Colloidal polymer-coated Zn-doped iron oxide nanoparticles with high relaxivity and specific absorption rate for efficient magnetic resonance imaging and magnetic hyperthermia.
Cancer theranostic
High relaxivity
High specific absorption rate
Iron oxide nanoparticle
Polymer coating
Superparamagnetism
Zinc doping
Journal
Journal of colloid and interface science
ISSN: 1095-7103
Titre abrégé: J Colloid Interface Sci
Pays: United States
ID NLM: 0043125
Informations de publication
Date de publication:
01 Nov 2020
01 Nov 2020
Historique:
received:
06
02
2020
revised:
29
05
2020
accepted:
30
05
2020
pubmed:
27
6
2020
medline:
22
6
2021
entrez:
27
6
2020
Statut:
ppublish
Résumé
Colloidally stable nanoparticles-based magnetic agents endowed with very high relaxivity and specific absorption rate are extremely desirable for efficient magnetic resonance imaging and magnetic hyperthermia, respectively. Here, we report a water dispersible magnetic agent consisting of zinc-doped superparamagnetic iron oxide nanoparticles (i.e., Zn-SPIONs) of 15 nm size with high saturation magnetization coated with an amphiphilic polymer for effective magnetic resonance imaging and magnetic hyperthermia of glioblastoma cells. These biocompatible polymer-coated Zn-SPIONs had 24 nm hydrodynamic diameter and exhibited high colloidal stability in various aqueous media, very high transverse relaxivity of 471 mM
Identifiants
pubmed: 32590159
pii: S0021-9797(20)30735-9
doi: 10.1016/j.jcis.2020.05.119
pii:
doi:
Substances chimiques
Contrast Media
0
Magnetite Nanoparticles
0
Polymers
0
Zinc
J41CSQ7QDS
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
186-194Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.