Thiopeptides Induce Proteasome-Independent Activation of Cellular Mitophagy.
Animals
Anti-Bacterial Agents
/ pharmacology
Eukaryotic Initiation Factor-2
/ metabolism
Forkhead Box Protein M1
/ metabolism
Mice
Mitophagy
/ drug effects
Mycobacterium tuberculosis
/ drug effects
Peptides
/ chemistry
Phosphorylation
Proteasome Endopeptidase Complex
/ metabolism
RAW 264.7 Cells
Sulfhydryl Compounds
/ chemistry
Journal
ACS chemical biology
ISSN: 1554-8937
Titre abrégé: ACS Chem Biol
Pays: United States
ID NLM: 101282906
Informations de publication
Date de publication:
21 08 2020
21 08 2020
Historique:
pubmed:
27
6
2020
medline:
7
5
2021
entrez:
27
6
2020
Statut:
ppublish
Résumé
Thiopeptide antibiotics are emerging clinical candidates that exhibit potent antibacterial activity against a variety of intracellular pathogens, including
Identifiants
pubmed: 32589399
doi: 10.1021/acschembio.0c00364
pmc: PMC7442609
mid: NIHMS1608962
doi:
Substances chimiques
Anti-Bacterial Agents
0
Eukaryotic Initiation Factor-2
0
Forkhead Box Protein M1
0
Foxm1 protein, mouse
0
Peptides
0
Sulfhydryl Compounds
0
Proteasome Endopeptidase Complex
EC 3.4.25.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2164-2174Subventions
Organisme : NCI NIH HHS
ID : P30 CA016086
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI138058
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM125005
Pays : United States
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