Application of CRISPR/Cas9 to human-induced pluripotent stem cells: from gene editing to drug discovery.
CRISPR/Cas9
Drug discovery
Gene editing
Gene therapy
HIV and SARS-Cov-2 infection
Human-induced pluripotent stem cells (hiPSCs)
Journal
Human genomics
ISSN: 1479-7364
Titre abrégé: Hum Genomics
Pays: England
ID NLM: 101202210
Informations de publication
Date de publication:
26 06 2020
26 06 2020
Historique:
received:
07
05
2020
accepted:
17
06
2020
entrez:
28
6
2020
pubmed:
28
6
2020
medline:
14
7
2020
Statut:
epublish
Résumé
Human-induced pluripotent stem cells (hiPSCs) and CRISPR/Cas9 gene editing system represent two instruments of basic and translational research, which both allow to acquire deep insight about the molecular bases of many diseases but also to develop pharmacological research.This review is focused to draw up the latest technique of gene editing applied on hiPSCs, exploiting some of the genetic manipulation directed to the discovery of innovative therapeutic strategies. There are many expediencies provided by the use of hiPSCs, which can represent a disease model clinically relevant and predictive, with a great potential if associated to CRISPR/Cas9 technology, a gene editing tool powered by ease and precision never seen before.Here, we describe the possible applications of CRISPR/Cas9 to hiPSCs: from drug development to drug screening and from gene therapy to the induction of the immunological response to specific virus infection, such as HIV and SARS-Cov-2.
Identifiants
pubmed: 32591003
doi: 10.1186/s40246-020-00276-2
pii: 10.1186/s40246-020-00276-2
pmc: PMC7318728
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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