Interferon, restriction factors and SUMO pathways.

Antiviral Agents Humans Interferons Promyelocytic Leukemia Protein / metabolism SUMO-1 Protein Sumoylation
IFN ISG15 PML SUMO TRIM25 Ubiquitin

Journal

Cytokine & growth factor reviews
ISSN: 1879-0305
Titre abrégé: Cytokine Growth Factor Rev
Pays: England
ID NLM: 9612306

Informations de publication

Date de publication:
10 2020
Historique:
received: 13 02 2020
accepted: 18 03 2020
pubmed: 28 6 2020
medline: 23 9 2021
entrez: 28 6 2020
Statut: ppublish

Résumé

SUMOylation is a reversible post-translational modification that regulates several cellular processes including protein stability, subcellular localization, protein-protein interactions and plays a key role in the interferon (IFN) pathway and antiviral defense. In human, three ubiquitously expressed SUMO paralogs (SUMO1, 2 and 3) have been described for their implication in both intrinsic and innate immunity. Differential effects between SUMO paralogs are emerging such as their distinctive regulations of IFN synthesis, of IFN signaling and of the expression and function of IFN-stimulated gene (ISG) products. Several restriction factors are conjugated to SUMO and their modifications are further enhanced in response to IFN. Also, IFN itself was shown to increase global cellular SUMOylation and requires the presence of the E3 SUMO ligase PML that coordinates the assembly of PML nuclear bodies. This review focuses on differential effects of SUMO paralogs on IFN signaling and the stabilization/destabilization of ISG products, highlighting the crosstalk between SUMOylation and other post-translational modifications such as ubiquitination and ISGylation.

Identifiants

DOI: 10.1016/j.cytogfr.2020.03.001 PMID: 32591223
pubmed: 32591223
pii: S1359-6101(20)30025-3
doi: 10.1016/j.cytogfr.2020.03.001
pii:
doi:

Substances chimiques

Antiviral Agents 0
Promyelocytic Leukemia Protein 0
SUMO-1 Protein 0
Interferons 9008-11-1

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

37-47

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

Auteurs

Faten El-Asmi (F)

INSERM UMR-S 1124, Université Paris Descartes, 45 rue des Saints Pères, 75006, Paris, France.

Francis P McManus (FP)

Institute for Research in Immunology and Cancer, Quebec, Canada.

Pierre Thibault (P)

Institute for Research in Immunology and Cancer, Quebec, Canada; University of Montreal, Department of Chemistry, Quebec, Canada.

Mounira K Chelbi-Alix (MK)

INSERM UMR-S 1124, Université Paris Descartes, 45 rue des Saints Pères, 75006, Paris, France. Electronic address: mounira.chelbi-alix@parisdescartes.fr.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Interferon, restriction factors and SUMO pathways.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Interferon, restriction factors and SUMO pathways.
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interférons › Interferon, restriction factors and SUMO pathways.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines à motif tripartite › Protéine de la leucémie promyélocytaire › Interferon, restriction factors and SUMO pathways.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Ubiquitines › Petites protéines modificatrices apparentées à l'ubiquitine › Protéine SUMO-1 › Interferon, restriction factors and SUMO pathways.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › Ubiquitination › Sumoylation › Interferon, restriction factors and SUMO pathways.