Plasmodium falciparum sexual parasites develop in human erythroblasts and affect erythropoiesis.
Journal
Blood
ISSN: 1528-0020
Titre abrégé: Blood
Pays: United States
ID NLM: 7603509
Informations de publication
Date de publication:
17 09 2020
17 09 2020
Historique:
received:
27
12
2019
accepted:
01
06
2020
pubmed:
27
6
2020
medline:
20
3
2021
entrez:
27
6
2020
Statut:
ppublish
Résumé
Plasmodium falciparum gametocytes, the sexual stage responsible for malaria parasite transmission from humans to mosquitoes, are key targets for malaria elimination. Immature gametocytes develop in the human bone marrow parenchyma, where they accumulate around erythroblastic islands. Notably though, the interactions between gametocytes and this hematopoietic niche have not been investigated. Here, we identify late erythroblasts as a new host cell for P falciparum sexual stages and show that gametocytes can fully develop inside these nucleated cells in vitro and in vivo, leading to infectious mature gametocytes within reticulocytes. Strikingly, we found that infection of erythroblasts by gametocytes and parasite-derived extracellular vesicles delay erythroid differentiation, thereby allowing gametocyte maturation to coincide with the release of their host cell from the bone marrow. Taken together, our findings highlight new mechanisms that are pivotal for the maintenance of immature gametocytes in the bone marrow and provide further insights on how Plasmodium parasites interfere with erythropoiesis and contribute to anemia in malaria patients.
Identifiants
pubmed: 32589714
pii: S0006-4971(20)61699-8
doi: 10.1182/blood.2019004746
pmc: PMC7498361
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1381-1393Subventions
Organisme : Medical Research Council
ID : MR/S009450/1
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : U19 AI089676
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 by The American Society of Hematology.
Références
Mem Inst Oswaldo Cruz. 1992;87 Suppl 3:91-4
pubmed: 1343731
Blood. 2011 Nov 10;118(19):5071-9
pubmed: 21885599
Mol Biochem Parasitol. 2007 Jul;154(1):119-23
pubmed: 17521751
Cell Host Microbe. 2013 May 15;13(5):521-534
pubmed: 23684304
Am J Hematol. 2010 Apr;85(4):234-7
pubmed: 20196166
Blood. 2014 Feb 13;123(7):959-66
pubmed: 24335496
Sci Rep. 2018 Dec 14;8(1):17886
pubmed: 30552367
J Exp Med. 1993 Feb 1;177(2):273-81
pubmed: 8426106
Mol Cell Proteomics. 2010 Jul;9(7):1437-48
pubmed: 20332084
Cell. 2013 May 23;153(5):1120-33
pubmed: 23683579
Cell Microbiol. 2013 Apr;15(4):647-59
pubmed: 23114006
Sci Transl Med. 2014 Jul 9;6(244):244re5
pubmed: 25009232
Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6442-7
pubmed: 17404235
Exp Hematol. 2016 Oct;44(10):975-81
pubmed: 27364565
J Cell Sci. 2012 Apr 15;125(Pt 8):2053-63
pubmed: 22328505
Science. 2015 May 8;348(6235):711-4
pubmed: 25954012
Malar J. 2018 Oct 19;17(1):371
pubmed: 30340592
EMBO J. 1992 Jun;11(6):2293-301
pubmed: 1600948
Methods Mol Biol. 2017;1660:377-388
pubmed: 28828673
Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):E9356-E9365
pubmed: 29078358
Infect Immun. 2008 Dec;76(12):5565-80
pubmed: 18809668
Parasitology. 2018 Dec;145(14):1865-1875
pubmed: 29739485
Cell Rep. 2016 Aug 2;16(5):1470-1484
pubmed: 27452463
Trans R Soc Trop Med Hyg. 1971;65(5):549-59
pubmed: 5003557
Nat Protoc. 2016 Sep;11(9):1668-80
pubmed: 27560172
Mol Biochem Parasitol. 2008 Dec;162(2):172-6
pubmed: 18848585
Front Microbiol. 2019 Nov 08;10:2652
pubmed: 31787966
Parasitology. 1982 Feb;84(1):1-11
pubmed: 7038594
PLoS One. 2011 May 04;6(5):e19307
pubmed: 21573240
Cell. 2016 Jan 14;164(1-2):246-257
pubmed: 26771494
Blood. 2012 Jun 14;119(24):e172-80
pubmed: 22517905
PLoS Pathog. 2018 Oct 4;14(10):e1007298
pubmed: 30286211
Am J Hematol. 2019 Sep;94(9):963-974
pubmed: 31148215
Mol Microbiol. 2007 Jun;64(6):1621-34
pubmed: 17555442
Front Med (Lausanne). 2019 Apr 16;6:75
pubmed: 31058153
Elife. 2019 Oct 29;8:
pubmed: 31658944
Sci Transl Med. 2019 Jun 5;11(495):
pubmed: 31167926
Front Cell Infect Microbiol. 2018 Mar 01;8:50
pubmed: 29546035
PLoS One. 2012;7(2):e31567
pubmed: 22363675
Nat Commun. 2016 Oct 10;7:12727
pubmed: 27721445
Science. 1976 Aug 20;193(4254):673-5
pubmed: 781840
Cell Microbiol. 2012 Jul;14(7):983-93
pubmed: 22417683
Blood. 2015 Feb 19;125(8):1314-24
pubmed: 25414440
Blood. 2009 Oct 22;114(17):3652-5
pubmed: 19706885
Malar J. 2012 Aug 20;11:285
pubmed: 22905863
Rev Hematol. 1958 Jan-Mar;13(1):8-11
pubmed: 13555228