Development of methylthiosemicarbazones as new reversible monoamine oxidase-B inhibitors for the treatment of Parkinson's disease.

Animals Chlorocebus aethiops Kinetics Molecular Docking Simulation Monoamine Oxidase Monoamine Oxidase Inhibitors / pharmacology Parkinson Disease / drug therapy Structure-Activity Relationship Vero Cells
Kinetics Parkinson’s disease methylthiosemicarbazones molecular dynamics monoamine oxidase reversibility

Journal

Journal of biomolecular structure & dynamics
ISSN: 1538-0254
Titre abrégé: J Biomol Struct Dyn
Pays: England
ID NLM: 8404176

Informations de publication

Date de publication:
Aug 2021
Historique:
pubmed: 27 6 2020
medline: 12 8 2021
entrez: 27 6 2020
Statut: ppublish

Résumé

Selective monoamine oxidase-B (MAO-B) inhibition is an attractive subject for the treatment of Parkinson's disease (PD). In the current study, we synthesized some selected derivatives of methylthiosemicarbazones and investigated their MAOs and acetylcholinesterase (AChE) inhibitory activities. Among the series synthesized, compounds

Identifiants

DOI: 10.1080/07391102.2020.1782266 PMID: 32588753
pubmed: 32588753
doi: 10.1080/07391102.2020.1782266
doi:

Substances chimiques

Monoamine Oxidase Inhibitors 0
Monoamine Oxidase EC 1.4.3.4

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

4786-4794

Auteurs

Githa Elizabeth Mathew (GE)

Department of Pharmacology, Grace College of Pharmacy, Palakkad, Kerala, India.
Department of Pharmaceutical Chemistry, Vinayaka Mission's College of Pharmacy, Vinayaka Mission's Research Foundation (Deemed to be a University), Tamilnadu, Salem, India.
ORCID: 0000-0002-4237-9552

Jong Min Oh (JM)

Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon, Republic of Korea.

Kumar Mohan (K)

Department of Pharmaceutical Chemistry, Vinayaka Mission's College of Pharmacy, Vinayaka Mission's Research Foundation (Deemed to be a University), Tamilnadu, Salem, India.

Anandkumar Tengli (A)

Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Mysuru, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India.

Bijo Mathew (B)

Department of Pharmaceutical Chemistry, Division of Drug Design and Medicinal Chemistry Research Lab, Ahalia School of Pharmacy, Palakkad, Kerala, India.
ORCID: 0000-0002-6658-4497

Hoon Kim (H)

Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon, Republic of Korea.
ORCID: 0000-0002-7203-3712

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Development of methylthiosemicarbazones as new...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Cercopithecus › Cercopithecus aethiops › Development of methylthiosemicarbazones as new...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › Development of methylthiosemicarbazones as new...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Development of methylthiosemicarbazones as new...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-NH2 group donors › Monoamine oxidase › Development of methylthiosemicarbazones as new...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de la monoamine oxydase › Development of methylthiosemicarbazones as new...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › Development of methylthiosemicarbazones as new...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Development of methylthiosemicarbazones as new...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules Vero › Development of methylthiosemicarbazones as new...