:
Types de publication
Journal Article
Langues
eng
Pagination
bvaa060Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Informations de copyright
© Endocrine Society 2020.
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