[Use and management of proton pump inhibitors: An observational study].
Utilisation et gestion des inhibiteurs de la pompe à protons : une étude observationnelle.
Deprescription
Déprescription
Hospitalisation
Hospitalization
Inappropriate prescriptions
Inhibiteur de la pompe à protons
Prescriptions inappropriées
Proton pump inhibitor
Recommandations
Recommendations
Journal
Therapie
ISSN: 1958-5578
Titre abrégé: Therapie
Pays: France
ID NLM: 0420544
Informations de publication
Date de publication:
Historique:
received:
10
12
2019
revised:
09
03
2020
accepted:
17
03
2020
pubmed:
28
6
2020
medline:
18
9
2021
entrez:
28
6
2020
Statut:
ppublish
Résumé
Proton pump inhibitors (PPIs) have improved the management and prevention of digestive diseases, leading to a heavy prescription of this therapy. In 2015, nearly one quarter of the French population had consumed a PPI and half of them were long-term users. The main objective of this study was to analyze, in patients hospitalized in several medical departments, the adequacy of long-term PPI prescriptions to recommendations. The Use and management of proton pump inhibitors: an observational study project (UTOPPIA) is a longitudinal observational study conducted at the University Hospital of Saint-Étienne in the departments of hepato-gastroenterology, infectious and tropical diseases, internal medicine, vascular medicine and nephrology. All patients with PPI treatment on their usual outpatient prescription were interviewed. Over a 3-month period, 334 of hospitalized patients (30.7%) had received a long-term PPI prescription and 181 patients (54.2%) could be included in the study for a total of 274 indications. Ninety-nine patients (54.7%) had a long-term PPI prescription in accordance with the recommendations. The most frequent indication (70 prescriptions) was the prescription of an antiplatelet drug or anticoagulant for subjects at high risk of bleeding in 70 prescriptions. Fifty-three PPI treatments were amended during the hospital stay, including 9 discontinuations. The justification for the change was documented in the patients' chart in only 17% of cases. Individual interviews of patients revealed that 75.1% of them were in favour of discontinuing their PPI treatment. About one-third of hospitalized patients in medical wards in France have long-term PPI treatment and half of these prescriptions do not comply with good practice recommendations. A majority of patients report being willing to try to stop PPI therapy.
Identifiants
pubmed: 32591130
pii: S0040-5957(20)30103-7
doi: 10.1016/j.therap.2020.03.002
pii:
doi:
Substances chimiques
Proton Pump Inhibitors
0
Types de publication
Journal Article
Observational Study
Langues
fre
Sous-ensembles de citation
IM
Pagination
649-662Informations de copyright
Copyright © 2020 Société française de pharmacologie et de thérapeutique. Published by Elsevier Masson SAS. All rights reserved.