Cognitive enhancement of healthy older adults using hyperbaric oxygen: a randomized controlled trial.
Aged
Attention
/ physiology
Brain
Cerebrovascular Circulation
Cognition
/ physiology
Cognitive Dysfunction
/ diagnosis
Female
Healthy Aging
/ physiology
Healthy Volunteers
Humans
Hyperbaric Oxygenation
Magnetic Resonance Angiography
Magnetic Resonance Imaging
Male
Neuropsychological Tests
/ statistics & numerical data
Treatment Outcome
aging
cerebral blood flow
cognitive
hyperbaric oxygen
perfusion
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
26 06 2020
26 06 2020
Historique:
received:
06
05
2020
accepted:
09
06
2020
pubmed:
27
6
2020
medline:
9
3
2021
entrez:
27
6
2020
Statut:
ppublish
Résumé
More than half of community-dwelling individuals sixty years and older express concern about declining cognitive abilities. The current study's aim was to evaluate hyperbaric oxygen therapy (HBOT) effect on cognitive functions in healthy aging adults.A randomized controlled clinical trial randomized 63 healthy adults (>64) either to HBOT(n=33) or control arms(n=30) for three months. Primary endpoint included the general cognitive function measured post intervention/control. Cerebral blood flow (CBF) was evaluated by perfusion magnetic resonance imaging.There was a significant group-by-time interaction in global cognitive function post-HBOT compared to control (p=0.0017). The most striking improvements were in attention (net effect size=0.745) and information processing speed (net effect size=0.788).Voxel-based analysis showed significant cerebral blood flow increases in the HBOT group compared to the control group in the right superior medial frontal gyrus (BA10), right and left supplementary motor area (BA6), right middle frontal gyrus (BA6), left middle frontal gyrus (BA9), left superior frontal gyrus (BA8) and the right superior parietal gyrus (BA7).In this study, HBOT was shown to induce cognitive enhancements in healthy aging adults via mechanisms involving regional changes in CBF. The main improvements include attention, information processing speed and executive functions, which normally decline with aging.
Identifiants
pubmed: 32589613
pii: 103571
doi: 10.18632/aging.103571
pmc: PMC7377835
doi:
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13740-13761Références
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