Adiposity and physical activity are related to heart rate variability: the African-PREDICT study.
adiposity
ethnicity
heart rate variability
physical activity
Journal
European journal of clinical investigation
ISSN: 1365-2362
Titre abrégé: Eur J Clin Invest
Pays: England
ID NLM: 0245331
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
27
04
2020
revised:
11
06
2020
accepted:
18
06
2020
pubmed:
27
6
2020
medline:
5
10
2021
entrez:
27
6
2020
Statut:
ppublish
Résumé
Physical inactivity contributes significantly to the development of obesity-related cardiovascular disease. Adiposity may lead to reduced heart rate variability (HRV), whereas increased physical activity (PA) has the potential to improve autonomic activity. These associations remain largely unexplored in healthy individuals. We therefore investigated whether adiposity and physical activity (PA) are associated with reduced heart rate variability (HRV) in young adults. We examined 403 black and 461 white healthy adults (aged 20-30 years) for HRV, including standard deviation of normal RR intervals (SDNN) and root mean square of successive differences (RMSSD). We measured adiposity, PA levels and blood pressure (BP). Body mass index (BMI) of ≥ 30 kg/m Participants with obesity had lower mean HRV than normal weight (SDNN [95% CI]; 138 [131-145]s vs 161 [158-165]ms), where those with the highest PA had higher SDNN (164 [160-169]ms) and RMSSD (51 [49-53]ms) than the least active individuals (150 [146-155]s) and 46 [44-48]ms)(all P < .01). BMI, waist circumference and body fat associated with lower SDNN (P < .001). With each unit increase of vigorous PA, a favourable higher RMSSD was found (P < .05). One unit increase in diastolic BP was associated with decreased SDNN and RMSSD (P < .001). These findings remained significant in multivariable-adjusted analyses. Adiposity and low PA associated independently with depressed autonomic activity in young healthy adults. Sympathovagal imbalance seems to already contribute to elevated diastolic BP at young ages. Our study supports population-based prevention programmes in young adults, improving PA and healthy diet, to curb the development of cardiovascular disease.
Sections du résumé
BACKGROUND
BACKGROUND
Physical inactivity contributes significantly to the development of obesity-related cardiovascular disease. Adiposity may lead to reduced heart rate variability (HRV), whereas increased physical activity (PA) has the potential to improve autonomic activity. These associations remain largely unexplored in healthy individuals. We therefore investigated whether adiposity and physical activity (PA) are associated with reduced heart rate variability (HRV) in young adults.
MATERIALS AND METHODS
METHODS
We examined 403 black and 461 white healthy adults (aged 20-30 years) for HRV, including standard deviation of normal RR intervals (SDNN) and root mean square of successive differences (RMSSD). We measured adiposity, PA levels and blood pressure (BP). Body mass index (BMI) of ≥ 30 kg/m
RESULTS
RESULTS
Participants with obesity had lower mean HRV than normal weight (SDNN [95% CI]; 138 [131-145]s vs 161 [158-165]ms), where those with the highest PA had higher SDNN (164 [160-169]ms) and RMSSD (51 [49-53]ms) than the least active individuals (150 [146-155]s) and 46 [44-48]ms)(all P < .01). BMI, waist circumference and body fat associated with lower SDNN (P < .001). With each unit increase of vigorous PA, a favourable higher RMSSD was found (P < .05). One unit increase in diastolic BP was associated with decreased SDNN and RMSSD (P < .001). These findings remained significant in multivariable-adjusted analyses.
CONCLUSIONS
CONCLUSIONS
Adiposity and low PA associated independently with depressed autonomic activity in young healthy adults. Sympathovagal imbalance seems to already contribute to elevated diastolic BP at young ages. Our study supports population-based prevention programmes in young adults, improving PA and healthy diet, to curb the development of cardiovascular disease.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13330Subventions
Organisme : Department of Science and Technology and National Research Foundation (NRF) of South Africa
ID : GUN 86895
Organisme : UK Medical Research Council and with funds from the UK Government's Newton Fund
Organisme : South African Research Chairs Initiative
Organisme : North-West University
Organisme : South African Medical Research Council
Organisme : Treasury
Organisme : Department of Science and Technology
Organisme : National Research Foundation
Organisme : National Department of Health
Organisme : GlaxoSmithKline
Organisme : Newton Fund
Organisme : Pfizer
Organisme : Boehringer Ingelheim
Organisme : Novartis
Organisme : Roche
Organisme : Medical Research Council
Pays : United Kingdom
Informations de copyright
© 2020 Stichting European Society for Clinical Investigation Journal Foundation.
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