Arthropod exosomes as bubbles with message(s) to transmit vector-borne diseases.
Journal
Current opinion in insect science
ISSN: 2214-5753
Titre abrégé: Curr Opin Insect Sci
Pays: Netherlands
ID NLM: 101635599
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
14
02
2020
revised:
22
05
2020
accepted:
27
05
2020
pubmed:
27
6
2020
medline:
14
1
2021
entrez:
27
6
2020
Statut:
ppublish
Résumé
Ticks and mosquitoes are medically important vectors that transmit several pathogens, including arboviruses, to humans. Understanding how these blood-feeding arthropods transmit pathogens to humans requires knowledge on the molecular and cellular interplay at vector-host interface. Recent studies have highlighted the role of tick and mosquito small extracellular vesicles (EVs), including exosomes, facilitating arbovirus transmission within arthropod cells and from arthropod to mammalian cells. In this review, we summarize this emerging line of investigation in understanding the role of tick and mosquito exosomes in vector-pathogen-host tripartite interactions. Understanding the role of arthropod exosomes in pathogen interactions could lead to the discovery of novel therapeutic targets to interfere with the life cycle of several pathogens transmitted by vectors.
Identifiants
pubmed: 32590312
pii: S2214-5745(20)30081-X
doi: 10.1016/j.cois.2020.05.017
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
39-47Subventions
Organisme : NIAID NIH HHS
ID : R01 AI141790
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI130116
Pays : United States
Informations de copyright
Copyright © 2020. Published by Elsevier Inc.