A Matlab-based toolbox for characterizing behavior of rodents engaged in string-pulling.
biomechanics
hand kinematics
matlab toolbox
mouse
neuroscience
rat
sensorimotor integration
string-pulling
swiss webster c57bl/6
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
26 06 2020
26 06 2020
Historique:
received:
18
12
2019
accepted:
26
06
2020
pubmed:
27
6
2020
medline:
17
2
2021
entrez:
27
6
2020
Statut:
epublish
Résumé
String-pulling by rodents is a behavior in which animals make rhythmical body, head, and bilateral forearm as well as skilled hand movements to spontaneously reel in a string. Typical analysis includes kinematic assessment of hand movements done by manually annotating frames. Here, we describe a Matlab-based software that allows whole-body motion characterization using optical flow estimation, descriptive statistics, principal component, and independent component analyses as well as temporal measures of Fano factor, entropy, and Higuchi fractal dimension. Based on image-segmentation and heuristic algorithms for object tracking, the software also allows tracking of body, ears, nose, and forehands for estimation of kinematic parameters such as body length, body angle, head roll, head yaw, head pitch, and path and speed of hand movements. The utility of the task and software is demonstrated by characterizing postural and hand kinematic differences in string-pulling behavior of two strains of mice, C57BL/6 and Swiss Webster.
Identifiants
pubmed: 32589141
doi: 10.7554/eLife.54540
pii: 54540
pmc: PMC7347385
doi:
pii:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : CIHR
ID : 390930
Pays : Canada
Organisme : Natural Sciences and Engineering Research Council of Canada
ID : 40352
Pays : International
Organisme : Alberta Innovates
ID : 43568
Pays : International
Organisme : Alberta Alzheimer Research Program Grant
ID : PAZ15010
Pays : International
Organisme : Alberta Alzheimer Research Program Grant
ID : PAZ17010
Pays : International
Organisme : Alzheimer Society of Canada
ID : 43674
Pays : International
Organisme : CIHR
ID : 390930
Pays : Canada
Informations de copyright
© 2020, Inayat et al.
Déclaration de conflit d'intérêts
SI, SS, AG, Q, PE, IW, MM No competing interests declared
Références
Behav Brain Res. 2018 Feb 15;338:88-100
pubmed: 29037663
Front Syst Neurosci. 2019 May 07;13:20
pubmed: 31133826
Sleep. 2020 Jun 15;43(6):
pubmed: 31825510
Anim Cogn. 2008 Apr;11(2):223-30
pubmed: 17710453
Nat Neurosci. 2018 Sep;21(9):1281-1289
pubmed: 30127430
Nat Rev Neurosci. 2017 May;18(5):267-280
pubmed: 28331232
Ann N Y Acad Sci. 2005 Jun;1048:427-9
pubmed: 16154967
Nat Protoc. 2019 Jul;14(7):2152-2176
pubmed: 31227823
J Comp Psychol. 2015 May;129(2):89-120
pubmed: 25984937
Nat Methods. 2013 Jan;10(1):64-7
pubmed: 23202433
Brain Res Bull. 2002 Nov 30;59(3):197-203
pubmed: 12431749
Behav Brain Res. 1996 Aug;78(2):101-11
pubmed: 8864042
Neuron. 2019 Feb 6;101(3):421-428.e5
pubmed: 30658859
Methods Mol Biol. 2018;1780:121-141
pubmed: 29856017
Stroke. 2002 Jul;33(7):1869-75
pubmed: 12105368
Lipids. 2016 May;51(5):549-60
pubmed: 26797754
Behav Brain Res. 2003 Oct 17;145(1-2):221-32
pubmed: 14529819
Neural Netw. 2000 May-Jun;13(4-5):411-30
pubmed: 10946390
Behav Brain Res. 2018 Jun 1;345:49-58
pubmed: 29474809
Exp Brain Res. 2019 Dec;237(12):3431-3447
pubmed: 31734786
PLoS Biol. 2019 Nov 21;17(11):e3000516
pubmed: 31751328
Elife. 2020 Jun 26;9:
pubmed: 32589141
Neurosci Biobehav Rev. 2013 Jun;37(5):950-67
pubmed: 23583614
Front Cell Neurosci. 2018 Jun 21;12:173
pubmed: 29977191
Neuroimage. 2017 Jun;153:58-74
pubmed: 28351691