Smart responsive-calcium carbonate nanoparticles for dual-model cancer imaging and treatment.
Animals
Calcium Carbonate
/ chemistry
Carbon Dioxide
/ metabolism
Cell Line, Tumor
Contrast Media
Doxorubicin
/ chemistry
Drug Carriers
/ chemistry
Fluorescence
Hydrogen-Ion Concentration
Male
Mice
Mice, Inbred BALB C
Microscopy, Confocal
Microscopy, Electron, Transmission
Multimodal Imaging
Nanoparticles
/ chemistry
Neoplasms, Experimental
/ diagnostic imaging
Theranostic Nanomedicine
/ methods
Tumor Microenvironment
Ultrasonography
/ methods
CaCO(3) nanoparticles
Contrast-enhanced ultrasound
Dual-model imaging
Journal
Ultrasonics
ISSN: 1874-9968
Titre abrégé: Ultrasonics
Pays: Netherlands
ID NLM: 0050452
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
14
08
2019
revised:
22
05
2020
accepted:
28
05
2020
pubmed:
27
6
2020
medline:
26
9
2020
entrez:
27
6
2020
Statut:
ppublish
Résumé
Contrast-enhanced ultrasound (CEUS) is widely applied in cancer diagnosis clinically. However, the gas-filled contrast agents are unstable in the blood and exhibit shorter imaging time, which limit their clinical use. In this study, a diagnostic nanoparticle system was developed for dual-mode imaging (ultrasound and fluorescence), which after encapsulation with doxorubicin (DOX) demonstrated simultaneous therapeutic function towards cancer treatment. Thus, calcium carbonate (CaCO
Identifiants
pubmed: 32590261
pii: S0041-624X(20)30137-2
doi: 10.1016/j.ultras.2020.106198
pii:
doi:
Substances chimiques
Contrast Media
0
Drug Carriers
0
Carbon Dioxide
142M471B3J
Doxorubicin
80168379AG
Calcium Carbonate
H0G9379FGK
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
106198Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.