Rb and p53 Execute Distinct Roles in the Development of Pancreatic Neuroendocrine Tumors.

Animals Cell Transformation, Neoplastic / genetics Mice Mice, Transgenic Neuroendocrine Tumors / genetics Pancreatic Neoplasms / genetics Retinoblastoma Protein / genetics Tumor Suppressor Protein p53 / genetics

Journal

Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R

Informations de publication

Date de publication:
01 09 2020
Historique:
received: 20 08 2019
revised: 26 02 2020
accepted: 23 06 2020
pubmed: 28 6 2020
medline: 12 1 2021
entrez: 28 6 2020
Statut: ppublish

Résumé

Pancreatic neuroendocrine tumors (PanNET) were classified into grades (G) 1 to 3 by the World Health Organization in 2017, but the precise mechanisms of PanNET initiation and progression have remained unclear. In this study, we used a genetically engineered mouse model to investigate the mechanisms of PanNET formation. Although pancreas-specific deletion of the

Identifiants

DOI: 10.1158/0008-5472.CAN-19-2232 PMID: 32591410
pubmed: 32591410
pii: 0008-5472.CAN-19-2232
doi: 10.1158/0008-5472.CAN-19-2232
doi:

Substances chimiques

Retinoblastoma Protein 0
Tumor Suppressor Protein p53 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3620-3630

Informations de copyright

©2020 American Association for Cancer Research.

Auteurs

Yuki Yamauchi (Y)

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, Kyoto, Japan.

Yuzo Kodama (Y)

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, Kyoto, Japan. kodama@med.kobe-u.ac.jp.
Department of Gastroenterology, Kobe University Graduate School of Medicine, Chuo-ku, Kobe, Hyogo, Japan.
ORCID: 0000-0003-1223-7147

Masahiro Shiokawa (M)

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, Kyoto, Japan.

Nobuyuki Kakiuchi (N)

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, Kyoto, Japan.
ORCID: 0000-0003-4893-5414

Saiko Marui (S)

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, Kyoto, Japan.

Takeshi Kuwada (T)

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, Kyoto, Japan.
ORCID: 0000-0002-9808-4139

Yuko Sogabe (Y)

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, Kyoto, Japan.

Teruko Tomono (T)

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, Kyoto, Japan.

Atsushi Mima (A)

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, Kyoto, Japan.

Toshihiro Morita (T)

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, Kyoto, Japan.
ORCID: 0000-0002-4114-9894

Tomoaki Matsumori (T)

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, Kyoto, Japan.

Tatsuki Ueda (T)

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, Kyoto, Japan.
ORCID: 0000-0002-6705-5626

Motoyuki Tsuda (M)

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, Kyoto, Japan.

Yoshihiro Nishikawa (Y)

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, Kyoto, Japan.
ORCID: 0000-0002-1113-6937

Katsutoshi Kuriyama (K)

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, Kyoto, Japan.
ORCID: 0000-0002-3985-9774

Yojiro Sakuma (Y)

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, Kyoto, Japan.

Yuji Ota (Y)

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, Kyoto, Japan.

Takahisa Maruno (T)

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, Kyoto, Japan.

Norimitsu Uza (N)

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, Kyoto, Japan.
ORCID: 0000-0002-1334-5740

Atsuhiro Masuda (A)

Department of Gastroenterology, Kobe University Graduate School of Medicine, Chuo-ku, Kobe, Hyogo, Japan.

Hisato Tatsuoka (H)

Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, Kyoto, Japan.
ORCID: 0000-0002-0669-6825

Daisuke Yabe (D)

Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, Kyoto, Japan.
ORCID: 0000-0002-5334-7687

Sachiko Minamiguchi (S)

Department of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, Kyoto, Japan.
ORCID: 0000-0002-5800-6769

Toshihiko Masui (T)

Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Kyoto University, Shogoin-Kawahara, Sakyo-ku, Kyoto, Japan.

Nobuya Inagaki (N)

Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, Kyoto, Japan.

Shinji Uemoto (S)

Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Kyoto University, Shogoin-Kawahara, Sakyo-ku, Kyoto, Japan.

Tsutomu Chiba (T)

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, Kyoto, Japan.
Kansai Electric Power Hospital, Fukushima-ku, Osaka, Japan.

Hiroshi Seno (H)

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, Kyoto, Japan.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Rb and p53 Execute Distinct Roles in the...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Carcinogenèse › Transformation cellulaire néoplasique › Rb and p53 Execute Distinct Roles in the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Rb and p53 Execute Distinct Roles in the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Rb and p53 Execute Distinct Roles in the...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroendocrines › Rb and p53 Execute Distinct Roles in the...
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Rb and p53 Execute Distinct Roles in the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › Protéine du rétinoblastome › Rb and p53 Execute Distinct Roles in the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › Protéine p53 suppresseur de tumeur › Rb and p53 Execute Distinct Roles in the...